Larkinbowman5444

Central precocious puberty (CPP) severely affects children's physical and mental health and needs to be treated promptly and effectively. This article aimed to research the therapeutic effect of Shugan Xiehuo Formula (SXF) on CPP. A female CPP rat model was established and then treated with leuprolide and different doses of SXF. Sex organ volume and index were measured. Ovaries and uteri were visualized by hematoxylin-eosin staining. The concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and estradiol (E2) in peripheral blood were determined. The expression levels of gonadotropin-releasing hormone (GnRH), gonadotropin-releasing hormone receptor (GnRHR), estrogen receptor alpha (ERα), and G protein-coupled receptor 30 (GPR30) in the hypophysis were investigated by Real-Time Quantitative Reverse Transcription PCR and western blot. GnRH expression in the hypothalamus and GnRHR expression in the ovary were detected by immunohistochemistry. SXF reduced the volume of the bilateral ovaries, as well as the volumes of the uterus, hypothalamus, and hypophysis in the female CPP rats and diminished the index of the ovary, uterus, hypothalamus, and hypophysis in the female CPP rats (P less then 0.05 or P less then 0.01). Enasidenib concentration SXF treatment inhibited follicle maturation and uterine wall thickening in the female CPP rats. SXF decreased the concentrations of FSH, LH, PRL, and E2 in the peripheral blood in the female CPP rats (P less then 0.01 or P less then 0.001). SXF suppressed the expressions of GnRH, GnRHR, ERα, and GPR30 in the hypophysis (P less then 0.05), the expression of GnRH in the hypothalamus (P less then 0.01), and the expression of GnRHR in the ovaries (P less then 0.001) of the female CPP rats. Overall, our study revealed that SXF had therapeutic effects on CPP in female rats. This is worthy of promoting clinically.We systematically retrieved and summarised clinical studies on traditional Chinese medicine (TCM) for the prevention and treatment of essential hypertension (EH) using the evidence map. We aimed to explore the evidence distribution, identify gaps in evidence, and inform on future research priorities. Clinical studies, systematic reviews, guidelines, and pathway studies related to TCM for the prevention and treatment of EH, published between January 2000 and December 2019, were included from databases CNKI, WanFang Data, VIP, PubMed, Embase, and Web of Science. The distribution of evidence was analysed using text descriptions, tables, and graphs. A total of 9,403 articles were included, including 5,920 randomised controlled studies (RCTs), 16 guidelines, expert consensus and path studies, and 139 systematic reviews (SRs). The articles publishing trend increased over time. This study showed that the intervention time of TCM was concentrated at 4-8 weeks, mainly through Chinese herbal medicine (CHM) for the prevention and treatment of elderly hypertension and the complications. A Measurement Tool to Assess Systematic Reviews (AMSTAR) scores of the included reviews ranged from 2 to 10. Most of the SRs had a potentially positive effect (n = 120), mainly in 5-8 score. Primary studies and SRs show potential benefits of TCM in lowering blood pressure, lowering the TCM syndrome and symptom differentiation scores (TCM-SSD scores), improving the total effective rate, and reducing the adverse events. The adjunctive effect of TCM on improving the total effective rate, lowering the blood pressure, lowering the TCM-SSD scores, and lowering the adverse effects was only supported by low-quality evidence in this research. The evidence map was used to show the overall research on TCM for the treatment of EH; however, due to the existing problems of the primary studies, the current research conclusion needs further research with higher quality and standardisation.

This study aims to translate the Rochester Participatory Decision-Making Scale (RPAD) into the Chinese language and to test the reliability and validity of the Chinese version of the scale in the gynecological clinic.

After obtaining the permission of the original author, the Brislin translation model was used to forward-translation and back-translation. Then, an expert group was set up to discuss this scale and result in cross-cultural adaptation. A convenient sampling method was used to select ten doctors working in the gynecological clinic of two top-three hospitals and 20 patients of each doctor. The Rochester Decision Participation Scale was used by the Chinese version for investigation.

The Chinese version of the Rochester Participatory Decision-Making Scale has a Cronbach's

coefficient of 0.604 for the total content reliability, the Spearman-Brown coefficient of half-reliability is 0.646, and the Guttman coefficient of half-reliability is 0.612. The retest reliability is 0.922. By exploratory factor analysis, the scale extracted three common factors, and the standard factor load corresponding to each entry is higher than 0.4.

The reliability and validity of the Chinese version in the Rochester Participatory Decision-Making Scale are acceptable, which can be used to evaluate doctors "promotion of patients" participation in decision-making.

The reliability and validity of the Chinese version in the Rochester Participatory Decision-Making Scale are acceptable, which can be used to evaluate doctors "promotion of patients" participation in decision-making.

Traditional Chinese medicine (TCM) for the treatment of female infertility remains ambiguous. The aim of the present case-control study was to examine the association between TCM treatment and successful pregnancy among infertile women.

This population-based case-control study included the data from 2,627 infertile women with successful pregnancy and 2,627 infertile women without successful pregnancy using datasets from the Longitudinal Health Insurance Database 2000 of the National Health Insurance Research Database during 2000-2010. The odds ratios (ORs) and 95% confidence intervals (CIs) for the relationship between TCM use and successful pregnancy in infertility women were estimated using logistic regression.

Patients who received TCM treatment significantly increased in successful pregnancy (OR = 1.48; 95% CI = 1.31-1.66), compared with patients without TCM. Si-Wu-Tang (OR = 4.25; 95% CI = 2.18, 8.30), Gui-Zhi-Fu-Ling-Wan (OR = 3.27; 95% CI = 2.13, 5.02), and Jia-Wei-Xiao-Yao-San (OR = 3.17; 95% CI = 2.