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Our work provides an effective oral therapeutic strategy for CRC therapy by modulating the colorectal tumor inflammatory microenvironment and sheds light on the route for oral nano-materials in the clinical treatment of CRC.Ammonium borohydride, NH4BH4, has the highest gravimetric and volumetric hydrogen density among known inorganic compounds and a fascinating rock salt type crystal structure composed of H disordered tetrahedral complexes, NH4+ and BH4-, which are interlinked by a dense network of dihydrogen bonds. Here we report the synthesis, structure and properties of solid solutions in the binary systems, NH4BH4-MBH4 (M = K, Rb, Cs), which are investigated by in situ synchrotron radiation powder X-ray diffraction and thermal and photographic analysis. Full solubility and formation of (NH4)xM1-xBH4, is observed upon cryo-mechanochemical treatment. The solid solutions stabilize NH4BH4 from T ∼68 to ∼96 °C, alter the decomposition pathway and suppress the fierce decomposition of NH4BH4. However, for increased amounts of NH4BH4 in the solid solutions, the decomposition gradually shows more resemblance to that of pristine ammonium borohydride, and the thermal stability of the solid solutions appears to decrease down the group of the alkali metal ions, i.e. decreasing from K+, Rb+ and to Cs+.Schizophyllum commune is a widely distributed basidiomycete fungus that occasionally causes sinusitis or allergic bronchopulmonary mycosis. The invasive infection mostly occurs in immunocompromised adults. The number of reports on S. commune infection have increased in this decade due to the expansion of diagnostic techniques and awareness in clinical practice. However, S.commune infection in patients with primary immunodeficiencies has not been reported yet. Here, we described S. commune-abscesses developed in the brain and lung of a boy with chronic granulomatous disease (CGD) after allogenic hematopoietic cell transplantation (HCT). A 12-year-old CGD patient developed febrile neutropenia from day 4 after HCT, followed by chest pain on day 23. He had no obvious infection before HCT. Diagnostic imaging revealed disseminated lung and brain abscesses. He received administration of voriconazole, and his symptoms improved after engraftment. Chronic administration of voriconazole had also a favorable therapeutic response to brain lesion. A part of the fungus ball exhaled by the patient was cultured to develop a filamentous fungus. S. commune was identified by the analysis of the 28S rRNA gene. The catalase test was positive for S. commune, indicating that S. commune had virulence in this patient with CGD. The assessment of specific-IgG to S. commune suggested peri-transplant infection, although colonization was not excluded. This rare pediatric case of S. commune infection highlights that CGD patients are vulnerable to invasive infection, especially when undergoing HCT.Cellulose nanocrystals (CNC) exhibit great potential as a food emulsifier or functional material template. Herein, CNC-Fe nanoparticles were successfully prepared via an in situ chemical reduction approach. Zeta potential measurements, low-field nuclear magnetic resonance spectroscopy, and atomic force microscopy showed that Fe(III) ions were adsorbed onto CNC when FeCl3 was added to a CNC dispersion. Micromorphological analysis revealed small (diameter = 10.0 ± 2.4 nm) spherical nanoparticles synthesized on the surface of aggregated CNC after the reduction of the Fe(III) ions. Fourier transform infrared spectroscopy revealed an intense peak at 779 cm-1 in the CNC-Fe nanoparticles, which was attributed to FeO stretching vibrations. X-ray photoelectron spectroscopy indicated that the valence state of Fe in CNC-Fe nanoparticles was predominantly ferrous. The synthesized CNC-Fe nanoparticles demonstrated excellent colloidal stability in a dispersion for 21 d and complete, rapid, and spontaneous dissolution in vitro simulated gastric fluid. Our results highlight the potential use of CNC as a template for loading Fe into nanoparticles for Fe fortification in food.This study proposes 3D-printed Poly L-lactic acid (PLA) scaffolds coated with alginate/MgO, and includes three different cellular topologies. Three unique scaffold models were considered Perovskite type 1 (P1), Perovskite type 2 (P2), and IWP. Each scaffold was coated with alginate/MgO at the concentrations of 0 wt%, 5 wt%, 10 wt%, 15 wt%, and 20 wt%. For morphological and phase study, the microstructure of fabricated scaffolds was characterized using a Field Emission Scanning Electron Microscope (FESEM), energy dispersive spectroscopy (EDS), and X-ray diffraction (XRD) analysis. Besides, the biological characteristics of scaffolds, such as biocompatibility, antibacterial activity, and cell survival were studied after 21 days of soaking in the simulated body fluid (SBF). The results of biological studies indicate that the apatite layer covered the majority of composite scaffold's surface and sealed the pores' surface. The material properties of Alginate/MgO RVEs were evaluated under PBC, and it described thatate.There is a tremendous increase in the development of alternative food packaging materials which are functional, environment-friendly, and can improve the shelf-life of food products. One such possible approach is to develop biopolymer-based active films loaded with antimicrobial essential oils. In the present study, pearl millet starch (PMS) films reinforced with kudzu cellulose nanocrystals (CNCs) stabilized Pickering emulsions of clove bud oil (CBO) were developed as active and sustainable packaging material. Selleck AG-221 Active nanocomposite films were prepared by blending PMS with Pickering emulsions of CBO at 0.5, 1, 1.5, and 2 wt% conc. Using the solution casting method. Overall, active nanocomposite films displayed improved thermal, mechanical, and water barrier properties, with an optimum CBO-Pickering emulsion concentration of 1.5 %. CBO and PMS films showed strong chemical interactions, which significantly improved the mechanical resistance of the film. Further, SEM