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Development of osteoarthritis, in patients with knees previously free from articular pathologies, was 4% at 2-3 years (95% CI .02-.07), and 10% at 4-6 years (95% CI .03-.25).
Meniscus repair for traumatic injuries have an all-cause failure rate that increases from 12% to 19% through a time period ranging from 1-6 years following surgery. The failure rates were comparable for patients with meniscal repairs performed with concomitant ACLRs.
IV; Systematic Review of Level II-IV Studies.
IV; Systematic Review of Level II-IV Studies.Di-2-ethylhexyl phthalate (DEHP) exposure is widespread in the general population and previous research has suggested that it contains endocrine-disrupting properties that can adversely affect the reproductive health system. https://www.selleckchem.com/products/abr-238901.html The objective of this study was to use the 2013-2016 National Health and Nutrition Examination Survey (NHANES) data to assess the potential association between DEHP exposure and infertility in women. Using a nationally representative, cross-sectional study design, we used multiple logistic regression to measure the association of urinary metabolites of DEHP with self-reported history of infertility among women. Four metabolites of DEHP were examined mono(2-ethylhexyl)phthalate (MEHP), mono(2-ethyl-5-hydroxy-hexyl)phthalate (MEHHP), mono(2-ethyl-5-oxy-hexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxy-pentyl)phthalate (MECPP). These metabolites were calculated into a molar sum of DEHP (∑DEHP) and split into quartiles for analysis. After adjusting for age and race, ∑DEHP was associated with increased odds of infertility for the second quartile (AOR = 2.35, 95% CI [1.24,4.44], p = 0.01) and third quartile (AOR = 2.83, 95% CI [1.57, 5.10], p less then 0.01) when compared to the first quartile (reference). The adjusted OR for the highest quartile of ∑DEHP found no association and it was not statistically significant (AOR = 0.99, 95 %CI [0.57, 1.73], p = 0.98). The findings of this study add to the already complex existing literature on phthalate exposure and infertility. These findings warrant further population-based cohort studies on phthalate exposure and their relationship to infertility in humans.
Extracts of the stem bark of Ficus paltyphylla (FP) are used in the Nigerian traditional medicine to manage psychoses, depression, epilepsy, pain, and inflammation. Our previous studies revealed that the methanol extract of FP ameliorate body core temperature.
A number of pharmacological agents that utilize mechanisms that enhanced neuronal survival and/or neural regeneration have been developed for the treatment of stroke. Hypothermia protects the brain from damage caused by ischemia by attenuating destructive processes such as neuroinflammation, excitotoxicity, blood-brain barrier disruption, apoptosis, and free radical formation following cerebral ischemia. In the present study, we examined the neuroprotective potential of FP on permanent occlusion of the middle cerebral artery (MCAO)-induced ischemia in mice.
C57Bl mice were subjected to MCAO. FP was administered 1h prior to and immediately after surgery. The brains were collected 24h later and infarct volumes were measured using immune-histochemical staining, DAPI, NeuN, synaptophysin, and NR2B were quantified.
Administration of FP prior to MCAO significantly reduced infarct volume, with no effect on infarct volume immediately after MCAO. Higher numbers of cells and neurons were observed in the peri-infarct area in both groups of mice. FP-induced hypothermia protected tissue in the peri-infarct region from synaptophysin reduction. NMDA receptor 2 (NR2B) immunoreactivity is enhanced by MCAO, with no difference observed in both sham-operated and FP-induced hypothermia groups of mice.
The data suggest that FP might be useful in the reduction of ischemia-induced infarct volume when administered prior to the initiation of ischemia with no effect observed after ischemia induction.
The data suggest that FP might be useful in the reduction of ischemia-induced infarct volume when administered prior to the initiation of ischemia with no effect observed after ischemia induction.
Berberine is a quaternary ammonium isoquinoline alkaloid, mainly extracted from plants berberaceae, papaveraceae, ranunculaceae and rutaceae such as coptis chinensis Franch, Phellodendron chinense, and berberis pruinosa. The plants are extensively used in traditional medicine for treating infection, diabetes, arrhythmia, tumor, osteoporosis et al. Pharmacological studies showed berberine has effects of anti-inflammation, anti-tumor, lower blood lipid, lower blood glucose, anti-osteoporosis, anti-osteoarthritis et al. AIM OF THE STUDY This review aims to summarize the application of natural herbs that contain berberine, the further use and development of berberine, the effects as well as mechanism of berberine on osteoblasts and osteoclasts, the recent advances of in vivo studies, in order to provide a scientific basis for its traditional uses and to prospect of the potential applications of berberine in clinics.
The research was achieved by retrieving from the online electronic database, including PubMed,ing alternative to bone regeneration engineering, with broad potential for therapeutic and clinical practice.
