Buurmccoy5601

Lithium loss during the initial charge process inevitably reduces the capacity and energy density of lithium-ion batteries. find more Cathode additives are favored with respect to their controllable prelithiation degree and scalable application; however, the insulating nature of their delithiation products retards electrode reaction kinetics in subsequent cycles. link2 Herein, we propose a prelithiation separator by modifying a commercial separator with a Li2S/Co nanocomposite to compensate for the initial capacity loss. The Li2S/Co coating layer extracts active lithium ion during the charge process and shows a delithiation capacity of 993 mA h g-1. When paired with a LiFePO4|graphite full cell, the reversible capacity is increased from 112.6 to 150.3 mA h g-1, leading to a 29.5% boost in the energy density. The as-prepared pouch cell also demonstrates a stable cycling performance. The excellent electrochemical performance and the scalable production of the prelithiation separator reveal its great potential in lithium-ion battery industry application.Aqueous zinc-ion batteries (ZIBs) with cost-effective and safe features are highly competitive in grid energy storage applications, but plagued by the sluggish Zn2+ diffusion kinetics and poor cyclability of cathodes. Herein, a one-stone-two-birds strategy of La3+ incorporation (La-V2O5) is developed to motivate Zn2+ insertion/extraction kinetics and stabilize vanadium species for V2O5. Theoretical and experimental studies reveal the incorporated La3+ ions in V2O5 can not only serve as pillars to expand the interlayer distance (11.77 Å) and lower the Zn2+ migration energy barrier (0.82 eV) but also offer intermediated level and narrower band gap (0.54 eV), thus accelerating the electron/ion diffusion kinetics. Importantly, the steadily doped La3+ ions effectively stabilize the V-O bonds by shortening the bond length, thereby inhibiting vanadium species dissolution. link3 Therefore, the resulting La-V2O5-ZIBs deliver an exceptional rate capacity of 405 mA h g-1 (0.1 A g-1), long-term stability with 93.8% retention after 5000 cycles (10 A g-1), and extraordinary energy density of 289.3 W h kg-1, outperforming various metal-ions-doped V2O5 cathodes. Moreover, the La-V2O5 pouch cell presents excellent electrochemical performance and impressive flexibility and integration ability. The strategies of incorporating rare-earth-metal ions provide guidance to other well-established aqueous ZIBs cathodes and other advanced electrochemical devices.Cryptosporidiosis is caused by infection of the small intestine by Cryptosporidium parasites, resulting in severe diarrhea, dehydration, malabsorption, and potentially death. The only FDA-approved therapeutic is only partially effective in young children and ineffective for immunocompromised patients. Triazolopyridazine MMV665917 is a previously reported anti-Cryptosporidium screening hit with in vivo efficacy but suffers from modest inhibition of the hERG ion channel, which could portend cardiotoxicity. Herein, we describe our initial development of structure-activity relationships of this novel lead series with a particular focus on optimization of the piperazine-urea linker. We have discovered that piperazine-acetamide is a superior linker resulting in identification of SLU-2633, which has an EC50 of 0.17 μM, an improved projected margin versus hERG, prolonged pharmacokinetic exposure in small intestine, and oral efficacy in vivo with minimal systemic exposure. SLU-2633 represents a significant advancement toward the identification of a new effective and safe treatment for cryptosporidiosis.Sn-based materials have been popularly researched as anodes for energy storage due to their high theoretical capacity. However, the sluggish reaction kinetics and unsatisfied cycling stability caused by poor conductivity and dramatic volume expansion are still pivotal barriers for the development of Sn-based materials as anodes. In this work, the binary-metal Mn2SnO4 nanoparticles and Sn encapsulated in N-doped carbon (Sn@Mn2SnO4-NC) were fabricated by multistep reactions and employed as the anode for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). The coexistence of binary metals (Sn and Mn) can improve intrinsic conductivity. Simultaneously, hollow architecture along with carbon relieves internal stress and prevents structural collapse. A Sn@Mn2SnO4-NC anode delivers an appealing capacity of 1039.5 mAh g-1 for 100 cycles at 100 mA g-1 and 823.8 mAh g-1 for 600 cycles at 1000 mA g-1 in LIBs. When evaluated as an anode in SIBs, the Sn@Mn2SnO4-NC anode tolerates up to 7000 cycles at 2000 mA g-1 and maintains a capacity of 185.8 mAh g-1. Quantified kinetic investigations demonstrate the high contribution of pseudocapacitive effects during the cycle process. Furthermore, density functional theory (DFT) calculations further verify that introduction of the second metal (Mn) improves the conductivity of the material, which is favorable for charge transport. This work is expected to provide a feasible preparation strategy for binary-metal materials to enhance the performance of lithium- and sodium-ion batteries.Non-dioxin-like polychlorinated biphenyls (ndl-PCBs) are a subclass of persistent bioaccumulative pollutants able to enter the food chain. We investigated the transfer of ndl-PCBs from contaminated feed into meat and liver of fattening chickens. A total of 48 chicks were divided into five treatment and one control groups. Treated animals were fed with contaminated diets (11.7 ± 0.4 μg/kg sum of indicator ndl-PCBs; 88% dry matter (DM)) before slaughter for different subperiods of time 16, 23, 28, 32, and 36 days for groups 1-5, respectively. One