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35); OR = 1.12 (95 %CI1.09, 1.15); OR = 1.05 (95 %CI1.02, 1.07)]. Meanwhile, the pollutant-health associations were more apparent in medium-urbanized areas compared to low- and high-urbanized areas. For instance, a 10-μg/m3 increase in PM2.5 concentration at 2-year moving average was associated with increased odds of CKD in the areas with NLI level in the second [OR = 2.78 (95 %CI1.77, 4.36)] and third quartiles [OR = 1.49 (95 %CI1.14, 1.95)], compared to the lowest [OR = 0.96 (95% CI 0.73, 1.26)] and highest [OR = 0.63 (95% CI 0.39-1.02)] quartiles. DPCPX in vivo PM2.5 and NO2 were associated with increased odds of CKD prevalence, especially in areas with medium NLI levels, suggesting the necessity of strengthening environmental management in medium-urbanized regions.To effectively incorporate in vitro-in silico-based methods into the regulation of consumer product safety, a quantitative connection between product phthalate concentrations and in vitro bioactivity data must be established for the general population. We developed, evaluated, and demonstrated a modeling framework that integrates exposure and pharmacokinetic models to convert product phthalate concentrations into population-scale risks for phthalates and their substitutes. A probabilistic exposure model was developed to generate the distribution of multi-route exposures based on product phthalate concentrations, chemical properties, and human activities. Pharmacokinetic models were developed to simulate population toxicokinetics using Bayesian analysis via the Markov chain Monte Carlo method. Both exposure and pharmacokinetic models demonstrated good predictive capability when compared with worldwide studies. The distributions of exposures and pharmacokinetics were integrated to predict the population distribe these in vitro-in silico-based risk assessments for a broad range of products containing an equally broad range of chemicals.The major human cytochrome P450 CYP2D6 isoform enzyme plays important roles in the liver and in the brain with regards to xenobiotic metabolism. Xenobiotics as CYP2D6 substrates include a whole range of pharmaceuticals, pesticides and plant alkaloids to cite but a few. In addition, a number of endogenous compounds have been shown to be substrates of CYP2D6 including trace amines in the brain such as tyramine and 5-methoxytryptamine as well as anandamide and progesterone. Because of the polymorphic nature of CYP2D6, considerable inter-phenotypic and inter-ethnic differences in the pharmaco/toxicokinetics (PK/TK) and metabolism of CYP2D6 substrates exist with potential consequences on the pharmacology and toxicity of chemicals. Here, large extensive literature searches have been performed to collect PK data from published human studies for a wide range of pharmaceutical probe substrates and investigate human variability in CYP2D6 metabolism. The computed kinetic parameters resulted in the largest open source daof quantitative in vitro in vivo extrapolation models.

Prenatal cadmium exposure has been associated with adverse neurodevelopmental outcomes. However, previous findings are contradictory, and little is known about the potential modifiers of the cadmium-related neurodevelopmental risk. We investigated the associations between prenatal cadmium exposure and neurodevelopment in 2-year-old children and examined the influence of mother/child characteristics.

We recruited 3545 mother-child pairs from the Japan Environment and Children's Study. We collected maternal blood during mid/late pregnancy and cord blood at delivery, and measured cadmium concentrations using inductively coupled plasma mass spectrometry. Neurodevelopment was assessed using the Kyoto Scale of Psychological Development (KSPD), which includes cognitive-adaptive (C-A), language-social (L-S), postural-motor (P-M) and developmental quotient (DQ) domains. Associations between cadmium and KSPD scores were tested using multivariable models after controlling for confounders.

Median levels (interquart, in children whose mothers smoked, and in children born to mothers with gestational diabetes. Further studies in other populations are needed to confirm our findings.

Conventionally grown fruits and vegetables (FVs) are the main source of general population exposure to pesticide residues.

To evaluate the relation of intake of high- and low-pesticide-residue FVs with cancer risk.

We followed 150,830 women (Nurses' Health Study, 1998-2016, and Nurses' Health Study II, 1999-2017) and 29,486 men (Health Professionals Follow-up Study, 1998-2016) without a history of cancer. We ascertained FV intake via validated food frequency questionnaires and categorized FVs as having high or low pesticide residue levels based on USDA surveillance data. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) of total and site-specific cancer related to quintiles of high- and low-pesticide-residue FV intake.

We documented 23,678 incident cancer cases during 2,862,118 person-years of follow-up. In the pooled multivariable analysis, neither high- nor low-pesticide-residue FV intake was associated with cancer. The HRs (95% CI) per 1 serving/day increase in intake were 0.99 (0.97-1.01) for high- and 1.01 (0.99-1.02) for low-pesticide-residue FVs. Additionally, we found no association between high-pesticide-residue FV intake and risk of specific sites, including malignancies previously linked to occupational pesticide exposure ([HR, 95% CI comparing extreme quintiles of intake] lung [1.17 (0.95-1.43)], non-Hodgkin lymphoma [0.89 (0.72-1.09)], prostate [1.31 (0.88-1.93)]) or inversely related to intake of organic foods (breasts [1.03 (0.94-1.31)]).

These findings suggest that overall exposure to pesticides through FV intake is not related to cancer risk, although they do not rule out associations with specific chemicals or sub-types of specific cancers.