This review has systematically summarized the application, pharmacological effects, mechanism as well as in vivo studies of berberine and herbs which contain berberine. Berberine has a definite effect in promoting the proliferation and differentiation of osteoblasts as well as inhibiting the production of osteoclasts to promote bone regeneration. However, the present studies about the system mechanisms and pharmacological activity of berberine were incomplete. Applying berberine for new drug development remains an exciting and promising alternative to bone regeneration engineering, with broad potential for therapeutic and clinical practice.
Many studies are performed with the aerial parts of Cannabis sativa L. (Cannabaceae). However, roots remain poorly studied, despite citations in the scientific literature. The C. sativa roots are indicated for the treatment of pain, inflammation, fever, among other health problems.
This study aimed to evaluate the antinociceptive, antipyretic, antiasthmatic, and spasmolytic activities of C. sativa roots in experimental models using mice and rats.
The chemical composition of the aqueous extract of C. sativa roots (AECsR) was evaluated by LC-MS. The antinociceptive activity was assessed in mice by the induction of writhing with acetic acid, paw licking with formalin, and reactivity in the hot plate test. Fever was induced by the administration of a suspension of Saccharomyces cerevisiae in young rats. The asthmatic activity was performed with ovalbumin (OVA)-immunized mice with cellular and histological analysis. Finally, the spasmolytic activity was performed using mice isolated trachea. For in vivo studperivascular and peribronchial region, as well as reduced mucus production.
The results suggest that AECsR promotes pain control, either by a central or inflammatory mechanism, and has antiasthmatic activity. However, there was no antipyretic or spasmolytic effect.
The results suggest that AECsR promotes pain control, either by a central or inflammatory mechanism, and has antiasthmatic activity. However, there was no antipyretic or spasmolytic effect.
Brazilian medicinal species of the Psidium genus are rich in secondary metabolites such as terpenes and phenolic compounds and present biological activities for several human diseases. For the native Psidium species, there are no specific research reports for any member of the genus about ethnobotanical research, hindering the joint analysis of its therapeutic indications together with the scientific evidence already investigated.
Analyze the therapeutic indications, the main chemical constituents, and the biological activities of native species of the Psidium to Brazil.
Systematic research was carried out in the Scopus, ScienceDirect, PubMed, and Web of Science databases over a period of ten years. Articles in English, Portuguese and Spanish were used. The research was divided into three phases, seeking information on ethnobotany, chemical composition and biological activities. The words were combined to structure the descriptors used in the search.
A total of 13 native species belonging to the Psidithe biological activities demonstrated for the species.
Native species of the Psidium genus are important sources of active ingredients in combating adversities that affect the human health, especially regarding the digestive system. They have a rich chemical composition, responsible for the biological activities demonstrated for the species.
Khaya grandifoliola is a well-known tree species in Africa with a conservation status of 'vulnerable' due to its overexploitation by the wood industry. Several studies have recorded numerous ethnobotanical uses of this plant, as well as the scientific validation of the efficacy of extracts from different plant parts used for the treatment of various ailments. However, this useful information is scattered throughout the literature and thus there is no opportunity to identify the existing knowledge gaps.
This review aims to highlight the medicinal importance of Khaya grandifoliola including its known phytochemistry, biological activities and toxicology, to encourage a refocused conservation strategy since all current efforts are geared towards maintaining its continuous supply to the wood industry.
Articles on K. grandifoliola were sourced from online databases such as Google Scholar, Medicine, PubMed, Science Direct, Scopus, SciFinder and other science journal websites up to May 2020. The search was condicinal uses are also well supported with scientific studies as well as favourable toxicological studies though some scientific knowledge gaps require further studies.
Notwithstanding the importance of K. grandifoliola in the wood industry, this review reveals that its use as a medicine is equally important. Its medicinal uses are also well supported with scientific studies as well as favourable toxicological studies though some scientific knowledge gaps require further studies.Almost three billion people in developing countries are exposed to biomass smoke (BS), which predisposes them to developing chronic obstructive pulmonary disease (COPD). COPD is associated with abnormal innate and adaptive immune responses in the lungs and systemic circulation, but the mechanisms underlying BS-COPD development are uncertain. We investigated the role of dendritic cells (DCs) and interleukin (IL)-17A in BS-COPD. We investigated T helper cell responses in the BS-exposed COPD rat model by flow cytometry, quantitative PCR, and enzyme-linked immunosorbent assays. We conducted ex vivo experiments to determine which antigen-presenting cells induce Th17 cell responses. We evaluated the in vitro effects of BS-related particulate matter (BRPM) (2.5 μm) on the function of bone marrow-derived dendritic cells (BMDCs). We found that BS exposure enhanced Th17 responses in the lungs of the COPD-modelled rats, and the stimulated DCs (but not the macrophages) were sufficient to induce naïve CD4 + T cells to produce IL-17A in ex vivo experiments.
