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Distance or remote cognitive assessments, administered via phone or computer platforms, have emerged as possible alternatives to traditional assessments performed during office visits. Distance refers to any nontraditional assessment feature, not only or necessarily location. We conducted a systematic review to examine the psychometric soundness of these approaches.

We searched PubMed, PsycINFO, AgeLine, and Academic Search Premier for articles published between January 2008 and June 2020. Studies were included if participants were over the age of 50, a structured assessment of cognitive function in older adults was evaluated, the assessment method was deemed distant, and validity and/or reliability data were reported. Assessment distance was defined as having any of the following features use of an electronic test interface, nonroutine test location (e.g., home), test self-administered, and test unsupervised. Distance was categorized as low, intermediate, or high.

Twenty-six studies met inclusion criteve assessments with older adults appears supported at lower but not higher distance. Less is known about the reliability of such assessments. Future research should delineate the person and procedure boundaries for valid and reliable test results.

This pilot study was designed to determine if adolescents had mastered the grammar of past tense counterfactual (PTCF) sentences (e.g., "If Julie had done all of the track workouts, she might have won the state meet"). https://www.selleckchem.com/products/me-401.html Of interest was their ability to use the modal, auxiliary, and past participle verbs correctly in the main clause of a PTCF sentence. Prior research had indicated that PTCF sentences were challenging to older children. Hence, we wished to determine if PTCF sentences would continue to challenge adolescents.

The participants were two groups of adolescents, who were aged 13 and 16 years, and a control group of young adults having a mean age of 22 years (n = 40 per group). Each participant read a set of four fables and completed a PTCF sentence based on the story. Each incomplete sentence contained a subordinate clause that employed the past perfect verb form (e.g., "If the fox had been able to jump higher…"). The participant's task was to complete the sentence in writing, generating a grammatiical mastery and for the distinction between prescriptive and descriptive grammar.Backgroup Short sleep duration potentially affects the risk of developing asthma and asthmatic exacerbation. Our aim is to determine the associations between sleep duration with asthmatic phenotypes, FeNO, blood eosinophils, and lung function among current asthmatics.

558 individuals from National Health and Nutrition Examination Survey (NHANES) during 2007-2012 were included into this study. Self-report sleep duration was divided into three groups short (≤ 6 h), healthy (7h to 8h) and long (≥ 9 h). By using multivariate generalize additive model with binomial or Poisson regression, the abovementioned associations were evaluated after adjustment for potential confounders.

Our study population included 284 short sleepers, 240 healthy sleepers and 34 long sleepers, respectively. In multivariate binomial regression analysis, we found that short sleep duration was associated with increased risk of asthma with central obesity (adjusted OR = 0.58, 95%CI 0.33 - 0.99, P = 0.047) compared with healthy sleep duratioth a significant reduction of FeNO and increase of blood eosinophils percentage.Surface-enhanced Raman scattering (SERS) has drawn attention for broad applications. We successfully fabricated highly effective SERS structures via evaporation-induced self-assembly of blend nanoparticles containing sliver nanospheres (Ag NSs) and gold nanorods (Au NRs) on a super-hydrophobic (SH) substrate. On the SH substrate, the droplets of the mixed aqueous solution of silver nanospheres (Ag NSs), gold nanorods (Au NRs), and probe molecules can preserve their spherical shape during the evaporation process, and the probe molecules (R6G) are confined into extremely small areas after solvent removal due to hydrophobicity-enhanced concentration effects. The Raman enhancement effect of the blend nanoparticles with 40 vol% Ag NSs is far higher than that of the other samples. The structure of the aggregated Ag NSs on the film-like Au NRs greatly enhances the SERS effect of Ag NSs, which is optimal for the blend system with 40 vol% Ag NSs. The SERS structure also displays excellent signal reproducibility (RSD less then 10%) and low detection limits (0.5 nM). Thus, this work offers a simple and efficient strategy to fabricate a highly effective SERS structure with broad applications in environmental science, analytical chemistry, etc.

Electrical preferential activation of small nociceptive fibers may be achieved with the use of specialized small area electrodes, however, the existing electrodes are limited to low stimulation intensities. As existing electrodes have been developed empirically, the present study aimed to use computational modeling and optimization techniques to investigate if changes in electrode design parameters could improve the preferential activation of small fibers.

Two finite element models; one of a planar concentric and one of an intra-epidermal electrode were combined with two multi-compartmental nerve fiber models of an Aδ-fiber and an Aβ-fiber. These two-step hybrid models were used for the optimization of four electrode parameters; anode area, anode-cathode distance, cathode area, and cathode protrusion. Optimization was performed using a gradient-free bounded Nelder-Mead algorithm, to maximize the current activation threshold ratio between the Aβ-fiber model and the Aδ-fiber model.

All electrode parameterotentially be used for clinical assessment of small fiber neuropathy.

