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Clinicians must be aware of this possibility, particularly if cognitive and/or psychiatric symptoms occurred after a remitting period. In our two cases, only rituximab was associated with clinical improvement. Copyright © 2020 Dorcet, Benaiteau, Bost, Mengelle, Bonneville, Martin-Blondel and Pariente.Background Progressive intellectual and neurological deterioration (PIND) is a rare but severe childhood disorder characterized by loss of intellectual or developmental abilities, and requires quick diagnosis to ensure timely treatment to prevent possible irreversible neurological damage. Inborn errors of metabolism (IEMs) constitute a group of more than 1,000 monogenic conditions in which the impairment of a biochemical pathway is intrinsic to the pathophysiology of the disease, resulting in either accumulation of toxic metabolites and/or shortage of energy and building blocks for the cells. Many IEMs are amenable to treatment with the potential to improve outcomes. With this literature review we aim to create an overview of IEMs presenting with PIND in children, to aid clinicians in accelerating the diagnostic process. Methods We performed a PubMed search on IEMs presenting with PIND in individuals aged 0-18 years. We applied stringent selection criteria and subsequently derived information on encoding genePIND conditions and have the advantage of detectable biomarkers as well as amenability to treatment. Thus, the clinician should keep IEMs at the forefront of the diagnostic workup of a child with PIND. With the ongoing discovery of new IEMs, expanded phenotypes, and novel treatment strategies, continuous updates to this work will be required. Copyright © 2020 Warmerdam, Termeulen-Ferreira, Tseng, Lee, van Eeghen, Ferreira and van Karnebeek.Stem cells have become a powerful tool in the treatment of many diseases owing to their regenerative ability and rapid promotion of development in regenerative medicine such as in traumatic brain injury. However, the high level of oxidant micro-environment in lesion region leads to more than 99% cells into death. In this study, we used genetic methods to edit Keap1 gene in mesenchymal stem cells, we and observed their antioxidative ability. First, we disturbed the start codon and the 376th amino acid codon of Keap1 in adipose-derived mesenchymal stem cells (Ad-MSCs) with CRISPR/Cas9, respectively, to release Nrf2 from the binding of Keap1. As a result, Nrf2 was activated and localized into nuclei and regulated cellular anti-oxidation. We observed that the cells lacking Keap1 ATG codon showed obvious nuclear localization of Nrf2. Besides lower expression of Bax-1 and lower content of malondialdehyde (MDA) were detected after H2O2 treatment, we also found higher expression of Bcl-2 in Keap1 ATG codon knock-out cells, whereas a higher expression of PCNA was observed only in the Keap1 376th codon-edited cells, whose Bax-1 expression was lower than that in the control cells. Our study revealed that loss of Keap1 resulted in anti-oxidative ability in Ad-MSCs, suggesting that our strategy can hopefully increase the viability of mesenchymal stem cells after grafting. This study is also a frontier exploration to the application of CRISPR/Cas9 in Ad-MSCs. Copyright © 2020 Hu, Liu and Zhu.The policy statement for evidence-based practice in psychology is the most important document in contemporary psychotherapy. In its current form, evidence-based practice in psychology gives scientific research precedence in psychotherapy practice. However, psychotherapy practice's complexity warrants reflection beyond the limits of science. The importance of clinical expert is not recognised in the current policy statement. The clinical expert is necessary to translate psychological research into clinical practice. It is also crucial to identify, clarify and include patient preferences in psychotherapy practice. This paper argues that virtue ethics is a useful theoretical framework for conceptualising clinical expertise. Clinical expertise is conceptualised as the meta-capacity of practical wisdom (phronesis) and the virtues necessary for integrating best available research, clinical expertise and patient preferences. Copyright © 2020 Berg.Research on youth transitions, and the well-being of young people, has to take into consideration the digital context in which they are immersed. Digital interaction of young people increase year by year, social networking sites play a key role in their personal and professional relationships, and a very high percentage of jobs require digital skills. According to Eurostat (2019), participating on social networking sites (one of the most common online activities in the EU-28), is growing every year [more than half (56%) of individuals aged 16-74 used the internet for social networking sites], and this percentage increases among the younger generations. In this article, we present the results of our research on the digital skills and well-being of young people on Facebook, based on a survey with a sample of 126 young people graduated from the University of Málaga (School of Social Work) (Spain). Based on certain scales, the level of digital skills that students have on Facebook was measured, considering strategic aspects for information search, level of use and presence of Facebook in life, maintenance of relations and tolerance to diversity. Variables of psychosocial well-being were also measured (social capital, self-esteem, life satisfaction, and personal well-being). Variables of digital skills on Facebook were subsequently related to well-being variables. Inhibitor Library Results show that certain digital skills relate to the well-being of young people. In this sense, we deem it crucial to develop education policies that could provide young graduates with general digital skills to be used on social networking sites. Copyright © 2020 Castillo de Mesa, Gómez-Jacinto, López Peláez and Erro-Garcés.Initial evidence suggests that cultural differences have consequences for wise reasoning (perspective taking, consideration of change and alternatives, intellectual humility, search for compromise, and adopting an outsider's vantage point), with more reports of wise reasoning about interpersonal conflicts among Japanese (as compared to American) young and middle-aged adults. Similarly, we found that people from the rice-farming area of southern China also exhibited greater wise reasoning when they encountered conflicts with a friend or in the workplace than those from the wheat-farming area of northern China (N = 487, 25 provinces). The relationship between rice farming and wise reasoning was mediated by loyalty/nepotism. This research advances study of the relationship between wisdom and culture. It also provides evidence for the influence of social-ecological factors on wisdom and culture. Copyright © 2020 Wei and Wang.