Chengstaal5604

Thus, these nanocarriers would be a promising candidate for curcumin delivery in tumor treatment.Formulations based on agar and κ-carrageenan were investigated for the production of emulsion gels applicable as tissue mimicking phantoms. AZD6244 clinical trial The effects of the polysaccharide matrix, the oil content and the presence of surfactants on the micro-/nanostructure, rheology, and mechanical and dielectric properties were investigated. Results showed a high capacity of the agar to stabilize oil droplets, producing gels with smaller (10-21 μm) and more uniform oil droplets. The addition of surfactants allowed increasing the oil content and reduced the gel strength and stiffness down to 57 % and 34 %, respectively. The permittivity and conductivity of the gels were reduced by increasing the oil content, especially in the agar gels (18.8 and 0.05 S/m, respectively), producing materials with dielectric properties similar to those of low-water content tissues. These results evidence the suitability of these polysaccharides to design a variety of tissue mimicking phantoms with a broad range of mechanical and dielectric properties.In this paper, we have isolated cellulose nanocrystallines (CNCs) with different morphologies by enzymatic hydrolysis, and prepared flexible and transparent nanocomposite films with PVA matrix via solution casting. By means of SEM, UV-vis, XRD, DTG, FT-IR and mechanical methods, the effects of rod-shaped cellulose nanocrystallines (RCNCs) and spherical cellulose nanocrystallines (SCNCs) on PVA nanocomposite films were compared systematically. The results showed CNCs with different morphologies had little effect on the transparency of the composite films, and the crystallinity fluctuated with the change of CNCs additive amount. Compared with the RCNCs, SCNCs had a better improve ability to the thermal stability of the composite films by promoting pyrolysis temperature 60-80 °C. On the contrary, the maximum mechanical properties of the composite films of RCNCs were much higher than those of SCNCs, and the Young's modulus of the PVA/RCNCs composite film were increased by 120.97 % in comparison with the pure PVA.Bio-inspired nanotechnology-based strategies are potential platforms for enhanced dissolution and oral biovailability of poorly water-soluble drugs. In this study, a recently patented green biopolymer (Prosopis africana gum, PG) was compatibilized with microcrystalline cellulose (MCC), a conventional polysaccharide, via thermo-regulated coacervation to obtain PG-MCC (10, 11, 12, 21, and 01) rational blends and the nanoparticles developed with optimized (11) biocomposites (termed "prosopisylated cellulose") by combined homogenization-nanoprecipitation technique was engineered as a high circulating system for improved oral bioavailability of griseofulvin (GF), a model Biopharmaceutics Classification System (BCS) Class-II drug. The effects of biopolymer interaction on morphological and microstructural properties of drug-free biocomposites obtained were investigated by Fourier transform infra-red spectroscopy, scanning electron microscopy and x-ray diffractometry, while the physicochemical properties and in-vivo cles showed low plasma clearance with three-fold increase in systemic bioavailability of griseofulvin compared with free drug. These results showed that prosopisylated cellulose nanoparticles would be a facile approach to improve oral bioavailability of BCS class-II drugs and can be pursued as a new versatile drug delivery platform.The present study aims to develop Chitosan-based polymeric nanoparticles of anti-HIV drug Dolutegravir, to aid appropriate dose adjustment and ease of oral administration as milk and food admixture for children. The isolated Chitosan from the crab shell species Portunus Sanguinolentus has been characterized for their physicochemical properties. Nanoparticles were developed with varying ratio of drug Chitosan and assessed for particle size (140-548 nm), zeta potential (+26.1 mV) with a maximum of 75 % drug content. Nanoparticles exhibited improved stability and drug release in the 0.1 N HCl medium compared to pure drug. The MTT assay and the Syncytia inhibition assay in C8166 (T-lymphatic cell line) infected with HIVIIIB viral strain, which showed better therapeutic efficiency and lesser cytotoxicity compared to the pure drug. In consonance with the data obtained, the use of chitosan from a novel source for drug delivery carrier has opened exceptional prospects for delivering drugs efficiently to paediatrics.To solve the trade-off problem among ionic conductivity, mechanical and chemical stability of anion exchange membranes (AEMs), quaternized chitosan (QCS) was first prepared and then was blended with polyvinyl alcohol (PVA) to improve mechanical strength of QCS. Afterwards, three-dimensional (3D) hierarchical flower-like layered double hydroxides (LDHs) were prepared via one-pot ethylene glycol-assisted solvothermal method, and then were incorporated into QCS/PVA blend matrix to fabricate composite AEMs. By constructing 3D hierarchical structure, the active sites of LDH nanosheets are fully exposed, thus impressive ion conductivity, alkali and fuel resistant ability of LDH nanosheets can be rationally utilized. The composite membrane displayed the maximum OH- conductivity of 25.7 mS cm-1, which was 48.6 % higher than that of the pristine membrane. Alkaline stability measurement proved that the composite membranes kept residual ionic conductivity of as high as 92 % after immersion in a 2 M KOH for 100 h. Due to the decreased methanol permeability and increased conductivity, the composite membrane with 6% LDHs content exhibited a peak power density of 73 mW cm-2 at 60 °C, whereas the pristine membrane demonstrated only 40 mW cm-2.An eco-friendly dust suppression and sand-fixation liquid mulching film was prepared via a facile secondary spraying process in this work. Water polyurethane (WPU) was blended with dissolved humic acid (HA) firstly, and then the blend solutions (HWPU) were sprayed on the surface of cationic starch (CS) / sodium lignosulfonate (LS) film to synthesize the liquid mulching film (CLS-HWPU). The effects of liquid mulching film composition on mechanical properties in dry and wet states were investigated. The results showed that the optimal composition of liquid mulching film was 3% (CS), 0.9 % (LS), 1.5 % (glycerol), 2% (HA), and 30 % (WPU). The CLS-HWPU liquid mulching films were characterized in terms of light transmittance, degradation performance test, contact angle test, scanning electron microscopy (SEM), total reflectance-Fourier transform infrared spectrometer (ATR-FTIR), thermo gravimetric analysis (TGA), and erosion resistance test. The results indicated that the CLS-HWPU film had good UV resistance, thermal stability, anti-erosion, and biodegradation.