Rochemartensen1970

Vascular calcifications (VCs), recognized risk factor for increased mortality, are highly prevalent in hemodialysis (HD) patients. We aimed to investigate the relation between VC and warfarin use with plain radiography.

VCs were assessed using Adragao (radial and digital) and Kauppila (aortic) scores in 76 HD patients from six centers. Out of a total 711 HD patients there were 32 (4.5%) who had been treated with warfarin for at least 1 year and we included 44 control patients.

Of the patients, 47% were females, the mean age was 66 ± 9 years, 23% were diabetics, the mean dialysis vintage was 68 ± 38 months. In warfarin group, median Kauppila score was higher than in control group [11 vs 6.5, (25%-75% percentile, 5 vs. 15), P=0.032] and the percentage of the patients with a Kauppila score of >6 was higher, as well (76.6% vs. 50%; P=0.029). Median Adragao score was not significantly different between the two groups [7 vs. 6, (%25,%75 percentile 6 vs. 8), P=0.17]. Logistic regression analysis revealed that warfarin treatment was independently associated with Kauppila scores of >6 (OR 3.60, 95% CI 1.18-10.9, P=0.024).

In this study, we found that warfarin is associated to vascular calcifications, especially in aorta of HD patients.

In this study, we found that warfarin is associated to vascular calcifications, especially in aorta of HD patients.Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been appeared first in China since December 2019. Transmission of SARS-CoV-2 occurs primarily with droplets through coughing and sneezing, is also occurs through inhalation of aerosolized secretions, which travel, remain suspended in the air longer. Since early in the outbreak, have described COVID-19 cases in healthcare workers (HCWs). In the early stages of the disease, there may be asymptomatic. This may lead to incorrect diagnosis or delayed diagnosis and may lead to the nosocomial spread of the virus. One of the most important causes of transmission among HCWs is an aerosolized virus in a closed environment for a long time. It is possible to prevent and control the spread of COVID-19 in hospitals with outpatient treatment and triage. Infection control measures, including wearing surgical masks, hand hygiene, and social distance, are considered essential in preventing human-to-human transmissions of SARS-CoV-2. Immediate response and practices of infection control measures are critical for saving lives during an epidemic inside and outside the hospital. Analyzing current knowledge about the features of SARS-CoV-2 infection, screening, personal protection protocols, triage and psychological support practices for healthcare professionals can be promising in terms of controlling the infection.

The management of nodules with indeterminate cytology (atypia of undetermined significance (AUS), follicular lesion of undetermined significance (FLUS), follicular neoplasm (FN), suspicious for a follicular neoplasm (SFN) and suspicious for malignancy (SM)) results is controversial.

To assess the role of elastography technique in the diagnosis of malignancy in the subtypes of indeterminate thyroid nodules.

We included 132 patients with indeterminate cytology who underwent thyroid surgery. Sensitivity, specificity, area under the curve and optimal cut-off points were calculated with receiver operating characteristic (ROC) analysis for elastography score (ES) and strain index (SI).

Malignancy was observed in 27/95 (28.4%) of the AUS-FLUS cytology and 12/24 (50%) of FN, SFN cytology. All of the 13 patients (100 %) with SM are found to be malignant on histology. In FLUS group, nodules with ES greater or equal to 3, the presence of malignancy was higher 17/41 (41.5%) when compared with nodules with ES smaller than 3 9/46 (19.6 %) (p=0.023). In SFN group 2 of 2 nodules with ES score of 4 and 1 of 1 nodules with ES score of 5 were malignant. In FLUS group 4 of 10 nodules with ES score of 4 and 2 of 2 nodules with ES score of 5 were malignant.

Thyroid elastography may reduce unnecessary surgery for both patients with AUS and selected SFN cytology. Elastography appears to be helpful in follicular variants and other types of papillary thyroid cancer however, not in follicular thyroid cancer.

Thyroid elastography may reduce unnecessary surgery for both patients with AUS and selected SFN cytology. Elastography appears to be helpful in follicular variants and other types of papillary thyroid cancer however, not in follicular thyroid cancer.

Colorectal anastomotic leakage (AL) is a life-threatening complication, which increases morbidity, hospital stay and cost of treatment. The aim of this study is to identify risk factors, including intraoperative indocyanine green fluorescence angiography (ICG FA), associated with the leak of stapled colorectal anastomosis.

Four hundred twenty-nine consecutive patients underwent surgery between 2017 and 2019 for benign (n=10, 2.3%) or malignant (n=419, 97.7%) and rectal (n=349, 81.4%) or distal sigmoid (n=80, 18.6%) lesions with double-stapling technique reconstruction were included into retrospective study. Univariate analysis and multivariate logistic regression of the tumor-, patient- and treatment-related risk factors of AL was performed.

An AL developed in 52 patients (12.1%). In multivariate analysis following variables were independently associated with AL; male sex (odds ratio [OR], 3.8; 95% confidence interval [CI], 1.9-7.7; P<0.01), anastomosis at ≤6.5 cm from anal verge (OR, 3.1; 95% CI, 1.3-7.5; P=0.01), and age of ≤62.5 years (OR, 2.1; 95% CI, 1.1-4.1; P=0.03). ICG FA was found as independent factor reducing colorectal AL rate (OR, 0.4; 95% CI, 0.2-0.8; P=0.02). A nomogram with high discriminative ability (concordance index, 0.81) was created.