showed the appearance of micro-porous holes in the films because of partial evaporation on the cryo-fractured surface due to the vacuum condition. In addition, films exhibited antimicrobial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), with a rate response from increasing CBO Pickering emulsion concentration from 0.5 to 2 %. E. coli and S. aureus exhibited an inhibition zone ranging from 10.5 to 2.15 mm and 11.2 to 22.1 mm. This study suggests that PMS starch and kudzu CNCs-based active nanocomposite films loaded with CBO-Pickering emulsions have good potential to develop active and sustainable packaging materials.Functional particles, such as microcapsules of perfumes, enzymes, or anti-mite agents, are desired to stably suspend in the high-content surfactant solution, providing additional functionalities for household products. Due to the disassociation of high-content surfactant, most linear or branched polymers would fail to modify the rheological properties of the high-content surfactant solution, especially for the suspending ability. In this research, the 2,2,6,6-tetramethylpiperidine-1-oxyl oxidized bacterial cellulose microgel (T-microgel) and hydroxypropyl methylcellulose (HPMC) were employed as "island" and "chain," respectively, which could self-assemble together to fabricate a yield and thixotropic continuous network in a high-content surfactant solution. The suspending ability of microgel in high-content surfactant is better than cellulose nanofiber and carboxymethylcellulose. This is the first time to report a cellulose microgel-based rheological modifier. T-microgel/HPMC synthetic system mixed with high content surfactant presented a typical Carreau-Yasuka fluid. Meanwhile, the effects of the HPMC and surfactant on the rheological properties of the combined system were investigated, and an optimal ratio for the 'island'/'chain' synthetic system was found to modify its yield and thixotropy behavior successfully. The potential application of this combined system was explored and found to work with all kinds of surfactants at high concentrations, which is more advantageous than most commercial suspending agents.In this study, maltodextrin (MDex), lutein pigment (Lut) and alumina (Al) were used to modify biodegradable film based on cress seed mucilage (Muc/MDex/Lut/Al). Central composite design (CCD) was used to study the effects of MDex, Lut and Al on the physical and chemical properties of the mucilage based film. The physicochemical, mechanical, antimicrobial and structural properties of the films were studied by various techniques such as FTIR, SEM, and XRD and TGA. The release of lutein from the film was investigated at 25 °C for 15 days. The results showed that lutein, alumina and maltodextrin increased the film thickness and lutein decreased the solubility and moisture content of the film. Maltodextrin improved the mechanical properties of the film and lutein reduced the film's flexibility. Lutein greatly increased its antioxidant properties, but alumina slightly increased its antioxidant properties. Lutein, alumina and maltodextrin improved the antibacterial properties of the film. Muc/MDex/Lut/Al film showed 26 ± 0.5 and 23 ± 0.8 mm non-growth halo against to Staphylococcus aureus and Escherichia coli, respectively. Maltodextrin filled the surface cracks, but lutein increased the surface cracks of mucilage film. The amorphous structure of the pure cress seed mucilage film was confirmed by XRD, which the alumina and lutein gave crystalline properties in the film. Maltodextrin and alumina increased the thermal stability of the film. The release results showed that the release rate of lutein depends on the structure of the film and by changing the structure of the film, the release rate can be purposefully controlled according to the required release rate.For both nacre formation and biomineralization in mollusks, understanding the molecular mechanism is imperative. Biomineralization, especially shell formation, is dedicatedly regulated by multiple matrix proteins. However, ACC conversion to stable crystals still lacks positive factors. In this research, we found a novel matrix protein named PNU5 in Pinctada fucata that plays a regulatory role in both prismatic layer and nacreous layer formation. Functional studies in vivo and in vitro have shown that it might be involved in shell formation in a positive manner. RT-qPCR analysis showed that pnu5 was highly expressed in mantle pallial and participated in shell repairing and regeneration. RNAi-mediated repression of pnu5 could affect the normal structure of prismatic layer and nacreous layer. The recombinant protein rPNU5 significantly enhanced the precipitation rate of CaCO3 both in the calcite and aragonite crystallization systems, as well as altering the morphology of the crystals. Based on ACC transition experiments, the recombinant protein rPNU5 facilitated amorphous calcium carbonate (ACC) transformation into stable calcite or aragonite. This study could provide us with a better understanding of how positive regulatory mechanisms contribute to biomineralization.Two sodium alginate-based Pb2+-imprinted thermosensitive hydrogels (SPIT (without ɛ-PL) and SPPIT (with ɛ-PL)) were synthesized, with sodium alginate and ɛ-polylysine (ɛ-PL) as the matrix, N-isopropylacrylamide as the monomer. Characterization with differential scanning calorimeter, Fourier transform infrared spectroscopy, thermogravimetric analyzer, scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy confirmed the aimed structure of the hydrogels. The adsorption capacity of SPIT and SPPIT for Pb2+ was 98.64 mg/g and 153.49 mg/g, respectively. Washing the Pb2+-loaded adsorbent with 10 °C deionized water, SPIT and SPPIT achieved a desorption efficiency of 94.59 % and 97.51 %, respectively. After 10 cycles of adsorption-desorption process, the adsorption capacity and desorption efficiency remained at about 80-88 % of the original ones, expressing excellent reusability. In a mixture containing eight metal ions (Pb2+, Cu2+, Mg2+, Ca2+, Cd2+, Na+, K+, Fe3+), the adsorption capacity of SPIT to Pb2+ was 92.