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Aquifers in the Mojave and Whitewater River watersheds, located in the desert region, and the Los Angeles Basin, located on the coast, have been replenished with imported and treated water over the last half century to maintain sustainable groundwater levels. The recharge of imported water with different chemistries has altered the geochemical conditions in the aquifers, driving changes in fluoride concentrations.A novel strategy of sulfide modified zero valent iron (S-ZVI) coupled with the magnetic field (MF) is developed for selenite (Se(IV)) removal. The original ZVI particle size (30 μm), S/Fe ratio (180), solution pH (5), S-ZVI loading (0.75 g L-1), and MF intensity (20 mT) can exhibit the optimal enhancement effects of MF on Se(IV) removal by S-ZVI. Common corrosion promoters (Cl-, PO43-, SO42-, Mg2+, and Ca2+) and inhibitors (NO3-, SiO32-, and CO32-) show positive and negative effects on Se(IV) removal by S-ZVI, respectively. But MF can alleviate promoting or inhibiting effects of coexisting ions on Se(IV) removal by S-ZVI, and well preserve the reactivity of S-ZVI from background ions in water. Furthermore, MF can also enhance the reactivity of S-ZVI towards Se(IV) during consecutive experiments, the promotion factor (the ratio of kobs with MF to kobs without MF) increased from 2.57 to 5.83 with the increase of cycles. MF can not only improve the reactivity of ZVI covered with iron oxide or iron hydroxide but also effectively enhance the ability of ZVI covered with iron sulfide. S-ZVI exhibited good stability and recyclability in the presence of MF. XANES analysis of selenium species reveals that the reductive product of Se(IV) with or without MF is primarily Se(0), and Se(IV) removal by S-ZVI can be ascribed to adsorption and reduction. This work indicates that MF may widen the application of S-ZVI for pollutants removal in environmental remediation.The rapid growth of the express delivery industry resulted in the explosion of packaging waste with a wide range of direct and indirect environmental consequences. Until recently, little attention was given to this topic, but e-commerce and the associated growth of packaging waste exploded with the COVID-19 pandemic. Even though the phenomenon is only little to moderately documented, the waste problems in express delivery are recognized and caused by excessive packaging, lack of recyclability of the packaging material, and the low motivation of consumers to recycle. Key research, policy, and educational actions to reduce the environmental impacts of the fast-growing express delivery industry are discussed in this short discussion article.The Cape Fear River is an important source of drinking water in North Carolina, and many drinking water intakes in the watershed are affected by per- and polyfluoroalkyl substances (PFAS). We quantified PFAS concentrations and loads in river water upstream and downstream of a PFAS manufacturing plant that has been producing PFAS since 1980. River samples collected from September 2018 to February 2021 were analyzed for 13 PFAS at the upstream station and 43-57 PFAS downstream near Wilmington. Frequent PFAS sampling (daily to weekly) was conducted close to gauging stations (critical to load estimation), and near major drinking water intakes (relevant to human exposure). Perfluoroalkyl acids dominated upstream while fluoroethers associated with the plant made up about 47% on average of the detected PFAS downstream. Near Wilmington, Σ43PFAS concentration averaged 143 ng/L (range 40-377) and Σ43PFAS load averaged 3440 g/day (range 459-17,300), with 17-88% originating from the PFAS plant. LOADEST was a useful tool in quantifying individual and total quantified PFAS loads downstream, however, its use was limited at the upstream station where PFAS levels in the river were affected by variable inputs from a wastewater treatment plant. Long-term monitoring of PFAS concentrations is warranted, especially at the downstream station. Results suggest a slight downward trend in PFAS levels downstream, as indicated by a decrease in flow-weighted mean concentrations and the best-fitting LOADEST model. However, despite the cessation of PFAS process wastewater discharge from the plant in November 2017, and the phase-out of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in North America, both fluoroethers and legacy PFAS continue to reach the river in significant quantities, reflecting groundwater discharge to the river and other continuing inputs. Persistence of PFAS in surface water and drinking water supplies suggests that up to 1.5 million people in the Cape Fear watershed might be exposed.Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-I signaling is observed in the context of viral infections, autoimmunity (e.g., systemic lupus erythematosus), and type 1 interferonopathies, rare monogenic disorders characterized by constitutive activation of the IFN-I pathway. All these IFN-I-related disorders can cause renal dysfunction and share pathogenic and histopathological features. Collapsing glomerulopathy, a histopathological lesion characterized by podocyte loss, collapse of the vascular tuft, and parietal epithelial cell proliferation, is commonly associated with viral infections, has been described in type 1 interferonopathies such as Aicardi-Goutières syndrome and stimulator of IFN genes-associated vasculopathy with onset in infancy, and can also be induced by recombinant IFN therapy. DL-AP5 supplier In all these conditions, podocytes and parietal epithelial cells seem to be the primary target of IFN-I-mediated damage. Additionally, immune-mediated glomerular injury is common to viral infections, systemic lupus erythematosus, and type 1 interferonopathies such as coatomer subunit-α syndrome (COPA) and DNASE1L3 deficiency, diseases in which IFN-I apparently promotes immune-mediated kidney injury. Finally, kidney pathology primarily characterized by vascular lesions (e.g., thrombotic microangiopathy and vasculitis) is a hallmark of type 1 interferonopathy adenosine deaminase 2 deficiency as well as of systemic lupus erythematosus, viral infections, and IFN therapy. Defining the nosology, pathogenic mechanisms, and histopathological patterns of IFN-I-related kidney disorders has diagnostic and therapeutic implications, especially considering the likely near-term availability of novel drugs targeting the IFN-I pathway.MyD88 is a typical street protein of the TLRs signaling pathway and is a central player in innate immune signaling, which can regulate the NF-κB signaling pathway and promote downstream inflammatory factors. However, studies on the molecular mechanisms of the MyD88-mediated NF-κB signaling pathway in teleosts have been poorly reported. In this study, we report that Zw10 targets MyD88 to inhibit NF-κB activation. Zw10 inhibits cell proliferation and MyD88-mediated innate immunity in fish. Zw10 interacts with MyD88, and its Δ2 domain is very critical for MyD88 degradation. In addition, we found that Zw10 degrade MyD88 by autophagy, thereby negatively regulating the MyD88-mediated NF-κB signaling pathway. This study not only enriches the research on the innate immunity of teleost fish, but also provides insights for the regulating mechanism for mammals.Photoperiod and melatonin are important regulators of immunity. We hypothesized that these two factors play an important role in the regulation of immune responses in the Natrix piscator. Animals were kept in either short or long days and splenocyte immune responses were studied. Respiratory burst activity of splenocytes was assessed through reduction of nitrobluetetrazolium salt while production of nitric oxide was assessed indirectly by nitrite assay. Density gradient centrifugation was used to isolate splenic lymphocytes which were utilized to study proliferation with and without mitogens. Super oxide production by splenocytes was reduced significantly in the cultures obtained from animals kept either in short or long days. Nitrite release was decreased when animals were subjected to long days. The photoperiodic alterations acted differentially on proliferations of the splenic lymphocytes. Spontaneous and mitogen-induced proliferation of splenic lymphocytes were enhanced in cultures obtained from snakes maintained in short days when compared with cultures from snakes obtained either from long day or natural day length conditions. In vitro melatonin significantly enhanced the splenic lymphocyte proliferation of the cultures obtained from animals kept in long days when compared with splenic lymphocyte proliferations of the cultures obtained from long day animals or the animals kept in natural day length conditions. We found evidence which suggest that photoperiod may influence seasonal energy budgets and induce adjustments which optimize energy allocation for costly physiological processes such as immune function. In seasonally breeding animals such as Natrix piscator, the pineal hormone melatonin assists in the suppression of reproduction and elevation of immunity, which are the crucial adaptation for perpetuation of species.

