Bowlingottesen4604

tuberculosis cells in the sputum of 21% of subjects with DS TB, and this proportion rose to 65% after 2 weeks of treatment with first-line drugs. In subjects with DR TB, DD-Mtb cells were found in the sputum of 29% of subjects prior to treatment initiation, and this proportion remained steady at 31% after 2 weeks of treatment with second-line drugs. By 2 months, DD-Mtb cells were detected in the sputum of only 2/15 (13.3%) subjects with DS TB and in 0/15 of subjects with DR TB. One of the DS subjects whose sputum was positive for DD-Mtb at month 2 later experienced treatment failure.Aztreonam-avibactam is a drug combination pending phase 3 clinical trials and is suggested for treatment of severe infections caused by metallo-beta-lactamase (MBL)-producing Enterobacterales by combining ceftazidime-avibactam and aztreonam. Beginning in 2019, four Antibiotic Resistance Laboratory Network regional laboratories offered aztreonam-avibactam susceptibility testing by broth microdilution. For 64 clinical isolates tested, the MIC50 and MIC90 values of aztreonam-avibactam were 0.5/4 μg/ml and 8/4 μg/ml, respectively. Aztreonam-avibactam displayed potent in vitro activity against the MBL-producing Enterobacterales tested.Previous research mostly focused on early parenting stress or postpartum symptoms of mental illness whereas the topic of a successful transition to motherhood and its long-term effects on parenting and child well-being remained more or less neglected. The present longitudinal study investigated whether a successful transition to motherhood influences emotionally warm parenting behavior, children's emotion regulation, and subjective life satisfaction. A successful transition to motherhood is feeling satisfied, self-efficient, and energetic in the maternal role during the first year after birth. Survey data from a large, nationally representative panel study with four measurement points across 11 years were analyzed using structural equation modeling (SEM). T1 corresponds to child's first year of life, at T2 children were around 3, at T3 the children were around 8, and at T4 children were around 12 years old. SIS3 in vivo The study sample comprised 322 mother-child dyads. Mothers completed questionnaires to assess their early transition to motherhood (T1), children's emotion regulation (T1 and T2), and maternal warmth (T3). At age 12 (T4), children self-reported their life satisfaction. Results confirmed that a successful transition to motherhood had positive, long-term effects on maternal warmth and children's emotion regulation. Moreover, adapting optimally to motherhood had an indirect positive effect on children's subjective life satisfaction at age 12. Life satisfaction was in turn positively affected by maternal warmth and children's emotion regulation. The results highlight the importance of a successful transition to motherhood for parenting, children's emotion regulation, and life satisfaction. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Multiracial children are the largest demographic group in the United States among individuals under the age of 18 (Pew Research Center, 2015), but their developmental processes are understudied. Parents and caregivers play an important role in preparing youth to navigate racialized society by teaching them to understand what it means to be a member of a racial-ethnic group (Hughes et al., 2006). However, this process is more complex in multiracial families, where youth belong to multiple racial-ethnic groups. Thus, the purpose of the present study was to develop and validate the first measure of racial-ethnic socialization for Multiracial youth, the Multiracial Youth Socialization (MY-Soc) Scale, to assess the unique messages that are communicated in multiracial families regarding topics of race, ethnicity, and culture. Using a sample of 901 Multiracial emerging adults (mage = 22.43), we separately captured the socialization practices of two of the youths' primary caregivers from the youths' perspective. Exploratory and confirmatory factor analyses supported a 62-item scale measuring eight types of socialization Navigating Multiple Heritages Socialization, Multiracial Identity Socialization, Preparation for Monoracism Socialization, Negative Socialization, Colorblind Socialization, Diversity Appreciation Socialization, Race-Conscious Socialization, and Silent Socialization. The MY-Soc Scale was also supported by validity and reliability tests. This study contributes an important tool for scholars and practitioners to learn which racial-ethnic socialization messages are promotive for Multiracial youth development in different contexts. (PsycInfo Database Record (c) 2021 APA, all rights reserved).A large body of literature suggests that parent-child separation predicts child maladjustment. However, further advancement in methodology is needed to account for heterogeneity in types of separation. Additionally, given a lack of research examining different types of separation as predictors of offspring substance use, further research into this topic is warranted. The present study tested the relation between parent-child separation and young-adult substance use disorder (SUD), capturing heterogeneity in these effects based on group differences and measurement of separation. In a sample of 427 young adults from a larger longitudinal study oversampled for parental alcohol use disorder (AUD), effects of number and type of separations on SUD diagnosis were tested. Further, we explored whether these associations were moderated by gender, ethnicity, or parental AUD. Two underlying types of separation were found parental health-related separation (i.e., parental death, hospitalization) and nonhealth-related separation (i.e., divorce, arrest). A higher sum of separations and greater nonhealth-related separation predicted higher odds of SUD. Greater health-related separation predicted lower odds of SUD. However, these effects were qualified by interactions with ethnicity and parental AUD. Although the vast majority of studies measure cumulative parent-child separation with sum scores, the present study demonstrates that measuring underlying "types" of cumulative separation also reveals important effects. Moreover, childhood separation is a significant risk factor for SUD. Future research on separation should implement methods to capture separation types and further account for potential effects of selection into separation types. