Wormmaclean5383

05). Within the limitations of this study, different levels of salivary MS and the consumption of different foods were observed in the low CA and high CA groups. The implications of these findings should be considered for caries susceptibility.The coronavirus disease 2019 (COVID-19) pandemic has led to the paralysis of the worldwide economy caused by the population's lockdown to stop the virus spreading, making it difficult to do exercise. The aim of this study is to analyse the commitment to and feeling of insecurity related to practising sport, sports habits and the profile of the Spanish population during lockdown according to the level of addiction to exercise. The sample consisted of 1019 subjects with a mean age of 35 years old. The variables analysed were exercise addiction, commitment to and feeling of insecurity related to sport, and sport habits. Three groups were identified according to their addiction level to exercise asymptomatic (n = 202), symptomatic (n = 756), and at risk of addiction (n = 61). The main results indicated that a higher addiction level was associated with a higher number of days and time spent on exercise per week. Six percent of the subjects were at addiction risk, and they had a lower feeling of insecurity towards sport. These findings provide information to governments on the need to promote physical activity programmes at home to promote adequate fitness and mental wellbeing in the population.Polyphenolic enriched extracts from two species of Cyperus, Cyperus glomeratus and Cyperus thunbergii, possess mammalian arginase inhibitory capacities, with the percentage inhibition ranging from 80% to 95% at 100 µg/mL and 40% to 64% at 10 µg/mL. Phytochemical investigation of these species led to the isolation and identification of two new natural stilbene oligomers named thunbergin A-B (1-2), together with three other stilbenes, trans-resveratrol (3), trans-scirpusin A (4), trans-cyperusphenol A (6), and two flavonoids, aureusidin (5) and luteolin (7), which were isolated for the first time from C.thunbergii and C. glomeratus. Structures were established on the basis of the spectroscopic data from MS and NMR experiments. The arginase inhibitory activity of compounds 1-7 was evaluated through an in vitro arginase inhibitory assay using purified liver bovine arginase. As a result, five compounds (1, 4-7) showed significant inhibition of arginase, with IC50 values between 17.6 and 60.6 µM, in the range of those of the natural arginase inhibitor piceatannol (12.6 µM). In addition, methanolic extract from Cyperus thunbergii exhibited an endothelium and NO-dependent vasorelaxant effect on thoracic aortic rings from rats and improved endothelial dysfunction in an adjuvant-induced arthritis rat model.(1) Background This study evaluated the clinical outcome after salvage radiotherapy for first pelvic relapse after endometrial cancer (EC). (2) Methods This multicenter retrospective study included EC patients with first central pelvic relapse without lymph node involvement treated with curative intent. Progression-free (PFS) and overall survival (OS) were calculated with the Kaplan-Meier method and possible predictive factors for risk of relapse and mortality were identified using the Cox model. (3) Results We included 139 patients with median EQD2 (Equivalent Dose in 2 Gy fractions) to the clinical target volume of 70.0 Gy. During follow up of median 6.66 years, 39.6% patients developed a second relapse. Risk group classification at primary diagnosis based on histology, grading and FIGO stage and how the pelvic tumor boost was administered were independently associated with PFS and OS. Five-year OS was 68% (95% CI (59-75)) for the whole cohort. Five-year OS was 88% (95% CI (75-94)), 72% (95% CI (55-84)) and 38% (95% CI (15-60)) for the stage I low-, intermediate- and high-risk group, respectively. (4) Conclusions The majority of central pelvic recurrences in RT-naive EC women can be successfully salvaged with radiotherapy. However, survival in patients with high-risk disease remains poor and warrants a more individualized approach to optimize outcome.Additive manufacturing (AM) has gained increasing attention over the past years due to its fast prototype, easier modification, and possibility for complex internal texture devices when compared to traditional manufacture processing. However, potential internal defects are occurring during AM processes, and it requires real-time inspections to minimize the costs by either aborting the processing or repairing the defect. In order to perform the defects inspection, first the defects database NEU-DET is used for training. Then, a convolution neural network (CNN) is applied to perform defects classification. For real-time purposes, Field Programmable Gate Arrays (FPGAs) are utilized for acceleration. A binarized neural network (BNN) is proposed to best fit the FPGA bit operations. Finally, for the image labeled with defects, the selective search and non-maximum algorithms are implemented to help locate the coordinates of defects. Experiments show that the BNN model on NEU-DET can achieve 97.9% accuracy in identifying whether the image is defective or defect-free. As for the image classification speed, the FPGA-based BNN module can process one image within 0.5 s. The BNN design is modularized and can be duplicated in parallel to fully utilize logic gates and memory resources in FPGAs. It is clear that the proposed FPGA-based BNN can perform real-time defects inspection with high accuracy and it can easily scale up to larger FPGA implementations.The kidney is threatened by a lot of potentially toxic substances. To study the influence of the nephrotoxin ochratoxin A (OTA) we established a cell co-culture model consisting of human renal proximal tubule cells and fibroblasts. We studied the effect of OTA on cell survival, the expression of genes and/or proteins related to cell death, extracellular matrix and energy homeostasis. OTA-induced necrosis was enhanced in both cell types in the presence of the respective other cell type, whereas OTA-induced apoptosis was independent therefrom. In fibroblasts, but not in tubule cells, a co-culture effect was visible concerning the expression of the cell-cycle-related protein p21. The expression of the epithelial-to-mesenchymal transition-indicating protein vimentin was independent from the culture-condition. Lixisenatide molecular weight The expression of the OTA-induced lncRNA WISP1-AS1 was enhanced in co-culture. OTA exposure led to alterations in the expression of genes related to energy metabolism with a glucose-mobilizing effect and a reduced expression of mitochondrial proteins.