The association of known cardiovascular risk factors and poor prognosis of coronavirus disease 2019 (COVID-19) has been recently emphasized. Coronary artery calcium (CAC) score is considered to be a risk predictor of cardiovascular events. Therefore, we have conducted a review of literature on the predictive value of CAC score predictive value in COVID-19 outcome.

A search of literature was conducted, aiming for articles published until December 2021 on PubMed and Scopus to identify potentially eligible studies.

A total of 18 articles were reviewed for association between higher CAC score and adverse outcomes in COVID-19.

The coronary calcium score could be considered as a new radiological marker for risk assessment in COVID-19 patients and providing additional information in fields of prognosis and possible cardiovascular complications. High CAC score is associated with higher in-hospital death and adverse clinical outcomes in patients with confirmed COVID-19, which highlights the importance of calcium load testing for hospitalized COVID-19 patients and calls for attention to patients with high CAC scores.

The coronary calcium score could be considered as a new radiological marker for risk assessment in COVID-19 patients and providing additional information in fields of prognosis and possible cardiovascular complications. High CAC score is associated with higher in-hospital death and adverse clinical outcomes in patients with confirmed COVID-19, which highlights the importance of calcium load testing for hospitalized COVID-19 patients and calls for attention to patients with high CAC scores.Climate change is leading to global sea level rise. Storm surges and higher tides will generate short-term 'pulses' of seawater into freshwater systems, often for the first time in over 3000 years. The effect of increased seawater inundation upon soil geochemistry is poorly understood. We identified 12 sites in South Australia which are predicted to be inundated by seawater storm surges in the next 20 years. Within these 12 sites are three distinct environments; fresh water streams and lakes, hypersaline saltmarsh and mangroves, and acid sulfate soils. Soils were inundated with seawater under laboratory conditions to replicate a short-term (two weeks) inundation by a storm surge. Lowering of redox potential and dissolution of high concentrations of reactive Mn and Fe in freshwater environments lead to the release of dissolved Fe and Mn in the soils from freshwater environments. Soils also released As, Cu, Ni, Cd and Co, while Zn and Pb were less mobilised. Concentrations of metals released exceeded water quality guidelines to protect freshwater aquatic ecosystems in most cases.