Gregorymeyers4230

There is a call for integrative studies examining the roles of biological and psychosocial factors and their interrelations in shaping maternal postpartum psychopathology. Using longitudinal data from 198 primiparous mothers, we tested a biopsychosocial model for the etiology of maternal postpartum depressive symptoms that integrated childhood emotional maltreatment, couple relationship satisfaction, and oxytocin and dopamine D4 receptor genes (i.e., OXTR rs53576 and DRD4). Results indicate (a) two indirect effects from childhood emotional maltreatment and DRD4 to depressive symptoms at 1 year postpartum through couple relationship satisfaction at 6 months postpartum; (b) an interactive effect between DRD4 and couple relationship satisfaction at 6 months postpartum in predicting depressive symptoms at 1 year postpartum, which is in concert with the differential susceptibility hypotheses; and (c) no mediating effects or moderating effects (after adjusting for multiple testing with Bonferroni correction) involving OXTR rs53576. Notably, all associations were identified after controlling for several key covariates (e.g., maternal prenatal depressive symptoms). Last, robustness of the currently identified interactive effect involving DRD4 was demonstrated by an extensive set of additional analyses considering the effects of rGE, G × Covariates, and/or E × Covariates. Taken altogether, this study represents one of the initial efforts for a more sophisticated portrayal of how nature and nurture forces may work in conjunction with each other to shape new mothers' psychopathology. Yet given the current modest sample size and candidate gene approach, our findings are preliminary, should be cautiously interpreted, and need to be replicated with more rigorous designs. (PsycInfo Database Record (c) 2020 APA, all rights reserved).This research investigates the impact of parents' feelings of fulfillment and joy aroused by their infant and parenthood-referred to as child-related bliss-on their partnership satisfaction in the early period of parenthood between 6 and 24 months postpartum. In addition, the influence of partnership satisfaction during pregnancy and after childbirth on child-related bliss is investigated. Guided by family systems theory, we assumed both parents' child-related bliss to be positively associated with individual (i.e., spillover effects) as well as the spouse's partnership satisfaction (i.e., crossover effects). Longitudinal dyadic data from N = 135 heterosexual couples were analyzed using the actor-partner interdependence model, which takes interdependencies between couples into account. Taken as a set, the findings suggest that fathers' child-related and partnership-related perceptions are more closely linked than is the case for mothers. Fathers' child-related bliss 6 months postpartum positively influenced their partnership satisfaction at that time, and at 12 and 24 months postpartum. DNA Repair inhibitor For mothers, in contrast, such spillover effects were not detected. Most importantly with respect to interdependencies between couples, the results indicate crossover effects from fathers to mothers, that is, fathers' child-related bliss positively contributed to mothers' partnership satisfaction in the postnatal period. In contrast, mothers' bliss did not influence fathers' partnership satisfaction. The study demonstrates that fathers' parental feelings of fulfillment and bliss contribute to their individual and to mothers' partnership satisfaction. This highlights gender-specific couple dynamics, that is, an influence of fathers' blissful child-related feelings on mothers' partnership satisfaction in the postnatal period. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Unique pathways to adolescents' co-occurring internalizing/externalizing problems, a severe and common form of psychopathology, remain poorly delineated; this paucity of knowledge impedes the development of personalized interventions. We examined established measures of genetic risk and early childhood temperamental dimensions to clarify potentially distinct pathways to adolescents' co-occurring internalizing/externalizing problems. Participants were drawn from a longitudinal randomized controlled trial of a family-based intervention. The study employed multiple informants and methods, including observer ratings of toddlers' negative affectivity and behavioral inhibition, and primary caregiver ratings of toddlers' inhibitory control; internalizing and aggression polygenic risk scores (PRS) based on prior meta-genome-wide association studies (GWAS); and parents' and teachers' reports of adolescents' internalizing and externalizing problems. Higher levels of the aggression PRS indirectly predicted primary caregiver- and teacher-reported co-occurring problems relative to all other groups through greater early childhood negative affectivity. Lower levels of the aggression PRS and higher levels of the internalizing PRS indirectly predicted co-occurring problems relative to the externalizing "only" and low problem groups (primary caregivers only) through greater early childhood behavioral inhibition. Findings suggest two different genetic pathways to co-occurring problems that could lead to distinct prevention and intervention efforts. (PsycInfo Database Record (c) 2020 APA, all rights reserved).People with eating disorders (ED) have elevated rates of suicidal thoughts and behaviors. We used network analysis to identify symptoms that bridge EDs and suicidality, as well as central symptoms within the network, among 3 groups of adults. Participants were either (a) clinical psychiatric outpatients without current EDs (n = 538), (b) clinical psychiatric outpatients with a lifetime suicide attempt (n = 166), or (c) people with current EDs (n = 238). Networks were jointly estimated among groups. Within the Suicide Attempt and ED groups, interoceptive deficits and pain tolerance emerged as important bridge symptoms, whereas feeling inadequate was an important bridge symptom in the Clinical Outpatient group. Within all groups, having thoughts of killing oneself and feeling inadequate were central, meaning that they were most strongly connected to all other symptoms in the networks. Further, results indicate that a similar problem-interoceptive impairment-may link ED symptoms and suicidality both within people with EDs and people with suicide attempts.