Daugaardbrun2601
aborative Team Development Illustration offers a structured strategy for advocacy and transformation in other oppressive health systems considering introducing nurse practitioners. This paper provides evidence that physician participants believed partnerships with nurse practitioners could improve patient care delivery. We hope this research will contribute to changing power relations in healthcare and improve outcomes. This may offer hope for integration of family nurse practitioners in countries that currently do not support advanced practice nursing roles.Across two experiments, we examine the relationship between individual differences in working memory (WM) and the acquisition of non-native speech categories in adulthood. While WM is associated with individual differences in a variety of learning tasks, successful acquisition of speech categories is argued to be contingent on WM-independent procedural-learning mechanisms. Thus, the role of WM in speech category learning is unclear. In Experiment 1, we show that individuals with higher WM acquire non-native speech categories faster and to a greater extent than those with lower WM. In Experiment 2, we replicate these results and show that individuals with higher WM use more optimal, procedural-based learning strategies and demonstrate more distinct speech-evoked pupillary responses for correct relative to incorrect trials. We propose that higher WM may allow for greater stimulus-related attention, resulting in more robust representations and optimal learning strategies. We discuss implications for neurobiological models of speech category learning.T cell receptor (TCR) sequencing has emerged as a powerful new technology in analysis of the host-tumour interaction. The advances in NextGen sequencing technologies, coupled with powerful novel bioinformatic tools, allow quantitative and reproducible characterisation of repertoires from tumour and blood samples from an increasing number of patients with a variety of solid cancers. In this review, we consider how global metrics such as T cell clonality and diversity can be extracted from these repertoires and used to give insight into the mechanism of action of immune checkpoint blockade. Furthermore, we explore how the analysis of TCR overlap between repertories can help define spatial and temporal heterogeneity of the anti-tumoural immune response. Finally, we review how analysis of TCR sequence and structure, either of individual TCRs or from sets of related TCRs can be used to annotate the antigenic specificity, with important implications for the development of personalised adoptive cellular immunotherapies.This study seeks to understand the potential safety and health implications of location-based augmented reality gaming apps ("LAR apps") through studying people perception of Pokémon GO, a popular LAR gaming app. These perceptions can affect app usage behavior, app retention rate, and market share which can be critical to policymakers and app developers. An online survey is conducted to capture the impacts of Pokémon GO regarding (i) perceived risk of using the app and opinion of prohibiting its usage while driving and cycling, (ii) frequency of app-related distracted driving and cycling, (iii) frequency of app-induced driving and potentially unsafe driving behavior, (iv) average daily steps before and after using the app, and (v) perceived physical and mental health benefits. Multivariate binary probit models and random parameters ordered probit models were estimated to capture users' and non-users' characteristics that affect these perceptions, attitude, and behavior. The results suggest that LAR gaming apps can potentially promote physical activity by encouraging people to walk more, increase social interactions such as app-related discussions, but also contribute to increased app-related distracted driving and cycling, app-induced driving, and unsafe driving behavior. The study findings and insights can provide valuable feedback to legislators and LAR gaming app developers for designing policies and app mechanisms that can address the safety concerns of using such apps, and provide physical and mental health benefits to its users.It is well established that car driving performance suffers when the driver concurrently engages in a distracting activity, such as talking on a cell phone. The present study investigates whether the effects of driver distraction are short-lived, or rather persist for some time. Age-related differences are evaluated as well. Sixty-three young and 61 older adults were tested in a driving simulator. They were asked to follow a lead car that drove at a constant speed, and to concurrently engage in a pseudorandom sequence of distracting tasks (typing, reasoning, memorizing). When the lead car braked, participants had to brake as well to prevent a collision. The stimulus onset asynchrony between the braking task and the last preceding distraction was 11.49 ± 1.99 s. Each person was tested once in a multitasking condition (as described above), and once in a control condition without distracting tasks. Outcome measures quantified distance keeping and lane keeping while participants braked to the lead car. We found that braking responses differed significantly between conditions; this difference could be interpreted as a combination of performance deficits and compensatory strategies in the multitasking condition compared to the control condition. We also found significant differences between age groups, which could be interpreted similarly. Differences between age groups were less pronounced in the multitasking than in the control condition. All observed effects were associated with participants' executive functioning. Our findings confirm that distractions have an impact on braking responses, and they document for the first time that this impact can persist for about 11.5 s. We attribute this persistence to a task set effect, and discuss the practical relevance of our findings.
To test the hypothesis that intermittent theta burst stimulation (iTBS) variability depends on the ability to engage specific neurons in the primary motor cortex (M1).
