Durhamvad1028

Taken together, these results demonstrate that the hMSC secretome promotes the immunoregulatory and proresolving phenotype of Mregs. Intriguingly, DHA supplementation to hMSCs resulted in a more potentiated immunomodulation with increased CD163 expression and decreased gene expression of matrix metalloproteinase 2 in Mreg-polarized macrophages. These findings highlight the potential of PUFA supplementations as an easy and safe method to improve the hMSC therapeutic potential.Analog hardware used for signal envelope extraction in low-power interfaces for acoustic event detection, owing to its low complexity and power consumption, suffers from low sensitivity and performs poorly under low signal to noise ratios (SNR) found in undersea environments. To overcome those problems, in this paper, we propose a novel passive electromechanical solution for the signal feature extraction in low frequency acoustic range (200-1000 Hz), in the form of a piezoelectric vibration transducer, and a rectifier with a mechanically switched inductor. A simulation study of the novel solution is presented, and a proof-of-concept device is developed and experimentally characterized. We demonstrate its applicability and show the advantages of the passive electromechanical device in comparison to the active electrical solution in terms of operation with lower input signals ( less then 20 mV compared to 40 mV), and higher robustness in low SNR conditions (output voltage loss for -10 dB ≤ SNR less then 40 dB of 1 mV, compared to 10 mV). mTOR inhibitor review In addition to the signal processing performance improvements, compared to our previous work, the utilization of the presented novel passive feature extractor would also decrease power consumption of a detector's channel by over 76%, enabling life-time extension and/or increased quality of detection with larger number of channels. To the best of our knowledge, this is the first solution presented in the literature that demonstrates the possibility of using a passive electromechanical feature extractor in a low-power analog wake-up event detector interface.Environmental pollutants can generate stress in plants causing increased ethylene production that leads to the inhibition of plant growth. Ethylene production by the stressed plant may be lowered by Plant Growth-Promoting Bacteria (PGPB) that metabolizes the immediate precursor of ethylene 1-aminocyclopropane-1-carboxylate (ACC). Thus, engineering PGPB with ACC deaminase activity can be a promising alternative to mitigate the harmful effects of pollutants and thus enhance plant production. Here we show that the aromatics-degrading and metal-resistant Azoarcus sp. CIB behaves as a PGP-bacterium when colonizing rice as an endophyte, showing a 30% increment in plant weight compared to non-inoculated plants. The cloning and expression of an acdS gene led to a recombinant strain, Azoarcus sp. CIB (pSEVA237acdS), possessing significant ACC deaminase activity (6716 nmol mg-1 h-1), constituting the first PGPB of the Rhodocyclaceae family equipped with this PGP trait. The recombinant CIB strain acquired the ability to protect inoculated rice plants from the stress induced by cadmium (Cd) exposure and to increase the Cd concentration in rice seedlings. The observed decrease of the levels of reactive oxygen species levels in rice roots confirms such a protective effect. The broad-host-range pSEVA237acdS plasmid paves the way to engineer PGPB with ACC deaminase activity to improve the growth of plants that might face stress conditions.The development of both light and strong wood-derived materials is an interesting research area, particularly in terms of usability in, e.g., furniture constructions. Honeycomb panels being current industry standard are relatively thick (32 mm and 40 mm), thus their attractiveness in designing furniture is limited. In a few studies, it has been shown that honeycomb panels with paper cores are characterized by unsatisfactory mechanical properties, especially when the composite thickness is less than 20 mm. From the literature, it is also evident that mechanical properties might be improved by introducing auxetic features into the core structure. Even though it is a concept with great potential, there are a few studies dealing with honeycomb panels with auxetic cores made of paper. Furthermore, there is no research on the corner joints made from such material. For this reason, the aim of the study was to test the bending behavior of the corner adhesive joints made of honeycomb panels with double arrow-shaped auxetic cores. Within the research, the core cell was adopted based on literature and preliminary studies, paper auxetic cores were produced by the use of the designed and 3d printed device, and joints stiffness and strength were calculated analytically based on the experiment results. Evaluated corner joints stiffness, both in compression and tension test, is greater for samples made of panels with designed auxetic cores. Surprisingly, in the analyzed range of elasticity, it was statistically proved that the values of joint stiffness coefficient K did not vary significantly between compared joints pairs.

Antimicrobial photodynamic therapy (aPDT) has been proposed as an effective alternative method for the adjunctive treatment of all classes of oral infections. The multifactorial nature of its mechanism of action correlates with various influencing factors, involving parameters concerning both the photosensitizer and the light delivery system. This study aims to critically evaluate the recorded parameters of aPDT applications that use lasers as the light source in randomized clinical trials in dentistry.

PubMed and Cochrane search engines were used to identify human clinical trials of aPDT therapy in dentistry. After applying specific keywords, additional filters, inclusion and exclusion criteria, the initial number of 7744 articles was reduced to 38.

Almost one-half of the articles presented incomplete parameters, whilst the others had different protocols, even with the same photosensitizer and for the same field of application.

No safe recommendation for aPDT protocols can be extrapolated for clinical use.