ICG FA is a modifiable surgery-related risk factor associated with a decrease of colorectal AL rate. A suggested nomogram, which takes into consideration ICG FA, might be helpful to identify the individual risk of AL.

ICG FA is a modifiable surgery-related risk factor associated with a decrease of colorectal AL rate. A suggested nomogram, which takes into consideration ICG FA, might be helpful to identify the individual risk of AL.

A meta-analysis was conducted to determine the proportion of contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System category M (LR-M) in hepatocellular carcinomas (HCCs) and non-HCC malignancies and to investigate the frequency of individual CEUS LR-M imaging features.

The MEDLINE and Embase databases were searched from inception to July 23, 2020 for studies reporting the proportion of CEUS LR-M in HCC and non-HCC malignancies. The meta-analytic pooled proportions of HCC and non-HCC malignancies in the CEUS LR-M category were calculated. The meta-analytic frequencies of CEUS LR-M imaging features in non-HCC malignancies were also determined. Risk of bias and applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.

Twelve studies reporting the diagnostic performance of the CEUS LR-M category were identified, as well as seven studies reporting the frequencies of individual CEUS LR-M imaging features. The pooled proportions of HCC and non-HCC malignancies in the CEUS LR-M category were 54% (95% confidence interval [CI], 44% to 65%) and 40% (95% CI, 28% to 53%), respectively. The pooled frequencies of individual CEUS LR-M imaging features in non-HCC malignancies were 30% (95% CI, 17% to 45%) for rim arterial phase hyperenhancement, 79% (95% CI, 66% to 90%) for early (<60 s) washout, and 42% (95% CI, 21% to 64%) for marked washout.

In total, 94% of CEUS LR-M lesions were malignancies, with HCCs representing 54% and non-HCC malignancies representing 40%. The frequencies of individual CEUS LR-M imaging features varied; early washout showed the highest frequency for non-HCC malignancies.

In total, 94% of CEUS LR-M lesions were malignancies, with HCCs representing 54% and non-HCC malignancies representing 40%. The frequencies of individual CEUS LR-M imaging features varied; early washout showed the highest frequency for non-HCC malignancies.

This study assessed the efficacy and safety of adalimumab (ADA) and explored predictors of response in Korean patients with ulcerative colitis (UC).

A prospective, observational, multicenter study was conducted over 56 weeks in adult patients with moderately to severely active UC who received ADA. Clinical response, remission, and mucosal healing were assessed using the Mayo score.

A total of 146 patients were enrolled from 17 academic hospitals. Clinical response rates were 52.1% and 37.7% and clinical remission rates were 24.0% and 22.0% at weeks 8 and 56, respectively. Mucosal healing rates were 39.0% and 30.1% at weeks 8 and 56, respectively. Prior use of anti-tumor necrosis factor-α (anti-TNF-α) did not affect clinical and endoscopic responses. The ADA drug level was significantly higher in patients with better outcomes at week 8 (P<0.05). In patients with lower endoscopic activity, higher body mass index, and higher serum albumin levels at baseline, the clinical response rate was higher at week 8. In patients with lower Mayo scores and C-reactive protein levels, clinical responses, and mucosal healing at week 8, the clinical response rate was higher at week 56. Danuglipron ic50 Serious adverse drug reactions were identified in 2.8% of patients.

ADA is effective and safe for induction and maintenance in Korean patients with UC, regardless of prior anti-TNF-α therapy. The ADA drug level is associated with the efficacy of induction therapy. link2 Patients with better short-term outcomes were predictive of those with an improved long-term response.

ADA is effective and safe for induction and maintenance in Korean patients with UC, regardless of prior anti-TNF-α therapy. The ADA drug level is associated with the efficacy of induction therapy. Patients with better short-term outcomes were predictive of those with an improved long-term response.This paper describes the fabrication, modification, and evaluation of the performance of thin-film composite (TFC) forward osmosis (FO) membranes for lab-scale aquaculture wastewater recovery using various fumed silica (SiO2) nanoparticles. The active polyamide (PA) layers of these membranes were novelly modified using different types of pretreated SiO2 nanoparticles [virgin SiO2, dried SiO2, and 3-aminopropyltriethoxysilane (APTES)-modified SiO2] and concentrations (0.05, 0,1, 0,2, and 0.4 wt%) to improve the membrane hydrophilicity with minimum particle agglomeration. Results show that the APTES-SiO2 modified membrane had the highest water flux and selectivity, followed by the dried-SiO2 modified membrane. The APTES coupling agent notably reduced the SiO2 aggregation on the membrane surface and improved membrane hydrophilicity. Consequently, high permeate flux and an acceptable reverse solute flux were observed. link3 The optimal SiO2 concentration for PA modification was 0.1 wt% for all the nanoparticle types. The virgin and APTES-SiO2 modified membranes were used for aquaculture wastewater recovery. The water recovery rate reached 47% in 84 h when using the APTES-SiO2 modified membrane, while it reached only 26% in 108 h when using the virgin membrane. With a suitable design of the filtration apparatus and choice of draw solution (DS), the prepared novel TFC-FO membrane containing APTES-modified SiO2 can be used for recycling aquaculture wastewater into the DS, which can then be reused for other purposes.