Kearnssavage3208

KOMPSAT-3, a Korean earth observing satellite, provides the panchromatic (PAN) band and four multispectral (MS) bands. They can be fused to obtain a pan-sharpened image of higher resolution in both the spectral and spatial domain, which is more informative and interpretative for visual inspection. In KOMPSAT-3 Advanced Earth Imaging Sensor System (AEISS) uni-focal camera system, the precise sensor alignment is a prerequisite for the fusion of MS and PAN images because MS and PAN Charge-Coupled Device (CCD) sensors are installed with certain offsets. In addition, exterior effects associated with the ephemeris and terrain elevation lead to the geometric discrepancy between MS and PAN images. Therefore, we propose a rigorous co-registration of KOMPSAT-3 MS and PAN images based on physical sensor modeling. We evaluated the impacts of CCD line offsets, ephemeris, and terrain elevation on the difference in image coordinates. The analysis enables precise co-registration modeling between MS and PAN images. An experiment with KOMPSAT-3 images produced negligible geometric discrepancy between MS and PAN images.Aplastic anemia is a rare blood disease characterized by the destruction of the hematopoietic stem cells (HSC) in the bone marrow that, in the majority of cases, is caused by an autoimmune reaction. Patients with aplastic anemia are treated with immunosuppressive drugs and some of them, especially younger individuals with a donor available, can be successfully treated with hematopoietic stem cell transplantation (HSCT). We report here a rare case of post-transplant lymphoproliferative disorder (PTLD) associated with Epstein-Barr virus (EBV) reactivation in a 30-year-old female patient who underwent allogeneic HSCT for severe aplastic anemia. The PTLD, which was diagnosed 230 days after transplantation, was localized exclusively in the central nervous system (specifically in the choroid plexus) and manifested with obvious signs of intracranial hypertension. After receiving three cycles of high dose methotrexate (HD-MTX) combined with rituximab, the patient achieved a complete clinical recovery with normalization of blood cell counts, no evidence of EBV reactivation, and no associated neurotoxicity.Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the world. The risk of AMD increases with age and is most common among the white population. Here, we discuss the convergence of factors related to race, pigmentation, and susceptibility to AMD, where the primary defect occurs in retinal support cells, the retinal pigment epithelium (RPE). We explore whether the observed racial bias in AMD incidence is related to innate differences in the basal level of pigmentation between races, and whether the pigmentation pathway activity in the RPE might protect from retinal degeneration. More specifically, we explore whether the downstream signaling activity of GPR143, a G-protein coupled receptor in the pigmentation pathway, might underly the racial bias of AMD and be a target to prevent the disease. Lastly, we summarize the past findings of a large retrospective study that investigated the relationship between the stimulation of GPR143 with L-DOPA, the pigmentation pathway, and AMD, to potentially help develop new ways to prevent or treat AMD. The reader of this review will come to understand the racial bias of AMD, which is related to the function of the RPE.Hepatocellular carcinoma (HCC), including hepatitis C virus (HCV)-induced HCC, is a deadly disease highly refractory to chemotherapy, thus requiring the continuous identification of novel treatment strategies. selleck compound Berberine (BBR) has been previously reported to inhibit hepatoma cell growth, but the main type of cell death elicited by BBR, and whether the alkaloid can inhibit hepatoma cells carrying HCV genomes, is unclear. Herein, we show that BBR treatment induced a biphasic cell death irrespective of the presence of HCV subgenomic replicon RNA, first triggering apoptosis that then progressed to necrosis between 24 and 48 h post-treatment. Furthermore, BBR treatment potentiated the HCV replicon-induced reactive oxygen species (ROS) production, inhibition of which with an antioxidant attenuated the cell death that was elicited by BBR in these cells. Moreover, BBR dampened the autophagic response in HCV RNA-positive or negative hepatoma cells, and pharmacological inhibition of autophagy conversely augmented the BBR-induced cell death. Finally, BBR inhibited the growth of Huh-7 cells that were persistently infected with the full-length genome HCV particles, and concomitant pharmacological inhibition of autophagy potentiated the killing of these cells by BBR. Our findings suggest that combining BBR with the inhibition of autophagy could be an attractive treatment strategy against HCC, irrespective of the presence of the HCV genome.This paper presents a new proposal to generate optimal pseudorandom numbers with Gaussian distribution. The generator is especially designed for low-cost hardware implementation, although the software version is also considered. For this reason, Linear Feedback Shift Registers in conjunction with cyclic rotations are employed. The proposal presents a low implementation cost and overcomes the limitations of the previous Gaussian generators based on linear feedback shift registers by means of a less complex algorithm to find optimal configurations. As a consequence, it turns into a really usable generator. Moreover, a further improvement, based on the simulated annealing algorithm, is applied in order for the random values to be better adjusted to the normal distribution.The properties of hybrid self-reinforced composite (SRC) materials based on ultra-high molecular weight polyethylene (UHMWPE) were studied. The hybrid materials consist of two parts an isotropic UHMWPE layer and unidirectional SRC based on UHMWPE fibers. Hot compaction as an approach to obtaining composites allowed melting only the surface of each UHMWPE fiber. Thus, after cooling, the molten UHMWPE formed an SRC matrix and bound an isotropic UHMWPE layer and the SRC. The single-lap shear test, flexural test, and differential scanning calorimetry (DSC) analysis were carried out to determine the influence of hot compaction parameters on the properties of the SRC and the adhesion between the layers. The shear strength increased with increasing hot compaction temperature while the preserved fibers' volume decreased, which was proved by the DSC analysis and a reduction in the flexural modulus of the SRC. The increase in hot compaction pressure resulted in a decrease in shear strength caused by lower remelting of the fibers' surface.