Whitakergentry7658

Ga-PSMA PET/CT has high specificity and sensitivity for the detection of both intraprostatic tumor focal lesions and metastasis. However, approximately 10% of primary prostate cancer are invisible on PSMA-PET (exhibit no or minimal uptake). In this work, we investigated whether machine learning-based radiomics models derived from PSMA-PET images could predict invisible intraprostatic lesions on

Ga-PSMA-11 PET in patients with primary prostate cancer.

In this retrospective study, patients with or without prostate cancer who underwent

Ga-PSMA PET/CT and presented negative on PSMA-PET image at either of two different institutions were included institution 1 (between 2017 and 2020) for the training set and institution 2 (between 2019 and 2020) for the external test set. Three random forest (RF) models were built using selected features extracted from standard PET images, delayed PET images, and both standard and delayed PET images. Then, subsequent tenfold cross-validation was performed. In the test phasedels developed by

Ga-PSMA-11 PET-based radiomics features were proven useful for accurate prediction of invisible intraprostatic lesion on

Ga-PSMA-11 PET in patients with primary prostate cancer and showed better diagnostic performance compared with PSAD.

Random forest models developed by 68 Ga-PSMA-11 PET-based radiomics features were proven useful for accurate prediction of invisible intraprostatic lesion on 68 Ga-PSMA-11 PET in patients with primary prostate cancer and showed better diagnostic performance compared with PSAD.Climate change is increasingly becoming a threat to a wide range of community livelihoods in the agro-pastoral systems across scales. Hence, recovery from impacts caused by climate change requires rational decisions, particularly how resources and activities can be mobilized to enhance resilience. In this paper, we track pathways to recovery from such climate shocks in the agro-pastoral systems in three villages; Naitolia, MwakiniJuu and MswakiniChini in northern Tanzania. A mixed methods approach was used that entailed 120 questionnaire respondents and three focus group discussion sessions, one in each village. Our findings show that livelihood assets and activities are inadequate to buffer the impacts of climate change. Despite rules and regulations that guide resource utilization; communities will continue facing climate related impacts. This is due to inherent cultural dispositions that hinder transformation from one form of livelihood assets to the other. This restricts the reception of new frontiers of experiential knowledge that would allow for livelihood diversification outside the climate dependence scenario even after the occurrence of climate hazards. We argue that any attempt of building the resilience of any social-ecological system must consider the cultural backgrounds of the communities in which resilience building is sought.We studied the impact of the new fenced and accident-safe motorway on the mortality of European badgers Meles meles on local roads in western Poland in 2010-2015. We monitored the badgers mortality on local roads of three categories main roads, secondary roads and county roads. The study was conducted before and after the opening of the motorway in 2012. We hypothesized that the mortality of badgers is lower due to traffic concentration on motorway. Ninety two badgers were killed in collisions with vehicles on all monitored roads. Mean number of killed badgers was lowest in 2010 before the motorway opening and the highest in 2012. The mortality of badgers on regional roads was highest after the opening of the motorway due to the changes in traffic on the access roads. Within the road network, the mortality of badgers was 5.8 individuals/10 km of road per whole study period with the highest rate on main roads 8.5 individuals/10 km. The badgers mortality was highest on county roads but it was lower than expected in relation to the road network density. The highest vehicle collision risk for badgers of both sexes occurred in June. Distance to human settlements was the only environmental factor that was positively related to badger mortality on roads. We conclude that the new motorway did not reduce the mortality rate of badgers on the adjacent roads because the status of local roads has changed and now they mainly function as access roads to the motorway.Wetlands are often located in landscape positions where they receive runoff or floodwaters, which may contain toxic trace metals and other pollutants from anthropogenic sources. Over time, this can lead to the accumulation of potentially harmful levels of metals in wetlands soils. To assess the potential risk of Cu and Zn buildup in wetland soils in North Carolina, soil data from 88 wetlands were analyzed. In a subset of 16 wetlands, more intensive sampling was conducted. Samples were analyzed for Mehlich 3 Cu and Zn, and a subset of the samples was analyzed for total Cu and Zn. Overall, Mehlich 3 Cu and Zn were low, with mean values of 0.9 mg/kg for Cu and 3.2 mg/kg for Zn. Warning levels for Mehlich 3 Zn were only exceeded in three of the 88 sites; elevated Mehlich Cu was not observed. Total Cu and Zn were also low, with only a few sites having elevated levels; however, there was not a strong linear relationship between Mehlich 3 and total metals. Mean levels of Mehlich 3 Cu and Zn in wetlands were much lower than for human-impacted upland soils and background threshold concentrations that might be indicative of disturbance were much lower than warning levels for agricultural soils. The very low mobile Zn and Cu in most of these wetlands indicated that these metals do not pose a risk to the biota in most North Carolina wetlands, but wetlands with a direct and significant anthropogenic source of metal contamination could be exceptions.

Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual's sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning.

