Buckrodriquez7491
Weakness is a frequent complication in those critically ill due to COVID-19. This study describes its characteristics and the factors that can condition and predict it.
We conducted a prospective, descriptive, observational study of patients admitted to the intensive care unit (ICU) due to COVID-19 between April and May 2020 with muscle weakness. A motor balance equal to or lower than 3/5 according to the modified Medical Research Council muscle strength scale was considered to be severe clinical impairment. Altogether 25 analytical studies, 16 neurophysiological studies and one muscle biopsy were performed, with a telephone follow-up at one month, a comparative analysis between the groups with and without severe compromise, and determination of cut-off points for analytical parameters to predict severe involvement using ROC curves.
The sample consisted of 25 patients with a mean age of 58 years (standard deviation ± 9). The median length of stay in the ICU was 27.5 days. All the electromyograms exhibitathophysiology.
Recovery of all brain functions affected after stroke is essential for the patient's quality of life, with comprehensive rehabilitation key.
Identify social and environmental factors affecting access to comprehensive post-ictus rehabilitation, and assess long-term effects of comprehensive rehabilitation on patient functionality.
171 consecutive patients (84 women and 87 men) hospitalized in 2015 in Neurology Service with first ischemic stroke, without prior functional dependence, candidates for comprehensive rehabilitation are studied. Various socio-environmental and clinical variables potentially associated with access to it are analyzed. The long-term prognostic impact (average period of 54 months) on the functional situation is studied using the Barthel index.
The average age of patients is 69 years. Only 53% were able to access the recommended comprehensive rehabilitation. Predictor variables of access were resulted residence in urban environment (OR 2,957; 95% CI 1,067-8,199; p = 0.037), complement with private rehabilitation (OR 2,89; 95% CI 1,130-7,392; p = 0.027), best Rankin to high (OR 22,437; 95% CI 3,247-155,058; p = 0.014). After average follow-up for 54 months, of the 137 survivors, access to comprehensive post-ictus rehabilitation was independently associated with better long-term functional situation (OR 12,441; 95% CI 4.7-32.5; p < 0.001).
Comprehensive post-ictus rehabilitation is associated with better long-term prognosis, but access to it is conditioned by environmental and social factors such as the place of residence and the possibility of contracting private services.
Comprehensive post-ictus rehabilitation is associated with better long-term prognosis, but access to it is conditioned by environmental and social factors such as the place of residence and the possibility of contracting private services.Seborrheic keratoses (SKs) are benign lesions of uncertain etiology, which can develop in both genital and extra-genital locations. For genital SKs, there has been conjecture about the pathogenic role of human papillomavirus (HPV), in view of the frequent association of this virus with genital lesions. In light of the potential consequences on patient management, we investigated the relationship between HPV and SKs of the female genital tract (FGT). For this, we evaluated the current evidence on this relationship by performing an in-depth review of the literature. Furthermore, to add to the evidence on this association, we investigated the presence of HPV in a series of vulvar SKs (n=15), using a novel multimodal approach. This involved whole tissue section-polymerase chain reaction (WTS-PCR) using SPF10-DEIA-LipA25 for HPV detection and genotyping. In addition, immunohistochemistry (IHC) was performed with cellular biomarkers p16 and MIB-1, and viral biomarker E4, to augment HPV-testing. Finally, laser-capture microdissection-PCR (LCM-PCR) was performed to locate HPV to specific lesional cells, and to rule out incidental detection of resident HPV with WTS-PCR. Our findings from the literature review, as well as, the case-series are presented.
This study aimed to compare the morphometric characteristics of the foramen ovale (FO) and rotundum (FR) and their localization in the middle cranial fossa in head and neck computed tomography images in patients with trigeminal neuralgia (TN) and asymptomatic individuals.
FO and FR length, width and area parameters were examined in 158 asymptomatic individuals and 19 patients with TN. Their location in the middle cranial fossa was determined according to the sagittal (y) axis passing through the middle of the dorsum sella and connecting the foremost point and the rearmost point of the skull, and the transverse (x) axis passing through the middle of this axis. In comparisons with asymptomatic individuals, data on the painful side of patients with trigeminal neuralgia were used.
The mean width of the FO and its distance from the transverse axis were determined 3.36±0.79 mm and 1.44±0.39 mm in asymptomatic individuals, 2.88±0.83 mm and 1.23±0.45 in TN patients, respectively. These FO parameters were statise of the causes of TN.
To elucidate the association of the MTHFR, MTRR, and RAD54L gene variations with meningioma in Turkish cohort.
