Winklerburke0380

© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.OBJECTIVES Doctor shopping, double doctoring, and overlapping prescriptions are often used as synonyms for multiple physician appointments in the same disease episode. Such behaviours translate into poor patient satisfaction and patient-doctor communication as well as abuse or misuse of drugs, increasing health care costs and resulting in negative health consequences. This systematic review of the literature was conducted to identify factors that drive doctor-shopping behaviour in children's caregivers. METHODS The search was conducted in PubMed and grey literature and was based on the following search terms included doctor or physician shopping, drug seeking, double doctoring, children, and combinations of those. Overall, 500 records were identified, of which 11 were selected for qualitative synthesis. 10058-F4 Data extracted considered definitions of doctor shopping, co-morbidities, and target population characteristics. RESULTS Definitions of doctor shopping were inconsistent. The frequency of doctor shopping was hssary medical resource utilization. © 2020 John Wiley & Sons, Ltd.Breast cancer (BC) has been featured with high incidence and mortality rate in women on the globe. The critical roles of long noncoding RNAs (lncRNAs) in cancer initiation and progression have been deciphered in the past few years. RHPN1 antisense RNA 1 (RHPN1-AS1) has been reported as correlated with uveal melanoma and non-small cell lung cancer, whereas the function of RHPN1-AS1 in BC is still masked. KDM5B has been unveiled as a potential oncogene in BC while the mechanism that KDM5B regulates BC progression via modulating lncRNAs is veiled to a large extent. Herein we discovered overexpression of KDM5B in dendritic cells tissues and cells. Knockdown of KDM5B impeded the viability and migration of BC cells. Moreover, we observed repressed RHPN1-AS1 in the presence of depleted KDM5B and KDM5B exerted its oncogenic role in BC through RHPN1-AS1. RHPN1-AS1 was elevated in BC tissues and cells. Higher RHPN1-AS1 expression was associated with poorer prognosis of patients with BC. Silence of RHPN1-AS1 repressed BC cell growth and migration. Mechanically, we found RHPN1-AS1 acted as a molecular sponge of miR-6884-5p and thus deregulate Annexin A11 (ANXA11), a target gene of miR-6884-5p. Rescue assay further validated that RHPN1-AS1 contributed to BC progression by regulating the miR-6884-5p/ANXA11 axis. Taken together, this study revealed that RHPN1-AS1 was induced by KDM5B and promoted BC via the RHPN1-AS1/miR-6884-5p/ANXA11 pathway. These results and findings could shed novel light on BC tumorigenesis. © 2020 Wiley Periodicals, Inc.Herein, we report an approach to combat counterfeiting and storage of valuable information based on the solid-state fluorescence switching behavior of isoniazid functionalized naphthalene diimide (ISO_NDI) in response to an external stimuli (i. e., HCl vapor). The unique feature of ISO_NDI is further utilized to develop an invisible ink (ISO_NDI-PVA) with commercial polymer polyvinyl alcohol (PVA). A solid-state fluorescence recovery was observed while loading with HCl vapors. This exclusive property of the material could be applied directly as a security ink for confidential data storage purpose. Based on above strategy, we successfully realized the rewritable application by using ISO_NDI-PVA ink and confirm its practical efficacy on various substrates by creating different patterns. The solid-state fluorescence switching behavior of ISO_NDI-PVA ink exhibited reversible on/off signal for multiple cycles under the influence of HCl/NH3 vapors. Mechanistic investigation supports a clear participation of intermolecular charge transfer (ICT) phenomenon in the solid-state fluorescence switching property. The ease of fabricating the ink with invisible to visible characteristics in response to HCl vapors provides new opportunities for exploring the application of ISO_NDI-PVA as invisible ink for targeted security applications. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.The intermolecular lattice vibrations in small-molecule organic semiconductors have a strong impact on their functional properties. Existing models treat the lattice vibrations within the harmonic approximation. In this work, polarization-orientation (PO) Raman measurements are used to monitor the temperature-evolution of the symmetry of lattice vibrations in anthracene and pentacene single crystals. Combined with first-principles calculations, it is shown that at 10 K, the lattice dynamics of the crystals are indeed harmonic. However, as the temperature is increased, specific lattice modes gradually lose their PO dependence and become more liquid-like. This finding is indicative of a dynamic symmetry breaking of the crystal structure and shows clear evidence of the strongly anharmonic nature of these vibrations. Pentacene also shows an apparent phase transition between 80 and 150 K, indicated by a change in the vibrational symmetry of one of the lattice modes. These findings lay the groundwork for accurate predictions of the electronic properties of high-mobility organic semiconductors at room temperature. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.PURPOSE Relaxation times can contribute to spectral assignment. In this study, effective T2 relaxation times ( T 2 eff ) of macromolecules are reported for gray and white matter-rich voxels in the human brain at 9.4 T. The T 2 eff of macromolecules are helpful to understand their behavior and the effect they have on metabolite quantification. Additionally, for absolute quantification of metabolites with magnetic resonance spectroscopy, appropriate T2 values of metabolites must be considered. The T2 relaxation times of metabolites are calculated after accounting for TE/sequence-specific macromolecular baselines. METHODS Macromolecular and metabolite spectra for a series of TEs were acquired at 9.4 T using double inversion-recovery metabolite-cycled semi-LASER and metabolite-cycled semi-LASER, respectively. The T2 relaxation times were calculated by fitting the LCModel relative amplitudes of macromolecular peaks and metabolites to a mono-exponential decay across the TE series. Furthermore, absolute concentrations of metabolites were calculated using the estimated relaxation times and internal water as reference.