Ebbesendobson0913

Conclusions There is no association of T-397C polymorphic variant of estrogen receptor gene ESR1 with the development of premenstrual syndrome.

Conclusions There is no association of T-397C polymorphic variant of estrogen receptor gene ESR1 with the development of premenstrual syndrome.

The aim of the work was to develop and apply in the clinical trial a software product for the dental caries prediction based on neural network programming.

Materials and methods Dental examination of 73 persons aged 6-7, 12-15 and 35-44 years was carried out. The data obtained during the survey were used as input for the construction and training of the neural network. The output index was determined by the increase in the intensity of caries, taking into account the number of cavities. To build a neural network, a high-level Python programming language with the NumPay extension was used.

Results The intensity of carious dental lesions was the highest in 35-44 years old patients - 6.69 ± 0.38, in 6-7 years old children and 12-15 years old children it was 3.85 ± 0.27 and 2.15 ± 0.24, respectively (p <0.05). After constructing and training the neural network, 61 true and 12 false predictions were obtained based on these indices, the accuracy of predicting the occurrence of caries was 83.56%. Based on these results, a graphical user interface for the "CariesPro" software application was created.

Conclusions The resulting neural network and the software product based on it permit to predict the development of dental caries in persons of all ages with a probability of 83.56%.

Conclusions The resulting neural network and the software product based on it permit to predict the development of dental caries in persons of all ages with a probability of 83.56%.

The aim The aim of the research was to study the prevalence of visceral and phenotypic markers of UCTD syndrome in patients with GERD for the purpose of early diagnosis of this comorbidity.

Materials and methods The study included 120 patients 75 patients (Group II) - GERD was on the background of UCTD, 45 (Group I ) - the patients with GERD. The average age of the patients was 42.05 ± 6.5 years. Evaluations of UCTD's were performed accordingly to the criteria recommended by M. Moska et al., A. Doria et al., T. I. Kadurina, L. M. Abbakumova in the modification of T. Milkovskaya-Dimitrova, and the degree of their expression on the scale of T. Y. Smolnova.

Results Among the examined patients, the specific criteria for the certain connective tissue diseases were detected in the patients with UCTD from 2.7 and 20.0% more often. Bone, joint and skin phenotypic signs of dysplasia were observed in patients with GERD associated with UCTD by 4-4.5 times more often. Various abnormalities of internal organs develoained data indicated that the number of pathological GER was significantly higher in the setting of comorbidity. Our research also showed that the chances of diagnosing Reynaud's Syndrome, arthralgia, unmotivated body weight loss, dysphagia, skin rash, oral ulcers, proximal muscle weakness in the patients with GERD associated with UCTD are higher in comparison with the patients with GERD without comorbidity (р less then 0.05). This should necessarily be taken into account in the early diagnosis and when assigning a complex therapy in case of this pathology.

The aim Determine the frequency of surgery-appendectomy of patients with chronic non-atrophic gastritis and the impact of this transaction on the pathogenesis of chronic gastritis.

Materials and methods Data of disease history and life were analyses, as well as the results of a comprehensive survey of 245 patients with chronic non-atrophic gastritis. Comprehensive examination included step-by-step рН-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous.

Results Helicobacter infection was detected in 100% of cases. It was found that 56 (22.9%) of patients were subjected to appendectomy. Age of patients, who had an appendectomy ranged from 4 to 40 years and averaged 18.34 ± 1.05 years, and the first pathological manifestations of the gastro-intestinal tract appeared in an average of 28.27± 1.75 year, i.e. in 10 years. As for the age qualification pupil were the earliest pathological manifestations appeared in a group of patients from 11 to 15 years (13 people (23.2%) and amounted to about 6 years after the operation, and 6 (46.2%) patients, manifestations appeared in 2-6 months after surgery; the most recent is in group from 16 to 20 years (19 people (33.9%) and amounted to about 14 years (p < 0.05).

Conclusions Surgery on the body of immune system - appendix provokes activation of latent form of chronic non-atrophic gastritis, especially during puberty.

Conclusions Surgery on the body of immune system - appendix provokes activation of latent form of chronic non-atrophic gastritis, especially during puberty.

The aim of the work was to study the antiviral activity of the metabolites of the probiotic strain Lactobacillus rhamnosus GG (LGG or ATCC 53103) regarding clinical strains of enteroviruses (Coxsackie B-5, ECNO21) isolated from the feces of intestinal infections.

Materials and methods The object of the study was substrate-dependent cell cultures of HeLa, Vero, Hep-2 lines. The titer of the virus was determined by the presence of a clear cytopathic action (CPA) in the monolayer infected cells of the virus.

Results Determination of the enteric virus infections activity in the culture fluid showed that in samples with the LGG metabolites, the infections activity of the clinical strains of enteroviruses decreased after 24 hours, at 1.5-1.7 (p <0.05) times, and after 96 hours in 3, 6 - 5,7 times (p <0,01). the processing of cell cultures by metabolites in the amount of 0.3 mg / ml contributed to a decrease in the titer of viruses by 2.77 ± 0.11 lg TCDD50 / cm3, 2.83 ± 0.11 lg TCD50 / cm3 and 2.94 ± 0.13 lg TCD50 / cm3 for Vero, HeLa and Hep-2 line cells in 24 hours.

Conclusions It has been experimentally determined that the maximum tolerated dose (MTD) of L. rhamnosus GG metabolites was 0.3 μg / ml for all cultures of cell lines. Determination of the antiviral activity of L. rhamnosus GG metabolites in clinical viruses of enteroviruses (Coxsackie B-5 and ECNO-21) showed a decrease in infection activity in 1.5-1.7 times, (p <0.05) of clinical trials in clinical trials enteroviruses.

Conclusions It has been experimentally determined that the maximum tolerated dose (MTD) of L. Nicotinamide Riboside research buy rhamnosus GG metabolites was 0.3 μg / ml for all cultures of cell lines. Determination of the antiviral activity of L. rhamnosus GG metabolites in clinical viruses of enteroviruses (Coxsackie B-5 and ECNO-21) showed a decrease in infection activity in 1.5-1.7 times, (p less then 0.05) of clinical trials in clinical trials enteroviruses.