Guptamccullough7320

High mobility group box 1 (HMGB1) and homocysteine (Hcy) play important roles in contrast-induced acute kidney injury (CI-AKI). We compared HMGB1 to Hcy as preprocedural predictors for CI-AKI in coronary artery disease (CAD) patients after percutaneous coronary artery intervention (PCI).

We included 257 eligible patients who were categorized into CI-AKI ( +) and CI-AKI ( -) group. The differences in clinical characteristics and biochemical indexes between two groups were analyzed.

We observed that thirty-eight (14.8%) of 257 eligible CAD patients developed CI-AKI. HMGB1 (14.65 [11.13-24.89] vs 10.88 [7.94-13.23], p < 0.001) and Hcy (14.07 [12.07-17.31] vs 12.09 [10.71-13.47], p < 0.001) increased significantly in CI-AKI ( +) group. Both age (r = 0.210, p = 0.001), serum creatinine (r = 0.509, p < 0.001), eGFR (r =  - 0.459, p < 0.001) and Hcy (r = 0.531, p < 0.001) were significantly correlated with HMGB1. Among all patients, HMGB1 (OR 1.181, 95% CI 1.081-1.290, p < 0.001) and Hcy (OR 1.260, 95% CI 1.066-1.489, p = 0.007) were independent predictors for the development of CI-AKI. We built the propensity score matching (PSM) using 38 pairs of patients. After adjustment, HMGB1 (OR 1.169, 95% CI 1.035-1.322, p = 0.012) and Hcy (OR 1.457, 95% CI 1.064-1.997, p = 0.019) were also independent predictors for the development of CI-AKI. Both HMGB1 (AUC 0.704, 95% CI 0.588-0.819, p = 0.002) and Hcy (AUC 0.708, 95% CI 0.593-0.823, p = 0.002) had predictive values for CI-AKI.

There is a significant positive association between HMGB1 and Hcy in CAD patients. Both HMGB1 and Hcy are potential preprocedural predictors of CI-AKI after PCI.

There is a significant positive association between HMGB1 and Hcy in CAD patients. Both HMGB1 and Hcy are potential preprocedural predictors of CI-AKI after PCI.

We investigated the prognostic accuracy of scores of SOFA for 90-day mortality in patients with kidney transplant status identified from the public Medical Information Mart for Intensive Care III databank.

A total of 428 participants with kidney transplant status who were admitted for the first time to the ICU were included. The target-independent and target-dependent variables were the SOFA scores in the first 3 days of ICU admission and 90-day mortality, respectively.

Fully adjusted binary logistic regression indicated that the day-2 and day-3 SOFA scores were positively associated with a risk of 90-day mortality after adjustment for confounders (odds ratio 1.196, 95% confidence interval 1.052-1.360; odds ratio 1.233, 95% confidence interval 1.062-1.432). The receiver operating characteristic curve showed areas under the curve for the prediction of 90-day mortality from SOFA scores on days 1, 2and 3 were 0.524, 0.654, and 0.727, respectively. Further analysis using Kaplan-Meier survival curves and multivariate regression models of 90-day survival showed that patients with low SOFA scores survived longer than those with high scores.

The SOFA scores in the early days of ICU admission were positively associated with 90-day outcomes although the first-day score showed no significant correlation.