The present study showed that electrical preferential small fiber activation can be improved by electrode design. Additionally, the results may be used for the production of an electrode that could potentially be used for clinical assessment of small fiber neuropathy.Osteochondral (OC) matrix design poses a significant engineering challenge due to the complexity involved with bone-cartilage interfaces. To better facilitate the regeneration of OC tissue, we developed and evaluated a biodegradable matrix with uniquely arranged bone and cartilage supporting phases a poly(lactic-co-glycolic) acid (PLGA) template structure with a porosity gradient along its longitudinal axis uniquely integrated with hyaluronic acid hydrogel. Micro-CT scanning and imaging confirmed the formation of an inverse gradient matrix. Hydroxyapatite was added to the PLGA template which was then plasma-treated to increase hydrophilicity and growth factor affinity. An osteogenic growth factor (bone morphogenetic protein 2; BMP-2) was loaded onto the template scaffold via adsorption, while a chondrogenic growth factor (transforming growth factor beta 1; TGF-β1) was incorporated into the hydrogel phase. Confocal microscopy of the growth factor loaded matrix confirmed the spatial distribution of the two growth factors, with chondrogenic factor confined to the cartilaginous portion and osteogenic factor present throughout the scaffold. We observed spatial differentiation of human mesenchymal stem cells (hMSCs) into cartilage and bone cells in the scaffolds in vitro cartilaginous regions were marked by increased glycosaminoglycan production, and osteogenesis was seen throughout the graft by alizarin red staining. In a dose-dependent study of BMP-2, hMSC pellet cultures with TGF-β1 and BMP-2 showed synergistic effects on chondrogenesis. These results indicate that development of an inverse gradient matrix can spatially distribute two different growth factors to facilitate chondrogenesis and osteogenesis along different portions of a scaffold, which are key steps needed for formation of an osteochondral interface.Direct medications of salmon calcitonin (sCT) through subcutaneous or intramuscular injection are limited for its low effeciency. Drug delivery systems with sustained delivery property and high bioactivity are imminently needed. In consideration of the clinic application, a cost-effective and effective carrier is demanded, which is still a challenge until now. In this study, a simple alginate/ alginate sulfate-sCT (Alg/AlgS-sCT) complex was succesfully constructed for sustained release of sCT. The negtively charged sulphate groups facilitate the bonding with sCT, which avoids the burst release of sCT and extends the release time up to 15 days (only 2 days for pure sCT). More importantly, the bioactivity of the released sCT is not affected during such long release time, suggesting a conformation similar to native sCT. In vitro analysis implies the biocompatibility of the complex. Moreover, the combination of AlgS and sCT synergistically impoved the osteogenic ability of MC3T3 cells, showing higher ALP level, intracellular and extracellular calcium ions concentrations. Note that the concentration of intracellular calcium ions displays 5.26 fold increments of control group after 10 days of incubation. We envision this simple yet effective system has potential applications in clinical trails and give inspiration for the design of other protein delivery system.Poly(3,4-ethylenedioxythiophene)poly(styrenesulfonate) (PEDOTPSS) is a practical conducting polymer. The gel-film formation process produces a PEDOTPSS organogel with a structure between a PEDOTPSS water dispersion and a dried film. We found that this film has a high water-swelling ratio and thickens by a hitherto unreported factor of approximately 6600% as its swells to form a hydrogel. In this study, we investigated the drying behaviour of a hydrogel and an organogel with electrical properties to elucidate the internal structures of the gel responsible for the swelling and shrinkage behaviour with high expansion and contraction ratios. SEM revealed that the gel is composed of a 3D fibrillar network consisting of fibrils that are 4.6 ± 1.6 μm long and 0.63 ± 0.29 μm in diameter. This network plays a pivotal role in the conduction of electricity and swelling behaviour with high expansion ratios. The thickness of the gel decreased to 1/66 of its original value after drying on a substrate, while the total electrical resistance decreased by only 20%. The organogel exhibited the same drying behaviour as the hydrogel, which indicates that the network forms first in the organogel and is maintained in the subsequent swelling and drying processes. The electrical conductivity of the hydrogel increased from 9.0 ± 0.1 to 346.4 ± 1.2 S cm-1 under anisotropic shrinking from 3.1 ± 0.2 mm to 77.4 ± 3.3 μm. The network plays an important role as an enhanced swelling framework by providing effective pathways for the conduction of electricity.Li-O2 batteries (LOB) are considered as one of the most promising energy storage devices using renewable electricity to power electric vehicles because of its exceptionally high energy density. Carbon materials have been widely employed in LOB for its light weight and facile availability. In particular, graphene is a suitable candidate due to its unique two-dimensional structure, high conductivities, large specific surface areas, and good stability at high charge potential. However, the intrinsic catalytic activity of graphene is insufficient for the sluggish kinetics of oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in LOB. Therefore, various surface functionalization schemes for graphene have been developed to tailor the surface chemistry of graphene. In this review, the properties and performances of functionalized graphene cathodes are discussed from theoretical and experimental aspects, including heteroatomic doping, oxygen functional group modifications, and catalyst decoration. Heteroatomic doping breaks electric neutrality of sp2 carbon of graphene, which forms electron-deficient or electron-rich sites.