Barrerabauer2601

Closed-Loop Control (CLC) has been shown to improve glucose time in range and other glucose metrics; however, randomized trials longer than 3 months comparing CLC with sensor-augmented pump (SAP) therapy are limited. We recently reported glucose control outcomes from the 6-month international Diabetes Closed Loop (iDCL) trial; we now report patient-reported outcomes (PROs) in this iDCL trial.

Participants were randomized 21 to CLC (N=112) versus SAP (N=56) and completed questionnaires including Hypoglycemia Fear Survey, Diabetes Distress Scale (DDS), Hypoglycemia Awareness, Hypoglycemia Confidence, Hyperglycemia Avoidance, and Positive Expectancies of CLC (INSPIRE) at baseline, 3, and 6 months. CLC participants also completed Diabetes Technology Expectations and Acceptance and System Usability Scales (SUS).

The Hypoglycemia Fear Survey Behavior subscale improved significantly after 6 months of CLC compared with SAP. DDS did not differ except for powerless subscale scores, which worsened at 3 months in SAP. Whereas Hypoglycemia Awareness and Hyperglycemia Avoidance did not differ between groups, CLC participants showed a tendency towards improved confidence in managing hypoglycemia. The INSPIRE questionnaire showed favorable scores in the CLC group for teens and parents, with a similar trend for adults. At baseline and six months, CLC participants had high positive expectations for the device with Diabetes Technology Acceptance and SUS showing high benefit and low burden scores.

CLC improved some PROs compared with SAP. Participants reported high benefit and low burden with CLC.

CLC improved some PROs compared with SAP. Participants reported high benefit and low burden with CLC.Background The morbidity and mortality of interstitial lung disease (ILD) is high, despite novel therapeutics. Recognizing unmet needs for symptom management, advance care planning (ACP), and support for people with ILD and their families, we developed a palliative care-ILD collaborative care pilot program to improve access to palliative care. Methods In the quantitative arm of this mixed-methods study, we evaluated which patients were cared for through the palliative care co-management program and the impact of the program on rates of ACP and opioid prescribing. In the qualitative arm, we interviewed patients and family caregivers, as well as pulmonary and palliative care clinicians, to understand perceptions about palliative care. Results Thirty-one patients were co-managed by the palliative care and ILD teams during the study period. AR-A014418 mouse Half (48.4%) had idiopathic pulmonary fibrosis. Mean forced vital capacity (FVC) was 61.7%. Nearly half (48.4%) received all of their palliative care via telehealth. With pallls. Ongoing challenges include systematically reaching all patients who are likely to benefit.The conformability is yet a challenge for most soft robotic grippers due to the continuous motion and deformation of these machines under external force. Herein, inspired by the movement mechanism of human fingers, we propose a novel tendon-driven soft robotic finger with a preprogrammed bending configuration and a human finger like sequential motion that can be obtained by matching the stiffness gradient of the finger joints with three-dimensional (3D) printing technology. The contents of this article are organized as follows. First, the effect of the anisotropy caused by 3D printing filling direction on the mechanical property is investigated by tensile test. Then, kinematic, stiffness, and fingertip trajectory models are established to analyze the influence of the cross-section thickness and width on the bending and bearing capacity of the finger joint. Furthermore, several experiments are conducted on a self-built experimental platform to evaluate the advantages of sequential motion induced by stiffness gradients. Results reveal that soft robotic fingers with sequential motion show excellent conformability on the object surfaces with various curvatures and outperform nonsequential motion fingers with larger envelop range. Without changing motion trajectories of the fingertip, the deformability of the finger can be tuned by adjusting only the stiffness of the joint. Besides, a two-finger gripper is developed, which presents the capability of grasping objects with different shapes and weights in practical applications. The sequential motion mechanism proposed in this study shows promising potential in soft grippers and robotic design.

To measure the changes in the number of medical visits and the number of HbA1c determinations according to telemedicine access in children with type 1 diabetes (T1DM) during the pandemic 2020 compared with 2019 and 2018.

This is a multinational study of children with T1DM from four Latin American countries. The number of medical visits, the number of HbA1c determinations, and access to telemedicine during 2020 were extracted from their records.

227 children (59% females) aged 12.7± 3.2 years with a duration of 5.4 ± 2.7 years of T1DM in 2018 were evaluated. There was a higher prevalence of children with telemedicine access in the pandemic 2020 vs. those without (145(63.9%) vs. 82 (36.1%); p<0.01) There was a higher number of medical visits during 2020 in children with telemedicine access vs. those without (6.9 vs. 2.6; p<0.01). Children with telemedicine access had a higher number of visits in 2020 vs. 2018 (6.87 vs. 5.04, p<0.01), but similar to 2019. Children without access had a lower number of visits in 2020 vs. 2019 (2.6 vs. 5.5; p<0.01) and vs. 2018 (2.6 vs. 5.1; p<0.01). In 2020, the number of HbA1c determinations in children with telemedicine access was higher vs. those without (1.8 vs. 0.9; p<0.01). Children with telemedicine access had a lower number of Hb A1c determinations in 2020 vs. 2019 (1.8 vs. 2.4; p<0.01), but similar to 2018. Furthermore, children without access had a lower number of Hb A1c determinations in 2020 vs. 2019 (0.9 vs. 1.9; p<0.01) and vs. 2018 (0.9 vs. 2.0; p<0.01).

