Foleydelgado5667

Polyphenolic molecules have become attractive building blocks for bioinspired materials due to their adhesive characteristics, capacity to complex ions, redox chemistry, and biocompatibility. For the formation of tannic acid (TA) surface modifications based on silicate-phenolic networks, a high ionic strength is required. In this study, we investigated the effects of NaCl, KCl, and LiCl on the formation of TA coatings and compared it to the coating formation of pyrogallol (PG) using a quartz-crystal microbalance. We found that the substitution of NaCl with KCl inhibited the TA coating formation through the high affinity of K+ to phenolic groups resulting in complexation of TA. Assessment of the radical formation of TA by electron paramagnetic resonance spectroscopy showed that LiCl resulted in hydrolysis of TA forming gallic acid radicals. Further, we found evidence for interactions of LiCl with the Siaq crosslinker. In contrast, the coating formation of PG was only little affected by the substitution of NaCl with LiCl or KCl. Our results demonstrate the interaction potential between alkali metal salts and phenolic compounds and highlight their importance in the continuous deposition of silicate-phenolic networks. These findings can be taken as guidance for future biomedical applications of silicate-phenolic networks involving monovalent ions.Covellite-phase CuS and carrollite-phase CuCo2S4 nano- and microstructures were synthesized from tetrachloridometallate-based ionic liquid precursors using a novel, facile, and highly controllable hot-injection synthesis strategy. The synthesis parameters including reaction time and temperature were first optimized to produce CuS with a well-controlled and unique morphology, providing the best electrocatalytic activity toward the oxygen evolution reaction (OER). In an extension to this approach, the electrocatalytic activity was further improved by incorporating Co into the CuS synthesis method to yield CuCo2S4 microflowers. Both routes provide high microflower yields of >80 wt %. The CuCo2S4 microflowers exhibit a superior performance for the OER in alkaline medium compared to CuS. This is demonstrated by a lower onset potential (∼1.45 V vs RHE @10 mA/cm2), better durability, and higher turnover frequencies compared to bare CuS flowers or commercial Pt/C and IrO2 electrodes. Likely, this effect is associated with the presence of Co3+ sites on which a better adsorption of reactive species formed during the OER (e.g., OH, O, OOH, etc.) can be achieved, thus reducing the OER charge-transfer resistance, as indicated by X-ray photoelectron spectroscopy and electrochemical impedance spectroscopy measurements.Understanding the interactions between nanomaterials and biological systems plays a pivotal role in enhancing the efficacy of nanomedicine and advancing the disease diagnosis. The nanoparticle-protein corona, an active biomolecular layer, is formed around nanoparticles (NPs) upon mixing with biological fluid. SY-5609 concentration The surface layer which consists of rapidly exchanged biomolecules is called the "soft" corona. The inner layer which is more stable and tightly packed is called the "hard" corona. It has been suggested that the NP-protein corona has a decisive effect on the in vivo fate of nanomedicine upon intravenously administration into the mouse. Furthermore, the features of the NP-protein corona make it a powerful platform to enrich low-abundance proteins from serum/plasma for downstream mass-spectrometry (MS)-based proteomics for biomarker discovery and disease diagnosis.Herein, we summarize our recent work on the development of nanomedicine and disease detection from the level of nano-bio interactions between naical fate of NPs, whereas it opens a new avenue to enrich low abundant proteins in a biospecimen ex vivo to render them "visible" for downstream analytical workflows, such as MS-based proteomics. Blood serum/plasma, due to easy accessibility and great potential to uncover and monitor physiological and pathological changes in health and disease, has remained a major source of detecting protein biomarker candidates. Inspired by the features of the NP-protein corona, a Proteograph platform, which integrates multi-NP-protein coronas with MS for large-scale efficient and deep proteome profiling has been developed. Finally, we conclude this Account with a better understanding of nano-bio interactions to accelerate the nanomedicine translation and how MS-based proteomics can boost our understanding of the corona composition and facilitate the identification of disease biomarkers.The fundamental challenge for enhancing the thermoelectric performance of n-type PbTe to match p-type counterparts is to eliminate the Pb vacancy and reduce the lattice thermal conductivity. The Cu atom has shown the ability to fill the cationic vacancy, triggering improved mobility. However, the relatively higher solubility of Cu2Te limits the interface density in the n-type PbTe matrix, leading to a higher lattice thermal conductivity. In particular, a quantitative relationship between the precipitate scattering and the reduction of lattice thermal conductivity in the n-type PbTe with low solubility of Cu2Te alloys still remains unclear. In this work, trivalent Sb atoms are introduced, aiming at decreasing the solubility of Cu in PbTe for improving the precipitate volumetric density and ensuring n-type degenerate conduction. Benefiting from the multiscale hierarchical microstructures by Sb and Cu codoping, the lattice thermal conductivity is considerably decreased to 0.38 W m-1 K-1. The Debye-Callaway model quantifies the contribution from point defects and nano/microscale precipitates. Moreover, the mobility increases from 228 to 948 cm2 V-1 s-1 because of the elimination of cationic vacancies. Consequently, a high quality factor is obtained, enabling a superior peak figure of merit ZT of ∼1.32 in n-type Pb0.975Sb0.025Te by alloying with only ∼1.2% Cu2Te. The present finding demonstrates the significant role of low-solubility Cu2Te in advancing thermoelectrics in n-type PbTe.Van der Waals (vdWs) heterostructures based on in-plane isotropic/anisotropic 2D-layered semiconducting materials have recently received wide attention because of their unique interlayer coupling properties and hold a bright future as building blocks for advanced photodetectors. However, a fundamental understanding of charge behavior inside this kind of heterostructure in the photoexcited state remains elusive. In this work, we carry out a systematic investigation into the photoinduced interfacial charge behavior in type-II WS2/ReS2 vertical heterostructures via polarization-dependent pump-probe microscopy. Benefiting from the distinctive (ultrafast and anisotropic) charge-transfer mechanisms, the photodetector based on the WS2/ReS2 heterojunction displays more superior optoelectronic properties compared to its constituents with diverse functionalities including moderate photoresponsivity, polarization sensitivity, and fast photoresponse speed. Additionally, this device can function as a self-driven photodetector without the external bias.