day after the end of each subperiod, three animals per group were slaughtered to determine the congener-specific ndl-PCB content. All remaining animals were fed the control feed until slaughter on day 37 to probe depuration. We used these data to generate congener-specific physiologically based toxicokinetic (PBTK) models for indicator ndl-PCBs. The models show that PCBs 28, 138, 153, and 180 form a more slowly eliminated cluster (with an observed transfer rate into meat over 74% and observed half-lives over 8.7 days) than PCBs 52 and 101 (with a transfer rate under 13% and half-lives under 2.6 days). Our simulations show that ndl-PCB levels in feed lower than 3.9 (long 56-day) or 4.4 μg/kg (short 37-day fattening period) would be necessary to ensure the current maximum level in muscle meat (fat basis), according to EU Regulations 1881/2006 and 1259/2011. The PBTK models are made available in the Python and Food Safety Knowledge Exchange formats.Predictive models for micropollutant removal by membrane separation are highly desirable for the design and selection of appropriate membranes. While machine learning (ML) models have been applied for such purposes, their reliability might be compromised by data leakage due to inappropriate data splitting. More importantly, whether ML models can truly understand the mechanisms of membrane separation has not been revealed. In this study, we evaluate the capability of the XGBoost model to predict micropollutant removal efficiencies of reverse osmosis and nanofiltration membranes. Our results demonstrate that data leakage leads to falsely high prediction accuracy. By utilizing a model interpretation method based on the cooperative game theory, we test the knowledge of XGBoost on the mechanisms of membrane separation via quantifying the contributions of input variables to the model predictions. We reveal that XGBoost possesses an adequate understanding of size exclusion, but its knowledge of electrostatic interactions and adsorption is limited. Our findings suggest that future work should focus more on avoiding data leakage and evaluating the mechanistic knowledge of ML models. In addition, high-quality data from more diverse experimental conditions, as well as more informative variables, are needed to improve the accuracy of ML models for predicting membrane performance.Multidrug resistance against conventional antibiotics poses an important threat to human health. In this context, antimicrobial peptides (AMPs) have been extensively studied for their antibacterial activity and promising results have been shown so far. However, AMPs tend to be rather vulnerable to protease degradation, which offsets their therapeutic appeal. Here, we demonstrate how replacing functional residues in the antimicrobial region of human RNase 3-also named eosinophil cationic protein-by non-natural amino acids increases stability in human serum. These changes were also shown to reduce the hemolytic effect of the peptides in general terms, whereas the antimicrobial activity was reasonably preserved. Digestion profiles enabled us to design new peptides with superior stability and lower toxicity that could become relevant candidates to reach clinical stages."Multi-action" Pt(IV) derivatives of cisplatin with combretastatin A4 (CA4) bioactive ligands that are conjugated to Pt(IV) by carbonate are unique because the ligand (IC50 less then 10 nM) is dramatically 1000-folds more cytotoxic than cisplatin in vitro. The Pt(IV)-CA4 prodrugs were as cytotoxic as CA4 itself, indicating that the platinum moiety probably plays an insignificant role in triggering cytotoxicity, suggesting that the Pt(IV)-CA4 complexes act as prodrugs for CA4 rather than as true multi-action prodrugs. In vivo tests (Lewis lung carcinoma) show that ctc-[Pt(NH3)2(PhB)(CA4)Cl2] inhibited tumor growth by 93% compared to CA4 (67%), cisplatin (84%), and 111 cisplatin/CA4/PhB (85%) while displaying less then 5% body weight loss compared to cisplatin (20%) or CA4 (10%). In this case, and perhaps with other extremely potent bioactive ligands, platinum(IV) acts merely as a self-immolative carrier triggered by reduction in the cancer cell with only a minor contribution to cytotoxicity.An effective and precise electrochemiluminescence resonance energy transfer (ECL-RET), including the efficient regulation over the proximity of a donor and an acceptor and the reliable stimuli responsive as well as the avoidance of undesirable probes leakage, etc., is significant for the development of an accurate and sensitive ECL detection method; yet, the current literature in documentation involves only a limited range of such ECL-RET systems. Herein, we propose an ECL-RET strategy with dually quenched ultralow background signals and a dual-stimuli responsive, accurate signal output for the ultrasensitive and reliable detection of anatoxin-a (ATX-a). The dual quenching is accomplished by an integrated ECL-RET probe of metal organic frameworks (MOFs) encapsulated into Ru(bpy)32+ (Ru-MOF) (donor) coated with silver nanoparticles (AgNPs) shell (acceptor 1) and close proximity with DNA-ferrocene (Fc) (acceptor 2). Multistimuli responsive DNAzyme facilitated the accurate signal switch by both target ATX-a and ect in complicated sample analysis.Controlling supramolecular polymerization is of fundamental importance to create advanced materials and devices. Here we show that the thermodynamic equilibrium of Gd3+-bearing supramolecular rod networks is shifted reversibly at room temperature in a static magnetic field of up to 2 T. Our approach opens opportunities to control the structure formation of other supramolecular or coordination polymers that contain paramagnetic ions.