We found that children with T1DM with telemedicine access had a significantly higher number of medical visits and HbA1c determinations during lockdown than those without access in different Latin American centers.

We found that children with T1DM with telemedicine access had a significantly higher number of medical visits and HbA1c determinations during lockdown than those without access in different Latin American centers.Purpose Sexual and gender minority (SGM) and racial/ethnic minority populations may differ in coronavirus disease 2019 (COVID-19) prevention, testing, and vaccine interest, although little research has explored these disparities. It is critical to understand the differential experiences within minoritized communities to ensure effective intervention and vaccine rollout. Methods In a national online survey of U.S. adult SGM individuals, conducted between April and August 2020, 932 participants responded about COVID-19 testing, symptoms, interest in vaccination, and interest in at-home testing. Bivariate associations between these outcomes and demographic factors, including sexual orientation, gender identity, endorsing intersex traits, gender modality, race/ethnicity, and HIV status were calculated. Results Despite 24% of the sample reporting COVID-19 symptoms, testing was relatively low at 13.3%. Transgender and bisexual/pansexual individuals were more likely to be interested in a COVID-19 vaccine and an at-home test compared with cisgender and gay/lesbian respondents, respectively. Compared with cisgender individuals, transgender individuals were nearly twice as likely to report COVID-19 symptoms. Latinx individuals were less likely to be interested in a future COVID-19 vaccination and Black individuals were less likely to be interested in an at-home COVID-19 test compared with White participants. Both respondents who endorsed intersex traits and people with HIV were less likely to be interested in an at-home test compared with those who did not endorse having intersex traits and people without HIV, respectively. Conclusions These results show critical disparities in COVID-19 symptomology and prevention interest within SGM populations that must be taken into account when designing or tailoring effective COVID-19 interventions.Transcripts of uncertain coding potential (TUCP) are part of long noncoding RNAs, which include short open reading frames and could be translated into small peptides. In recent years, a growing number of TUCPs has been implicated in multiple biological activities, such as embryogenesis and transcriptional regulation. However, the abundance of TUCPs and their roles in goat endometrium during pregnancy recognition (day 16) remain undocumented. In this study, bioinformatics analyses were conducted to identify the differentially expressed (DE) TUCPs between pregnant animals and corresponding nonpregnant controls. A total of 5551 TUCPs were identified; 114 TUCPs were DE in goat endometrium, of which 74 TUCPs were upregulated in pregnant endometrium, whereas 40 TUCPs were downregulated. The related genes of TUCP were predicted by using coexpression and colocalization methods. In summary, 419 genes were predicted by colocalization, and 9464 genes were predicted by coexpression. The kyoto encyclopedia of genes and genomes (KEGG) and gene ontology (GO) analysis showed that TUCPs, which are highly expressed in pregnant endometrium, were mainly associated with endometrial remodeling, nutrient synthesis, and transportation. However, TUCPs that were lowly expressed in pregnant endometrium were mainly associated with immune tolerance, which is necessary for the protection and development of the embryo in the uterus. These findings may be used for the comparative analysis of TUCP transcripts in endometrium and assist in the selection of applicable candidate genes associated with embryo implantation for further functional analyses.Objective This clinical trial evaluates the effect of erbium, chromiumyttrium-scandium-gallium-garnet (Er,CrYSGG) root surface biomodification and laser harvesting of de-epithelialized gingival graft (DGG) on root coverage clinical outcomes and postoperative morbidity, and compares this to the conventional blade-harvested DGG method without Er,CrYSGG root surface biomodification in treatment of Miller's class I, II gingival recessions (GR). Background The application of laser technology to enhance tooth root coverage clinical outcomes as well as the impact of laser on postoperative morbidity after harvesting autogenous soft tissue grafts requires further research. Methods This study is a randomized, single-blinded controlled trial, including 24 volunteers with isolated GR defects. They were allocated into three treatment groups to receive one of the following three interventions blade-harvested DGG (control group B-DGG); Er,CrYSGG-harvested DGG and root surface biomodified [test 1 group L-laser-harvested DGG (L-DGG)/laser root biomodification (LRB)]; and B-DGG and Er,CrYSGG root surface biomodification (test 2 group B-DGG/LRB). Clinical and radiographic parameters were recorded at baseline (1 week before surgery) and 3, 6, and 9 months postoperatively. Results Root coverage did not show a statistically significant difference between control and test groups. Statistically significant differences were found for Visual Analog Scale on the day of surgery and day 3 and 4 postoperatively, as well as pain medication on the day of surgery favoring the L-DGG group. Conclusions The use of Er,CrYSGG laser in root surface biomodification improved root coverage outcomes at 9 months. Even these changes were not statistically significant from the control group; the L-DGG technique was associated with decreased postoperative morbidity in the palatal donor site.