These findings suggest that overall exposure to pesticides through FV intake is not related to cancer risk, although they do not rule out associations with specific chemicals or sub-types of specific cancers.Peatlands play a critical role in terrestrial carbon (C) storage, containing an estimated 30% of global soil C, despite occupying only 3% of global land area. Historic management of peatlands has led to widespread degradation and loss of important ecosystem services, including C sequestration. Legacy drainage features in the peatlands of northern Minnesota, USA were studied to assess the volume of peat and the amount of C lost in the ~100 years since drainage. Using high-resolution Light Detection and Ranging (LiDAR) data, we measured elevation changes adjacent to legacy ditches to model pre-ditch surface elevations, which were used to calculate peat volume loss. We established relationships between volume loss and site characteristics from existing geographic information systems datasets and used those relationships to scale volume loss to all mapped peatland ditches in northern Minnesota (USA). We estimated that 0.165 ± 0.009 km3 of peat have been lost along almost 4000 km of peatland ditches. Peat loss upslope of ditches was significantly less than downslope (P less then 0.001). Mean width of the entire ditch-effect zone was 333 ± 8.32 m. Using our volume loss estimates, literature estimates of oxidation, and mean bulk density and peat C% values from Minnesota peatlands, we calculate a total historic loss 3.847 ± 0.364 Tg C. Assuming a constant oxidation rate during the 100 years since drainage, euic and dysic peatlands within the ditch effect zone have lost 0.26 ± 0.08 and 0.40 ± 0.13 Mg C ha-1 yr-1, respectively, comparable to IPCC estimates. Our spatially-explicit peat loss estimates could be incorporated into decision support tools to inform management decisions regarding peatland C and other ecosystem services.Water shortage and quality deterioration are plaguing people all over the world. Providing sustainable and affordable treatment solutions to these problems is a need of the hour. Electrocoagulation (EC) technology is a burgeoning alternative for effective water treatment, which offers the virtues such as compact equipment, easy operation, and low sludge production. Compared to other water purification technologies, EC shows excellent removal efficacy for a wide range of contaminants in water and has great potential for addressing limitations of conventional water purification technologies. This review summarizes the latest development of principle, characteristics, and reactor design of EC. The design of key parameters including reactor shape, power supply type, current density, as well as electrode configuration is further elaborated. In particular, typical water treatment systems powered by renewable energy (solar photovoltaic and wind turbine systems) are proposed. Further, this review provides an overview on expanded application of EC in the removal of some newly concerned pollutants in recent years, including arsenite, perfluorinated compounds, pharmaceuticals, oil, bacteria, and viruses. The removal efficiency and mechanisms of these pollutants are also discussed. Finally, future research trend and focus are further recommended. This review can bridge the large knowledge gap for the EC application that is beneficial for environmental researchers and engineers.Biochar adsorbents can remove environmental pollutants and the remediation of Cr(VI) and nitrate are considered. Cr(VI) is a proven carcinogen causing serious health issues in humans and nitrate induced eutrophication causes negative effect on aquatic systems around the world. Douglas fir biochar (DFBC), synthesized by fast pyrolysis during syn gas production, was treated with aniline. Then, a polyaniline biochar (PANIBC) composite containing 47 wt% PANI was prepared by precipitating PANI on DFBC surfaces by oxidative chemical polymerization of aniline in 2M HCl. PANIBC exhibited a point of zero charge (PZC) of 3.0 and 8.2 m2/g BET (N2) surface area. This modified biochar was characterized by thermogravimetric analysis (TGA), scanning electron microscopy (SEM) morphology and surface elements, and oxidation states by X-ray photoelectron spectroscopy (XPS). PANIBC exhibited positive surface charge below pH 3, making it an outstanding adsorbent, for Cr(VI) removal. Cr(VI) and nitrate removal mechanisms are presented based on XPS analysis. DFBC and PANIBC Cr(VI) and nitrate adsorption data were fitted to Langmuir and Freundlich isotherm models with maximum Langmuir adsorption capacities of 150 mg/g and 72 mg/g, respectively. Cr(VI) and nitrate removal at pH 2 and 6 were evaluated by reducing the amount of PANI (9 wt%) dispersed on to DFBC. Adsorption capacities verses temperature studies revealed that both Cr(VI) and nitrate adsorption are endothermic and thermodynamically favored. Regeneration studies were conducted on both DFBC and PANIBC using 0.1M NaOH and PANIBC exhibited excellent sorption capacities for Cr(VI) and nitrate in lake water samples and in the presence of competitive ions.To mitigate the negative effects of land use developments, the current study focused on the hydrological connectivity within the landscape ecological network of Gharesou watershed, Iran, using Graph theory. Thus, scenarios of the future land use arrangements were used for the objective assessment of the effects of patterns on the ecological structures and functions, the main target being runoff control. Hydrological connectivity was analyzed using runoff source network, stream network and its buffer zone. Also, functions like permeability and runoff production potential were analyzed for the future scenarios. Following the ranking of the connectivity significance of the hydrological graphs elements, the ecosystem services hotspots and incompatible land uses were demonstrated. Subsequent assessments of the elements of runoff source networks using Circuit Theory helped identify the future critical areas. Analyses of the hydrological graphs and the runoff source network represented the amount and location of critical areas in each development scenario as well as the imposed hydrological costs.