Healthy adults' data (N = 953 [41% twins]) were analysed from the PREDICT dietary intervention trial. selleck Participants consumed isoenergetic standardised meals over 2weeks in the clinic and at home. Actigraphy was used to assess sleep variables (duration, efficiency, timing) and continuous glucose monitors were used to measure glycaemic variation (>8000 meals).

Sleep variables were significantly associated with postprandial glycaemic control (2h incremental AUC), at both between- and within-person levels. Sleep period time interacted with meal type, with a smaller effect of poor sleep on postprandial blood glucose levels when high-carbohydrate (low fat/protein) (p

 = 0.02) and high-fat (p

 = 0.03) breakfasts were consumnd later bedtime routines are associated with more pronounced postprandial glycaemic responses to breakfast the following morning. A person's deviation from their usual sleep pattern was also associated with poorer postprandial glycaemic control. These findings underscore sleep as a modifiable, non-pharmacological therapeutic target for the optimal regulation of human metabolic health. Trial registration ClinicalTrials.gov NCT03479866.

This study identified the historical geoclimatic factors which caused low genetic diversity and strong phylogeographic structure in a cryptoviviparous mangrove. The phylogeographic pattern was used to suggest conservation actions. Phylogeographic studies are used to understand the spatial distribution and evolution of genetic diversity, and have major conservation implications, especially for threatened taxa like the mangroves. This study aimed to assess the phylogeographic pattern of Aegiceras corniculatum, a cryptoviviparous mangrove, across its distribution range in the Indo-West Pacific (IWP) region. We genotyped 398 samples, collected from 37 populations, at four chloroplast DNA (cpDNA) loci, and identified the influence of historical processes on the contemporary population structure of the species. Low genetic diversity at the population level was observed. The evolutionary relationship between 12 cpDNA haplotypes suggested a strong phylogeographic structure, which was further validated by the clusteon.

The maximum number of vertebral bodies with bony bridges between adjacent vertebrae (max VB) helps assess the risk of fracture in diffuse idiopathic skeletal hyperostosis (DISH). In addition to max VB, the maximum thickness of bone cross-bridges (max TB) may be an index of bone mineral density (BMD). Therefore, this study investigated the relationship among max VB, max TB, and BMD.

The participants in this cross-sectional study were male patients (n = 123) with various max VB from the thoracic vertebrae to the sacrum without sacroiliac ankylosis. The participants were grouped by max VB. For example, a group with max VB from 4 to 8 would be listed as max VB (4-8). The relation between femur proximal BMD and mean max TB and max VB was assessed. Femur proximal BMD was then compared after adjusting for confounding factors.

The results indicated that max VB was correlated with femur proximal BMD in max VB (0-8) and max VB (9-18) groups. The mean max TB was correlated only with femur proximal BMD in max VB (0-8). After adjusting, max VB (4-8) showed a significantly higher femur proximal BMD than max VB (0-3) and max VB (9-18).

Femur proximal BMD and mean max TB showed different trends after max VB = 9, which suggests that max VB is an index of BMD, and that DISH has at least two possible populations in terms of BMD and bone cross-link thickness.

Femur proximal BMD and mean max TB showed different trends after max VB = 9, which suggests that max VB is an index of BMD, and that DISH has at least two possible populations in terms of BMD and bone cross-link thickness.

Work-related musculoskeletal disorders (WMSDs) are common occupational problems affecting the health and productivity of workers worldwide. Ergonomic intervention programs (EIPs) can play an effective role in preventing these disorders in the workplace. Assessing the effectiveness of an EIP is a challenge faced by both industries and researchers. This study was aimed at assessing the effectiveness of an EIP on human resources productivity (HRP), musculoskeletal disorders (MSDs), general health and occupational fatigue in a steel industry.

This study was conducted in a steel industry in Isfahan, Iran, between 2018 and 2021. To assess the effectiveness of the EIP with a participatory approach, training and redesign of workstations, the criteria of HRP, MSDs, general health and occupational fatigue were investigated before and after the intervention, using HRP Questionnaire, Nordic musculoskeletal questionnaire (NMQ), 28-item General Health Questionnaire (28-GHQ), Swedish Occupational Fatigue Inventory (SOFI-20) and Occupational Fatigue/Exhaustion Recovery (OFER-15) Questionnaire, as data collection tools, respectively.

The implementation of EIP in the studied industry significantly led to an increase in HRP (p < 0.05). The prevalence of MSDs decreased significantly in most regions of the body after the interventions (p < 0.001). In addition, the program significantly improved general health (p < 0.001) and reduced occupational fatigue among employees (p < 0.001).

The implementation of EIP was significantly effective in working conditions improvement. Therefore, implementing EIP with participatory approach, workforce training, as well as redesigning of workstations are recommended in industries.

The implementation of EIP was significantly effective in working conditions improvement. Therefore, implementing EIP with participatory approach, workforce training, as well as redesigning of workstations are recommended in industries.