The SOFA scores in the early days of ICU admission were positively associated with 90-day outcomes although the first-day score showed no significant correlation.The efficacy of slow-release formulations of tribenuron-methyl (TBM) embedded in the matrix of degradable poly(3-hydroxybutyrate) blended with birch wood flour [polymer/wood flour/herbicide 50/30/20 wt.%] was compared with the efficacy of TBM as the active ingredient of the Mortira commercial formulation, which was applied as post-emergence spray to treat spring wheat cv. Novosibirskaya 15. The study was conducted in Central Siberia (in the environs of the city of Krasnoyarsk, Russia) from May to August 2020. The biological efficacy of the embedded TBM was 92.3%, which was considerably higher than the biological efficacy of the Mortira formulation used as the post-emergence spray (15.4%). The embedding of TBM into degradable blended matrix enabled long-duration functioning of this unstable herbicide in soil. The sensitivity of weed plants to TBM differed depending on the species. TBM was more effective against A. retroflexus and A. blitoides, which were killed at an earlier stage, than against C. album and G. aparine, whose percentage increased in the earlier stage and which were controlled by the herbicide less effectively and at later stages. On the plot treated with the embedded herbicide, the parameters of the wheat yield structure were the best, and the total yield was the highest 3360 ± 40 kg/ha versus 3250 ± 50 kg/ha in the group of plants sprayed with the Mortira formulation. The grain produced in all groups was of high quality and was classified as Grade 1 food grain. The highest quality parameters (grain hectoliter mass, gluten, and protein contents) were obtained in the group of plants treated with the embedded herbicide. The study of the embedded TBM confirmed the high efficacy of the experimental formulation.An investigative biomonitoring study was conducted along the coastal area of Laizhou Bay (China) to evaluate the impact of organic pollution on the clam Ruditapes philippinarum using bioaccumulation and multi-biomarker measurements. In addition, the polychlorinated biphenyls (PCBs), total petroleum hydrocarbons (TPHs) and nonylphenol (NP) content in surface sediment at the study sites were also analyzed. Concentrations of PCBs, TPHs and NP in the sediments of the study area were 1.90 ± 0.10 μg kg-1, 39.55 ± 2.42 mg kg-1, 9.23 ± 0.41 μg kg-1 dry weight, respectively, while the organic contaminants in the soft tissues of R. philippinarum were 14.81 ± 0.96 μg kg-1 for PCBs, 165.87 ± 5.03 mg kg-1 for TPHs and 86.16 ± 5.29 μg kg-1 for NP. Linear regression analysis on the levels of organic pollutants accumulated in R. philippinarum and in sediments showed no significant correlation. Multi-biomarkers including superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, total glutathione and lipid peroxidation were assayed in gills and digestive glands of R. philippinarum. Finally, the biomarkers in gills were selected to calculate the Integrated Biomarker Response (IBR) index and to evaluate the impact of the three organic contaminants on R. philippinarum collected from different sites. According to IBR results, the western coast and eastern coast exhibited higher environmental stress than the sampling sites along the southern coast of Laizhou Bay. Significant correlation was found between the level of organic contaminants in the sediments and IBR whereas no dependence was found between pollutants' concentrations in sediments and separate biomarker responses. The results showed that PCBs and NP were the main organic pollutants among the three studied which have caused pollution pressure on R. philippinarum in Laizhou Bay coastal area.The identification of pollutant source release history in rivers is important for emergency response of pollution accidents and formulating remediation strategies. Space-time radial basis collocation method (RBCM), as a meshless method with strong applicability, can directly estimate the release history from the concentration data measured at downstream observation sites. However, the uncertainty of specific parameters in space-time RBCM is the main factor affecting the accuracy of estimation. Therefore, a way to solve the parameters efficiently and accurately is essential. For this purpose, a new model which combines space-time RBCM and differential evolution algorithm (DEA) is established to identify the source release history. First of all, efficient parameter optimizer DEA is introduced to search the parameters that affect the estimation accuracy of space-time RBCM. Then, a new loss function considering the imbalance configuration of RBCM nodes is designed to ensure the rationality of the parameters obtained by DEA. The results of numerical cases and real field case show that the proposed method can accurately estimate the real release history with low time consumption. It is also demonstrated that DEA is more efficient than k-fold cross-validation in searching the optimal parameters for space-time RBCM, and the parameters obtained from the new loss function can make the estimated release history more precise.The present study seeks to investigate the use of husbandry waste and sawdust in the construction of degradable pots as a suitable alternative to plastic pots. Six mixture ratios of cattle manure and sawdust (8515, 8020, 7525, 7030, 6535, and 6040) were used along with three types of natural binders (sheep's wool, cornstarch, and sheep's woolcornstarch) in phase I of the project. Phase I was replicated in triplicate to identify the best composition for each binding agent. International standards dictate that evaluations of biological pots include investigations into thickness swelling, internal bonding, and water absorption. Mean comparison of the resultant factorial data using the Tukey and TOPSIS methods indicated that production of bio-pots with a mixture of 80% manure and 20% sawdust may provide the best results for all three pot types. Phase II of the project involved using field experiments and cultivation of tomato plants in direct comparison to a commercial sample pot. The optimal pots for each binding agent in phase I were used in the evaluation. Field tests showed pots produced with 80% manure and 20% sawdust using cornstarch for binding adhesion performed best in terms of degradability and physical and mechanical properties.The chemical contaminants in dried fish are of great food safety concern and an emerging public health issue in Bangladesh. The aim of this study was to assess the public health risk associated with exposure to pesticides (organochlorine and organophosphorus) and heavy metals (lead, mercury, cadmium, chromium, arsenic) through the consumption of dried fish (Bombay duck, ribbon fish, silver jewfish, shrimp, Chinese promfret) in coastal districts (Cox's Bazar, Chittagong, Bhola, Patuakhali, Khulna) of Bangladesh. Selleck Crenolanib Dried fish consumption data were collected from 500 adult respondents (100 from each district) using a food frequency questionnaire (FFQ). Pesticide residues were determined using QuEChERS extraction coupled to gas chromatography and gas chromatography mass spectrometry, and heavy metals were estimated using an atomic absorption spectrophotometric method. The results revealed that the frequency and amount of dried fish consumption was highest for Bombay duck in Cox's Bazar (11.57 g/capita/day) and ribbuilding and consumers' awareness raising strategy.This study projected the future temperature change for Egypt during the late of this century (2071-2100) for three representative concentration pathways (RCP2.6, RCP4.5, and RCP8.5), by correcting regional climate model (RCM) simulations of average, maximum, and minimum daily temperature with reference to observed data of 26 stations. Four commonly used methods of bias correction have been applied and evaluated linear scaling, variance scaling, and theoretical and empirical quantile mapping. The compromise programing results of the applied evaluation criteria show that the best method is the variance scaling, and thus it was applied to transfer the correction factor to the projections. All temperature indices are expected to increase significantly under all scenarios and reach the highest record by the end of the century, i.e., the expected increase in average, maximum, and minimum temperature ranges between 4.08-7.41 °C, 4.55-7.89 °C, and 3.88-7.23 °C, respectively. The largest temperature rise will occur in the summer, with the highest increase in the maximum (minimum) temperature of 10.