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Joint physical custody (JPC), a parental care arrangement in which children live with each parent about equally after separation or divorce, is an increasingly common phenomenon in many countries. This is a major shift away from the standard of sole physical custody (SPC), in which children live primarily with one parent (usually their mother) after family dissolution. Although attention to JPC by social scientists is growing, and the effects of this arrangement on children's well-being are the subject of highly ideological debates, there is currently little empirical evidence with statistical power on JPC. Using data from Family Models in Germany (FAMOD), a survey of postseparation families conducted in 2019, we estimated four linear regression models for children aged 2-14 in SPC and JPC families, with analytic samples of up to 1,161 cases. We investigated the association between physical custody arrangements after separation or divorce and four dimensions of children's well-being psychological, physical, social, and cognitive/educational. The bivariate results provided support for the hypothesis that children living in JPC families fare significantly better than children living in SPC families on all four dimensions of well-being. However, after controlling for a set of child, parent, and separation characteristics, as well as for the quality of family relationships, the differences between children from SPC and JPC families disappeared. Additional analyses revealed that the parent-child relationships fully mediated this association. In sum, the quality of family relationships accounted for the positive association between JPC and children's well-being in this study. link2 (PsycInfo Database Record (c) 2021 APA, all rights reserved).Objective The Internalized Stigma of Mental Illness (ISMI) scale is widely used to examine internalized stigma among people with mental illness. link3 However, an Indonesian version does not yet exist. We developed an Indonesian translation of the ISMI scale and assessed its psychometric properties. Method We included 280 inpatients with mental illness diagnoses in 2 hospitals and a rehabilitation center. We followed the guidelines proposed by Sousa and Rojjanasrirat (2011) to translate the questionnaire. The reliability was evaluated by measuring the internal consistency (Cronbach's alpha) and test-retest reliability. Test validity was measured through exploratory factor analysis (EFA) to examine the structure of the scale and confirmatory factor analysis (CFA) to determine the model fits. Results The EFA yielded 5 factors with Cronbach's alpha coefficients of .96 for the total scale and .95, .95, .93, .94, and .82 for the 5 subscales. The test-retest reliability indicated excellent results, demonstrated by the interclass correlation coefficient ranging between .76 and .92 for all ISMI scale items. The Kaiser-Meyer-Olkin test statistic was 0.95, and Bartlett's test of sphericity value was significant. Conclusions and Implications for Practice The CFA indicated that the ISMI scale has an acceptable model fit. The Indonesian version of the ISMI scale demonstrated good psychometric properties for measuring internalized stigma of psychiatric patients in Indonesia. (PsycInfo Database Record (c) 2021 APA, all rights reserved).We present an agent-based model for studying the societal implications of attitude change theories. Various psychological theories of persuasive communication at the individual level are implemented as simulation experiments. The model allows us to investigate the effects of contagion and assimilation, motivated cognition, polarity, source credibility, and idiosyncratic attitude formation. Simulations show that different theories produce different characteristic macrolevel patterns. Contagion and assimilation are central mechanisms for generating consensus, however, contagion generates a radicalized consensus. Motivated cognition causes societal polarization or the fragmentation of attitudes. Polarity and source credibility have comparatively little effect on the societal distribution of attitudes. We discuss how the simulations provide a bridge between microlevel psychological theories and the aggregated macrolevel studied by sociology. This approach enables new types of evidence for evaluating psychological theory to complement experimental approaches, thus answering calls to enhance the role of coherent and formalized theory in psychological science. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Community participation is important to the well-being of people with serious mental illnesses. While theories suggest that depressive symptoms can negatively impact community participation, evidence from previous studies was inconclusive. This study analyzed the relationship between severity of depressive symptoms and various participation constructs including number of days of participation in various community activities, breadth of interests in participating in community activities, and satisfaction with the amount to which one participates. A national sample of individuals with serious mental illnesses (n = 296) was employed. Overall, those who were severely depressed had fewer total days of participation, reported fewer participation areas as important, were less likely to participate in those areas that were important to them, and were less likely to participate as much as they wanted to in areas that were important to them. This relationship generally remained even after controlling for demographics. Overall, the findings from this study suggest that greater attention should be paid to the relationship between depressive symptoms and community participation in this population, including explorations that examine how the promotion of participation may have an impact on depressive symptoms.