In a sham-controlled interventional study on 31 healthy volunteers, we used concomitant transcranial magnetic stimulation (TMS) and electroencephalography (EEG). We compared baseline motor evoked potentials (MEPs), M1 iTBS-evoked EEG oscillations, and resting-state EEG (rsEEG) between subjects who did and did not show MEP facilitation following iTBS. We also investigated whether baseline MEP and iTBS-evoked EEG oscillations could explain inter and intraindividual variability in iTBS aftereffects.
The facilitation group had smaller baseline MEPs than the no-facilitation group and showed more iTBS-evoked EEG oscillation synchronization in the alpha and beta frequency bands. Resting-state EEG power was similar between groups and iTBS had a similar non-significant effect on rsEEG in both groups. Baseline MEP amplitude and beta iTBS-evoked EEG oscillation power explained both inter and intraindividual variability in MEP modulation following iTBS.
The results show that variability in iTBS-associated plasticity depends on baseline corticospinal excitability and on the ability of iTBS to engage M1 beta oscillations.
These observations can be used to optimize iTBS investigational and therapeutic applications.
These observations can be used to optimize iTBS investigational and therapeutic applications.
We demonstrate the advantages and safety of long, intraorbitally-placed needle electrodes, compared to standard-length subdermal electrodes, when recording lateral rectus electromyography (EMG) during intracranial surgeries.
Insulated 25mm and uninsulated 13mm needle electrodes, aimed at the lateral rectus muscle, were placed in parallel during 10 intracranial surgeries, examining spontaneous and stimulation-induced EMG activities. Postoperative complications in these patients were reviewed, alongside additional patients who underwent long electrode placement in the lateral rectus.
In 40 stimulation-induced recordings from 10 patients, the 25mm electrodes recorded 6- to 26-fold greater amplitude EMG waveforms than the 13mm electrodes. The 13mm electrodes detected greater unwanted volume conduction upon facial nerve stimulation, typically exceeding the amplitude of abducens nerve stimulation. Except for one case with lateral canthus ecchymosis, no clinical or radiographic complications occurred in 36 patients (41 lateral rectus muscles) following needle placement.
Intramuscular recordings from long electrode in the lateral rectus offers more reliable EMG monitoring than 13mm needles, with excellent discrimination between abducens and facial nerve stimulations, and without significant complications from needle placement.
Long intramuscular electrode within the orbit for lateral rectus EMG recording is practical and reliable for abducens nerve monitoring.
Long intramuscular electrode within the orbit for lateral rectus EMG recording is practical and reliable for abducens nerve monitoring.
Interpreting lateral spread response (LSR) during microvascular decompression (MVD) for hemifacial spasm (HFS) is difficult when LSRs observed in different muscles do not match. We aimed to analyze LSR patterns recorded in both the orbicularis oris (oris) and mentalis muscles and their relationships with clinical outcomes.
The data of 1288 HFS patients who underwent MVD between 2015 and 2018 were retrospectively reviewed. LSR was recorded in the oris and mentalis muscles through centrifugal stimulation of the temporal branch of the facial nerve after preoperative mapping. The disappearance of LSR following surgery, clinical outcomes, and the characteristics of LSR in oris were analyzed.
After surgery, LSR remained in 100 (7.7%) and 279 (21.6%) of the mentalis and oris muscles, respectively. The postoperative outcome correlated with LSR disappearance in the mentalis, not with that in the oris.
LSR patterns differed in each muscle and may not be correlated with clinical outcomes. LSR in the mentalis and oris muscles should be interpreted differently.
We describe a monitoring protocol characterized by preoperative facial nerve mapping, antidromic stimulation, and recording from multiple muscles. We analyze differences in LSRs in the mentalis and oris muscles and suggest technical points for interpretation.
We describe a monitoring protocol characterized by preoperative facial nerve mapping, antidromic stimulation, and recording from multiple muscles. We analyze differences in LSRs in the mentalis and oris muscles and suggest technical points for interpretation.
The extent of plastic responses of motor cortex (M1) to paired associative stimulation (PAS) varies among healthy subjects. Continuous theta-burst stimulation (cTBS) of cerebellum enhances the mean PAS-induced plasticity in groups of healthy subjects. Rottlerin We tested whether the initial status of Responder or Non -Responder to PAS, influenced the effect of cerebellar stimulation on PAS-induced plasticity.
We assessed in 19 young healthy volunteers (8 Responders, 11 Non-Responders to PAS), how cTBS and iTBS (intermittent TBS) applied to the cerebellum before a PAS protocol influenced the plastic responsiveness of M1 to PAS. We tested whether the PAS-induced plastic effects could be depotentiated by a short cTBS protocol applied to M1 shortly after PAS and whether cerebellar stimulation influenced GABA-ergic intracortical inhibition and M1 plasticity in parallel.
Cerebellar cTBS restored the M1 response to PAS in Non-Responders while cerebellar iTBS turned the potentiating response to PAS to a depressive response in both groups.
