Lauhovmand0220

Fusobacterium nucleatum (Fn), a bacterium associated with a wide spectrum of infections, has emerged as a key microbe in colorectal carcinogenesis. However, the underlying mechanisms and clinical relevance of Fn in colorectal cancer (CRC) remain incompletely understood.

We examined associations between Fn abundance and clinicopathologic characteristics among 105 treatment-naïve CRC patients enrolled in the international, prospective ColoCare Study. Electronic medical charts, including pathological reports, were reviewed to document clinicopathologic features. Quantitative real-time polymerase chain reaction (PCR) was used to amplify/detect Fn DNA in preoperative fecal samples. Multinomial logistic regression was used to analyze associations between Fn abundance and patient sex, age, tumor stage, grade, site, microsatellite instability, body mass index (BMI), alcohol consumption, and smoking history. Cox proportional hazards models were used to investigate associations of Fn abundance with overall survivaldiagnostic and prognostic significance in the clinical management of CRC.

Pets are often thought to be detrimental to sleep. Up to 75% of households with children have a pet, and 30-50% of adults and children regularly share their bed with their pets. Despite these high rates, few studies have examined the effect of pet-human co-sleeping on pediatric sleep. This study compared subjective and objective sleep in youth who never, sometimes, or frequently co-slept with pets.

Children (N=188; aged 11-17 years; M=13.25 years) and their parents answered standardized sleep questionnaires assessing timing, duration, onset latency, awakenings, and sleep quality. Children completed a home polysomnography (PSG) sleep study for one night and wore an actigraph for two weeks accompanied with daily sleep diary. Based on reported frequency of bedsharing with pets, children were stratified into three co-sleeping groups never (65.4%), sometimes (16.5%), frequently (18.1%).

Overall, 34.6% of children reported co-sleeping with their pet sometimes or frequently. Results revealed largely identical sleep profiles across co-sleeping groups; findings were congruent across sleep measurement (subjective child, parent report; objective PSG, actigraphy). Effect sizes indicated that frequent co-sleepers had the highest overall subjective sleep quality, but longest PSG onset-latency compared to the sometimes group.

Co-sleeping with pets was prevalent in one third of children. Sleep dimensions were similar regardless of how frequently children reported sharing their bed with their pet. Future research should examine dyadic measurement of co-sleepers to derive causal evidence to better inform sleep recommendations.

Co-sleeping with pets was prevalent in one third of children. Sleep dimensions were similar regardless of how frequently children reported sharing their bed with their pet. Future research should examine dyadic measurement of co-sleepers to derive causal evidence to better inform sleep recommendations.

Dispositional characteristics like emotional stability and social cynicism have been consistently associated with negative affect, which is a known predictor and outcome of poor sleep quality. This study hypothesized a bidirectional relationship of sleep quality with emotional stability and social cynicism over a five-year period.

Participants were 7,181 Chinese people, who completed two waves of online surveys from a larger panel study. Questionnaires on Big Five personality traits, social cynicism, and sleep quality were administered twice at a five-year interval.

Cross-lagged analysis revealed a significant bidirectional relationship between emotional stability and sleep quality over five years as hypothesized. However, there was no association between sleep quality and social cynicism in either direction.

Our study provides consistent evidence of a bidirectional relationship between sleep quality and emotional stability in a five-year time-frame among a younger population (mean age=24.86). Given the critical role of emotional stability in various areas of functioning, the findings highlight the importance of sleep health education in young adults, who are going through a critical period of personality development.

Our study provides consistent evidence of a bidirectional relationship between sleep quality and emotional stability in a five-year time-frame among a younger population (mean age = 24.86). https://www.selleckchem.com/products/ipi-549.html Given the critical role of emotional stability in various areas of functioning, the findings highlight the importance of sleep health education in young adults, who are going through a critical period of personality development.

To determine whether continuous eye blink measures could identify drowsiness in patients with obstructive sleep apnea (OSA) during a week of naturalistic driving.

Observational study comparing OSA patients and healthy controls.

Regular naturalistic driving across one week.

Fifteen untreated moderate to severe OSA patients and 15 age (± 5 years) and sex (female=6) matched healthy controls.

Participants wore an eye blink drowsiness recording device during their regular driving for one week.

During regular driving, the duration of time with no ocular movements (quiescence), was elevated in the OSA group by 43% relative to the control group (mean [95% CI] 0.20[0.17, 0.25] vs 0.14[0.12, 0.18] secs, P=.011). During long drives only, the Johns Drowsiness Scale was also elevated and increased by 62% in the OSA group relative to the control group (1.05 [0.76, 1.33] vs 0.65 [0.36, 0.93], P=.0495). Across all drives, critical drowsiness events (defined by a Johns Drowsiness Scale score ≥2.6) were twice as frequent in the OSA group than the control group (rate ratio [95% CI] =1.93 [1.65, 2.25], P ≤ .001).

OSA patients were drowsier than healthy controls according to some of the continuous real time eye blink drowsiness measures. The findings of this pilot study suggest that there is potential for eye blink measures to be utilized to assess fitness to drive in OSA patients. Future work should assess larger samples, as well as the relationship of eye blink measures to conventional fitness to drive assessments and crash risk.

OSA patients were drowsier than healthy controls according to some of the continuous real time eye blink drowsiness measures. The findings of this pilot study suggest that there is potential for eye blink measures to be utilized to assess fitness to drive in OSA patients. Future work should assess larger samples, as well as the relationship of eye blink measures to conventional fitness to drive assessments and crash risk.