Riberbojesen8525

nd serious consequences were observed among pediatric patients hospitalized with influenza infections than among those with COVID-19.

A considerable number of children infected with COVID-19 and H1N1 influenza were noted and reported in this study. There were no significant variations in the severity of the symptomatology and laboratory findings between the two groups of patients. Significant differences between these patients in some hospitalization factors and diagnosis upon admission also were not observed. However, more severe clinical manifestations and serious consequences were observed among pediatric patients hospitalized with influenza infections than among those with COVID-19.

Domperidone is widely used during pregnancy, although the risks associated with pregnant women have not been adequately evaluated.

The objective of this study was to compare the rate of pregnancy outcomes and congenital anomalies between pregnant women exposed and unexposed to domperidone during pregnancy.

We conducted a retrospective cohort study comparing pregnant women exposed and unexposed to domperidone during pregnancy. We used the EFEMERIS database containing the prescriptions and dispensing of drugs to pregnant women in Haute-Garonne, who had a pregnancy outcome between July 2004 and December 2017. We compared pregnant women who were exposed to domperidone at least once during pregnancy to unexposed pregnant women. Logistic regression and Cox proportional risk models were applied.

Overall, 13,964 pregnancies (10.3% of pregnancies) were given domperidone. A reduction in the number of pregnant women exposed to domperidone (2004 17.1% to 2017 1.2%) was noted. More than 75% of pregnancies were expexposed to domperidone during pregnancy have a decreased risk for natural pregnancy termination, probably owing to an indication bias.

Cross-sectional studies on the association between knowledge, attitudes, and practices of antibiotic misuse are abundant. Conversely, longitudinal studies are unavailable.

The objective of this study was to compare findings from cross-sectional and longitudinal data analyses of the same study on knowledge and attitudes related to practices of antibiotic misuse in the general adult population.

A validated knowledge, attitudes, and practices questionnaire was self-administered at baseline and participants were followed up bimonthly. Logistic regression was used on baseline data to compute adjusted odds ratios in the cross-sectional data analysis. In the longitudinal approach, Poisson regression and generalized linear mixed models were used to estimate adjusted incidence rate ratios and adjusted odds ratios, respectively.

Seven hundred and forty-seven adults completed the baseline and the follow-up questionnaires. In the cross-sectional analysis, 78 participants misused antibiotics and strong association results in our setting. Risk of bias in both analyses should be scrutinized.

Multiple sclerosis (MS) is a chronic disease associated with increased healthcare utilisation and productivity losses.

The objective of this study was to explore the progression of healthcare costs and productivity losses before and after diagnosis of MS in comparison to that of a population-based matched reference group.

We conducted a nationwide, Swedish register-based cohort study of working-aged people with MS diagnosed in 2010-12 (n = 1988) and population-based matched references without MS (n = 7981). Nine years of observation spanned from 4 years prior (Y

) to 4 years (Y

) after the year of diagnosis (Y

). Differences in annual all-cause healthcare costs (inpatient and specialised outpatient healthcare as well as pharmacy-dispensed prescribed drugs) and costs of productivity loss (days with sickness absence and disability pension) were estimated between the people with MS and references using t tests with 95% confidence intervals. The average excess costs of MS were estimated using generalised excess costs of MS over time.

Alcohol-attributable costs to society are captured by cost-of-illness studies, however estimates are often not comparable, e.g. due to the omission of relevant cost components. In this contribution we (1) summarize the societal costs attributable to alcohol use, and (2) estimate the total costs under the assumption that all cost components are considered.

A systematic review and meta-analyses were conducted for studies reporting costs from alcohol consumption for the years 2000 and later, using the EMBASE and MEDLINE databases. Cost estimates were converted into 2019 international dollars (Int$) per adult and into percentage of gross domestic product (GDP). For each study, weights were calculated to correct for the exclusion of cost indicators.

Of 1708 studies identified, 29 were included, and the mean costs of alcohol use amounted to 817.6 Int$ per adult (95% confidence interval [CI] 601.8-1033.4), equivalent to 1.5% of the GDP (95% CI 1.2-1.7%). Adjusting for omission of cost components, the economic costs of alcohol consumption were estimated to amount to 1306 Int$ per adult (95% CI 873-1738), or 2.6% (95% CI 2.0-3.1%) of the GDP. About one-third of costs (38.8%) were incurred through direct costs, while the majority of costs were due to losses in productivity (61.2%).

The identified cost studies were mainly conducted in high-income settings, with high heterogeneity in the employed methodology. check details Accounting for some methodological variations, our findings demonstrate that alcohol use continues to incur a high level of cost to many societies.

PROSPERO #CRD42020139594.

PROSPERO #CRD42020139594.There is various evidence to suggest a relationship between female hormones and meningiomas; as clinicians, we often come to face challenging situations involving female patients diagnosed with meningiomas during the post-pubertal phases of their life. We aimed to review the specific circumstances (pregnancy, postpartum, hormonal contraception and hormone replacement therapy, gender-affirming hormonal treatment) clinicians might come to face during their daily clinical practice, given the absence of available guidelines. We therefore conducted a narrative review on articles found in PubMed and Embase databases using appropriate keywords. Ninety-six relevant articles were included. The available evidence on managing meningiomas in post-pubertal women often implies personal strategies, highlighting the lack of a unified approach. The knowledge of the biological links between female hormones and meningiomas is fundamental to correctly counsel patients in various life phases. Prospective randomized studies are required to improve available guidelines on how to best manage meningiomas in female post-pubertal patients.