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Contaminated water (100 ml) in an unstirred batch reactor with an initial bacteriophage concentration of 103 PFU ml-1 could be inactivated by the AgNP-immobilized glass substrate (1 cm × 1 cm, containing 3.7 μg cm-2 silver) suspended centrally in the batch reactor. Complete 3-Log bacteriophage inactivation was achieved within 70 and 80 min for MS2 and T4 bacteriophage, respectively, while the aqueous silver concentration was less than 25 μg l-1. This is significantly lower than the recommended standard for silver in drinking water (i.e. 100 μg l-1, US EPA). Thus, AgNP-immobilized glass may have good potential for generating virus-free drinking water.The results of3He gas pulsed NMR spin-lattice relaxation study in high-porosity (84.9%-97.9%) nematically ordered Al2O3aerogels at 1.5 and 4.2 K are presented. The linear dependence ofT1on gas pressure is observed in aerogels that are pre-plated by helium-4. Nitrogen pre-plating prior to helium-4 pre-plating weakly decreases the3He gas spin-lattice relaxation rate. A few possible mechanisms plausibly involved in3He nuclear magnetic relaxation in aerogels are considered. The suggested nuclear spin-lattice relaxation model due to some magnetically 'dirty' aerogel fibers allows to estimate the effective mean free path of3He atoms in aerogel.We report a hybrid cavity structure based on a suspended microfiber with a diameter of 1.7 μm applied to nanoparticle sensing in water. The proposed hybrid cavity is composed of two symmetrical reflectors with a slotted Au layer in the middle. After being characterized by the finite-difference time-domain method, the obtained strong reflection and sufficiently wide band gap provide the potential to realize an ultrasmall mode volume, which can improve sensitivity and lower loss. In addition, an ultrahigh Q/V ratio of 8.2 × 106 (λ/n)-3 and high resonance transmittance of T = 0.53 can be obtained through optimization analysis. After analyzing the trapping force and resonance shift caused by the change in local electric field, it is proven that our proposed cavity exhibits a high sensitivity and offers a convenient and stable method for particle sensing in water.Hybrid noble metal-semiconductor oxide nanostructures often provide unique and synergetic functionalities that are highly desirable in various practical applications. However, the fabrication of such systems with desired functionalities using cost-effective techniques is still a great challenge. In this work, we report a facile route for the preparation of novel Ag/SnO2 nano-obelisk arrayed thin films on silicon substrates by spray pyrolysis and thermal evaporation techniques. The prepared samples exhibited broadband antireflectance in both UV and visible regions attributed to the refractive index gradient and scattering provided by the nano-obelisk arrays. The localised surface plasmon resonance of silver nanocaps further enhanced the light absorption contributing to the antireflective property of the hybrid system. Ag/SnO2 nano-obelisk arrayed thin film exhibited excellent SERS performance with an enhancement factor of 1.13 × 108 with a limit of detection value of 10-12 M for the trace detection of R6G dye. In addition, Ag/SnO2 nano-obelisk arrayed thin film based SERS substrate exhibited good homogeneity across the measured spots and outstanding stability which are essential for quantitative field analysis. The results indicate that the Ag/SnO2 nano-obelisk arrayed thin films are efficient SERS substrates with the merits of having the ease of production, high sensitivity and stability for various practical sensing applications.Chemotherapy is a mainstay strategy in the management of cancer. Regrettably, current chemotherapeutic agents are cytotoxic not only to cancer cells but also to healthy cells, resulting in dose-limiting serious side effects. Therefore, many researchers are eager to develop new drug delivery systems that may help to decrease the side effects and the target delivery of chemotherapy to cancer cells. One of the epochal drug delivery systems in this field is based on carbon nanotubes technology. learn more The aim of this work is the dual covalent functionalization of single-walled carbon nanotubes (SWCNTs) with doxorubicin (DOX) connected with acid-labile linkage and mannose (Man) as a targeting agent. The characterization of the developed nano-drug by transmission electron microscopy showed good dispersibility of the functionalized SWCNTs with diameters (6-10) nm. Moreover, the percentage of functionalization was determined by thermogravimetric analysis showing 25% of functionalization in the case of SWNCTs-NHN-DOX (7) andimparts this complex a kind of selectivity for cancer cells that overexpress this type of receptors.Obstructive sleep apnoea (OSA) is a chronic disorder that involves a decrease or complete cessation of airflow during sleep. It occurs when the muscles supporting the soft tissues in the throat relax during sleep, causing narrowing or closure of the upper airway. Sleep apnoea is a serious medical condition with an increased risk of cardiovascular complications and impaired quality of life. Continuous positive airway pressure (CPAP) is the most effective treatment for moderate to severe cases of OSA and is effective in mild sleep apnoea. However, CPAP therapy is associated with the development of several nasal side effects and is inconvenient for the user, leading to low compliance rates. The effects of CPAP treatment on the upper respiratory system, as well as the pathogenesis of side effects, are incompletely understood and not adequately researched. To better understand the effects of CPAP treatment on the upper respiratory system, we developed an in vitro 3D-printed microfluidic platform. A nasal epithelial cell line, RPMI 2650, was then exposed to certain conditions to mimic the in-vivo environment. To create these conditions, the microfluidic device was utilized to expose nasal epithelial cells grown and differentiated at the air-liquid interface. The airflow was similar to what is experienced with CPAP, with pressure ranging between 0-20 cm of H20. Cells exposed to pressure showed decreased barrier integrity, change in cellular shape, and increased cell death (lactate dehydrogenase release into media) compared to unstressed cells. Stressed cells also showed increased secretions of inflammatory markers IL-6 and IL-8 and had increased production of ATP. Our results suggest that stress induced by airflow leads to structural, metabolic, and inflammatory changes in the nasal epithelium, which may be responsible for developing nasal side-effects following CPAP treatment.

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