Ditlevsenfiltenborg9579

Intracellular lipid deposition has been reported in thyroid glands in obese animal and human. To understand the regulatory mechanism of lipid metabolism in thyroid cancer, we investigated the expression status of liver X receptor (LXR) and analyzed its clinicopathological characteristics and molecular biological features.

Expression status of LXR and its transcriptional targets in human cancers were analyzed using The Cancer Genome Atlas (TCGA). The gene-sets related to high LXRβ expression was investigated by gene set enrichment analysis (GSEA) using Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways and gene ontology biologic process. PD-1/PD-L1-IN 7 Quantitative reverse transcription polymerase chain reaction was performed in thyroid cancer samples using our validation cohort.

In contrast to low expression of LXRα, LXRβ was highly expressed in thyroid cancer compared to the other types of human cancers. High LXRβ expression was correlated with the expression of LXRβ transcriptional targets genes, such as apolipoprotein C1 (APOC1), APOC2, apolipoprotein E (APOE), ATP binding cassette subfamily G member 8 (ABCG8), sterol regulatory elementbinding protein 1c (SREBP1c), and SPOT14. Furthermore, High LXRβ expression group indicated poor clinicopathological characteristics and aggressive molecular biological features independently from the drive mutation status. Mechanistically, high LXRβ expression was coordinately related to ribosome-related gene sets.

The mechanistic link between LXRβ and ribosomal activity will be addressed to develop new diagnostic and therapeutic targets in thyroid cancers.

The mechanistic link between LXRβ and ribosomal activity will be addressed to develop new diagnostic and therapeutic targets in thyroid cancers.Hierarchical plasmonic-photonic microspheres (PPMs) with high controllability in their structures and optical properties have been explored toward surface-enhanced Raman spectroscopy. The PPMs consist of gold nanocrystal (AuNC) arrays (3rd-tier) anchored on a hexagonal nanopattern (2nd-tier) assembled from silica nanoparticles (SiO2NPs) where the uniform microsphere backbone is termed the 1st-tier. The PPMs sustain both photonic stop band (PSB) properties, resulting from periodic SiO2NP arrangements of the 2nd-tier, and a surface plasmon resonance (SPR), resulting from AuNC arrays of the 3rd-tier. Thanks to the synergistic effects of the photonic crystal (PC) structure and the AuNC array, the electromagnetic (EM) field in such a multiscale composite structure can tremendously be enhanced at certain wavelengths. These effects are demonstrated by experimentally evaluating the Raman enhancement of benzenethiol (BT) as a probe molecule and are confirmed via numerical simulations. We achieve a maximum SERS enhancement factor of up to ∼108 when the resonances are tailored to coincide with the excitation wavelength by suitable structural modifications.Multilayer van der Waals (vdWs) semiconductors have promising applications in high-performance optoelectronic devices. However, photoconductive photodetectors based on layered semiconductors often suffer from sizeable dark currents and high external driving bias voltages. Here, we report vertical van der Waals heterostructures (vdWHs) consisting of multilayer indium selenide (InSe) and tellurium (Te). The multilayer InSe-Te vdWH device shows a record high forward rectification ratio greater than 107 at room temperature. The vdWH device achieves an ultrasensitive and broadband photoresponse photodetector with an ultrahigh photo/dark current ratio over 104 and a high detectivity of 1013 Jones under visible light illumination with weak incident power. Moreover, the vdWH device has a photovoltaic effect and can function as a self-powered photodetector (SPPD). The SPPD is also ultrasensitive to a broadband spectrum ranging from 300 to 1000 nm and is capable of detecting weak light signals. This work offers an opportunity to develop next-generation electronic and optoelectronic devices based on multilayer vdWs materials.Potassium-ion batteries (KIBs) have aroused enormous interest for future energy storage technology. However, the current anodes for KIBs greatly suffer from the rapid capacity fading and inferior rate capability. Herein, a free-standing flexible anode, that is, nitrogen-doped carbon nanotube paper (NCTP), which is derived from the pyrolysis of organic polypyrrole materials, is demonstrated for high-performance potassium storage. The correlations between the material structure and electrochemical properties have been investigated by a series of material analysis and characterizations, as well as electrochemical tests. The research results show that the annealing temperature dramatically affects the N-doping content, the carbon defects, and the graphitization degree. Electrochemical tests indicate that the NCTP annealed at 700 °C displays the best performances with a high reversible capacity of 250.1 mA h g-1 at 100 mA g-1 and superior rate capability retaining 133 mA h g-1 at 5 A g-1. The excellent electrochemical properties are derived from a synergic contribution from the moderate N-doping, carbon defect, and high electronic conductivity of the materials. The facile pyrolysis strategy and the appealing performances involved in this work could provide some hints to manipulate high-performance anode materials of KIBs.A well-formed solid electrolyte interface (SEI) is critical for achieving long-term cycling stability in lithium-ion batteries (LIBs). However, the SEI remains the poorly understood component in LIBs especially under dynamic conditions. Here, scanning electrochemical microscopy (SECM) was applied to study the spontaneous reaction on a graphite electrode, SEI formation in the first cycle, SEI evolution during 10 cycles, and the stability of the as-formed SEI in the electrolyte. The conversion, dissolution, stabilization, and growth behaviors of the SEI were determined. Moreover, the SECM results were analyzed in combination with ex situ material characterization to understand the SEI on the graphite electrode comprehensively.