DNAs were isolated from 87 retrospective meningioma samples. The MTHFR, MTRR, and RAD54L gene hotspot regions were amplified with specific primers via polymerase chain reaction (PCR), and next-generation sequencing (NGS) was performed. All the detected variations and single-nucleotide polymorphisms (SNPs) were listed and compared with healthy control frequencies in different genomic databases. The histopathological characteristics of meningiomas and genomic variations were compared. Pearson?s chi-squared test was used to detect the statistical differences of SNPs, and correlation analysis was conducted.
rs1801131, rs1801133, and rs4846051 on MTHFR, rs1801394 on MTRR, and rs1048771 on RAD54L gene frequencies were found to be significantly altered in the overall cohort of 87 patients with meningioma. The frequency of rs18011031 is 0.09 in the meningioma cohort, which is significantly correlated wry promising study conducted to establish the genetic marker analysis for meningioma diagnosis and prognosis for folate metabolism and DNA repair genes in Turkish cohort.
We reported a significant association between the genetic alterations of folate metabolism (MTHFR, MTRR) and DNA repair mechanism (RAD54L) genes with the histopathological characteristics of meningioma. Five significant SNPs on these genes and four significant correlations of SNPs with histopathological characteristics were identified. This is a preliminary promising study conducted to establish the genetic marker analysis for meningioma diagnosis and prognosis for folate metabolism and DNA repair genes in Turkish cohort.
Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy (HMSN) is the definition of a genetically heterogeneous group of diseases characterized by the impaired function of peripheral nerves. The aim of this study was to investigate the genetic etiology of CMT.
We herein examined 55 non-related patients with a suspicion of CMT phenotype or HMSN using a customized multigene panel based on the next-generation sequencing technique. All cases were previously analyzed for PMP22 duplication with the Multiplex Ligand Probe Amplification (MLPA) method.
In 13 cases (7.15%), we identified a pathogenic/likely pathogenic variants. The affected genes were MARS1, NDRG1, GJB1, GDAP1, MFN2, PRX, SH3TC2, and FGD4. In six cases (10.9%), novel variants were identified pathogenic variants in GJB1 and FGD4 genes, variants of unknown significance (VUS) in HSPB3, CHRNA1, ARHGEF10, and KIF5A genes. In 21 cases (11.55%), VUS with the genes HSPB3, KIF1B, SCN11A, CHRNA1, HSPB1, FIG4, ARHGEF10, DHTKD1, SBF1, EGR2, SBF2, IGHMBP2, KIF5A, and DNAJB2 were identified.
In this study, we had a 7.15% diagnosis rate with the NGS (Next Generation Sequencing) method in the CMT disease. Targeted next-generation sequencing panels are beneficial, time-saving, and cost-effective in the diagnosis of CMT.
In this study, we had a 7.15% diagnosis rate with the NGS (Next Generation Sequencing) method in the CMT disease. Targeted next-generation sequencing panels are beneficial, time-saving, and cost-effective in the diagnosis of CMT.
Ischaemic moyamoya disease (MMD) can affect both children and adults; however, there seem to be differences in brain perfusion stages defined by the computerised tomography perfusion (CTP) image scale system before surgery. In this study, we aimed to clarify perfusion differences and determine whether children and adults respond similarly to surgical prevention and how brain perfusion stages before surgery predict outcomes in ischaemic MMD in children and adults.
A total of 355 patients with ischaemic MMD, including 74 children and 281 adults, were enrolled in the study. CTP scans were used to identify the perfusion status according to a novel staging system of the pre-infarction period. The perfusion status of each hemisphere between the children and adult groups was analysed. The modified Rankin scale was used during long-term follow-up as an indicator of clinical outcomes.
The proportions of stages 0 and Ⅳ in adults were significantly higher than those in children (p = 0.09 and p = 0.003, respectively). Stage Ⅲ was more common in the children's group (p = 0.001). The stroke data showed an increasing tendency in the infarction rate from stages I to Ⅳ. Both groups in stage 0 and in the early stages had a similar highly improved ratio after surgery; the children, however, achieved significantly better clinical outcomes in stage Ⅲ and late stages.
There are differences in the perfusion status between child and adult patients with MMD. The pre-infarction staging system is associated with MMD-related stroke to some extent. Children have a greater chance for improvement than adults in stage Ⅲ and later stages.
There are differences in the perfusion status between child and adult patients with MMD. The pre-infarction staging system is associated with MMD-related stroke to some extent. Children have a greater chance for improvement than adults in stage Ⅲ and later stages.
Epidural hematoma (EDH) is a commonly encountered neurosurgical condition. Numerous articles have been published on EDH. Bibliometric analysis studies the chronological trends and ranks the most impactful articles in a given field. The aim of this paper is to analyze the most-cited articles on cranial and spinal EDH.
A title-specific search was performed on the Scopus database using the term "epidural hematoma" in June 2020, with no publication date restrictions. The top 100 most-cited articles were collected, reviewed, and analyzed.
A total of 2165 articles were published on EDH from 1949 to 2020, and the top 100 most-cited ones were published between 1966 and 2014, receiving an average citation of 84.7 per paper. Most papers were published in Neurosurgery and Journal of Neurosurgery (JNS). 48% of the most-cited articles on EDH originated from the United States of America (USA). Notably, studies on spinal EDH represented 75% of the most-cited articles in our review. find more The most-cited article on EDH was published by Lawton et al.
