Reeveswaters3616

The aim of the study is to investigate the antihypertensive efficacy, structural and functional remodeling of the heart in patients with resistant hypertension (RH) and rheumatoid arthritis (RA) after 12-month of therapy. The treatment includes angiotensin-converting enzyme inhibitor, calcium channel blocker, diuretics, aldosterone receptor blocker (spironolactone), and immunosuppressive drug (methotrexate). 101 patients with hypertension (H) and RA were examined at the screening visit. 60 patients (mean age 61.9±9.1 years; 84.6% of women) meeting the criteria for RH were selected after 1 month. A randomized, controlled, parallel-group prospective study was conducted. Patients underwent general clinical, laboratory, and Doppler echocardiography investigations. They were divided into 2 groups the main group, which represented patients whom to the basic antihypertensive therapy were added spironolactone 25 mg/day (group 1, n=30), and the comparison group, which represented patients who continued antihypertensivimprovement of LV diastolic function. Patients of group 1 demonstrated a de-escalation of RA activity a dropping of the DAS28-CRP from 5.6 (4.9-6.4) to 4.0 (3.4-5.0) (р less then 0,0001) in the absence of its dynamics in patients of group 2 (from 5.7 (5.0-6.1) to 5.6 (5.0-6.5) (p=0.6)). The addition of spironolactone to basic therapy demonstrates increased antihypertensive efficacy and potent antihypertrophic efficacy. find more These effects are combined with improved systolic and diastolic LV function and a decrease of clinical and laboratory activity of RA in elderly patients with RH in combination with RA.The aim of the study - to determine parameters the left ventricular systolic function among patients with STEMI after different types of treatment strategies. The results of the study are based on the data obtained from a comprehensive examination of 447 patients with IHD STEMI - 280 patients, 91 ones with NSTEMI and the control group consisted of 76 persons with angina pectoris. The study evaluated the risk of death of patients (GRAEME 2.0 scale), levels of MB-CPK and troponin I, LVEF and other echocardiographic parameters for various reperfusion tactics. The results obtained are correlated with the thesis that today PPSI is the most effective method to achieve a full reperfusion of infarct-dependent artery. The study showed greater effectiveness of PPSI in reducing mortality and improving hospital and long-term prognosis in comparison with thrombolytic therapy. The reduction of the relative risk of systolic dysfunction occurs in reperfusion therapy, most strongly when using stenting - RR 0.216, 95% CI 0.110-0.426.The aim of our study was to learn the differences in baseline presentation between NObCAD and obstructive coronary artery disease (ObCAD) subjects, to compare the likelihood of several clinical outcomes and the rate of primary endpoints between this groups. Out study included 165 patients 115 patients with NObCAD ACS, 50 - with ObCAD ACS. Inclusion criteria age >18 year; Presence of any atherosclerotic stenosis greater than 20% but less than 50% in the left main coronary artery, and greater than 20% but less than 70% in any other major epicardial coronary artery. Рatients with NObCAD ACS were randomly assign in an 11 ratio in 2 group Group A (n=55) received dual antiplatelet treatment with aspirin 100-160 mg once daily and clopidogrel 75 mg once daily for three months. Group B (n=60) received only aspirin 100-160 mg once daily for three months. 50 patients with ObCAD ACS entered in group C - controlled group, patients were treated according appropriate treatment guidelines. Clinical, demographic and treatment cardiac events) 1year hospitalization for Myocardial infarction or other cardiovascular causes after index angiography, cardiovascular death, revascularization, survival. We studied type and frequency of bleeding during treatment and follow up period. After data assessment we can tell, that the combination of clopidogrel and aspirin was not significantly more effective than aspirin alone in reducing the rate of myocardial infarction, but there was significant difference between groups regarding the CVD event rates, revascularization frequency and bleeding rate.Aim - to determine oral fluid chemical composition and mineralization level in patients with a wedge-shaped defect and intact hard tissues, conduct correlation between the indicators of cervical enamel and oral fluid. We determined Сa2+, РО43-, SO42 using spectrophotometric method, Na+, К+, Al3+ by atomic emission spectrometry, Mg2+, Zn2+ by atomic absorption spectrometry, Cl- using chloride-selective electrode of pH-meter in oral fluid of 22 patients divided into two groups case - with wedge-shaped defects (2.81+/- 0.73); control - with intact teeth. Correlation of oral fluid and cervical enamel chemical composition of 22 extracted teeth (12 - intact teeth, 10 wedge shape) was made. We used JSM-6490 LV focused beam electron microscope (scanning) with system of energy-dispersive X-ray microanalysis INCA Penta FETх3. Significant differences haven't been found in chemical analyte content and molar ratios (p>0.05) in oral fluid. The level of mineralization potential was 1.64+/-0.11 times higher in patients of thshaped defects in terms of mixed saliva in dynamics.One of the most common complications of complex anticancer therapy is the development of various lesions of the oral cavity, including mucositis, which adversely affects the quality of life of the patient, limits the dose of chemotherapy and radiotherapy, and further adversely affects the effectiveness of complex therapy. Objective - to investigate the dental status of patients who are in anticancer chemotherapy and radiotherapy through clinical examination and calculation hygienic indices. During the study, the oral cavity was examined in 130 patients from 2015-2020, during the examination the dental status was registered and complaints were recorded. The dental status of patients on antitumor chemotherapy and radiotherapy by the method of clinical examination and calculation of hygienic indices (CSR (caries sealed removed), CPI index, Green Vermilion index, Fedorov-Volodkina index) was studied. A clinical examination of the oral cavity of patients who were on anticancer therapy in a cancer hospital revealed that the patients had poor oral hygiene and needed specialized dental treatment.