Kaplanfoster9752
istome is crucial to developing effective, robust, and reproducible interventions to control AMR. Video Abstract.
Research focuses heavily upon the effect of strength and power training on change of direction performance. The objective of this scoping review is to highlight alternative approaches to training change of direction.
Four databases (Scopus, PubMed, Web of Science and SPORTDiscus) were searched with no date restrictions. To be included studies must (i) investigate change of direction performance following an intervention or investigate the relationships between variables of interest and change of direction performance; (ii) recruit participants > 18years old; (iii) recruit participants involved in competitive sport. The majority of included studies investigated the effect of strength and/or power training, or, relationships between strength and/or power variables with change of direction performance.
Despite fewer studies, alternative training methods resulted in greater improvements (compared with strength and/or power) in change of direction performance, with smaller training durations. Few studies included reactive agility as an outcome measure.
Despite much of the literature focusing on strength and/or power, there are alternative training modalities that demonstrate merit for improving change of direction performance. Future studies should investigate the effect of alternative training interventions on reactive agility performance, to provide a more valid indication of transfer to competition.
Despite much of the literature focusing on strength and/or power, there are alternative training modalities that demonstrate merit for improving change of direction performance. Future studies should investigate the effect of alternative training interventions on reactive agility performance, to provide a more valid indication of transfer to competition.
This study investigated plasma biomarkers for neuroinflammation associated with Alzheimer's disease (AD) in subjects with preclinical AD compared to healthy elderly. How these biomarkers behave in patients with AD, compared to healthy elderly is well known, but determining these in subjects with preclinical AD is not and will add information related to the onset of AD. When found to be different in preclinical AD, these inflammatory biomarkers may be used to select preclinical AD subjects who are most likely to develop AD, to participate in clinical trials with new disease-modifying drugs.
Healthy elderly (n= 50; age 71.9; MMSE >24) and subjects with preclinical AD (n=50; age 73.4; MMSE >24) defined by CSF Aβ1-42 levels < 1000 pg/mL were included. Four neuroinflammatory biomarkers were determined in plasma, GFAP, YKL-40, MCP-1, and eotaxin-1. Differences in biomarker outcomes were compared using ANCOVA. Subject characteristics age, gender, and APOE ε4 status were reported per group and were covarthe Aβ misfolding and aggregation that is ongoing as indicated by the lowered Aβ1-42 levels in the CSF. Characterizing subjects with preclinical AD using neuroinflammatory biomarkers is important for subject selection in new disease-modifying clinical trials.
ISRCTN.org identifier ISRCTN79036545 (retrospectively registered).
ISRCTN.org identifier ISRCTN79036545 (retrospectively registered).
In diabetes, delayed wound healing was considered as the result of excessive recruitment and retention of pro-inflammatory cells and factors. Hematopoietic prostaglandin D synthase (HPGDS) was identified from differently expressed genes of diabetic human foot skin. HPGDS is responsible for the production of prostaglandin D2 (PGD2), an inflammatory mediator. Therefore, we aim to explore whether HPGDS could be a therapeutic target in the diabetic wound (DW).
In this study, we compared gene expression profilings of diabetic human foot skin and non-diabetic human foot skin from the Gene Expression Omnibus database. We detected the characteristics of immune components in diabetic mice wound and investigated the role and underlying mechanism of the differently expressed Hpgds for the diabetic wound healing. For in vivo studies, we engineered ADSC to overexpress Hpgds (ADSC
) and evaluated its effects on diabetic wound healing using a full-thickness skin wound model. For in vitro studies, we evaluated the role findings provide a new insight in the therapeutic strategy of diabetic wound.
3 × 3 basketball games are characterized by high-intensity accelerations and decelerations, and a high number of changes of direction and jumps. It is played in tournament form with multiple games per day. Therefore, optimal regeneration is crucial for maintaining a high performance level over the course of the tournament. AZD5438 To elucidate how load of a match affects the athletes' bodies (i.e., internal load), muscular responses to the load of 3 × 3 games were analyzed. We aimed to investigate changes in contractility of the m. rectus femoris (RF) and m. gastrocnemius medialis (GC) in response to the load of single 3 × 3 games and a 3 × 3 tournament.
Inertial movement analysis was conducted to capture game load in 3 × 3. Changes in contractility were measured using tensiomyography (TMG). During a two-day tournament, TMG measurements were conducted in the morning and after each game. Additionally, off-game performance analysis consisting of jump and change-of-direction (COD) tests was conducted the day before , it can therefore be concluded that the breaks between games seem to be sufficient to return to the initial level of muscle contractility.
The athletes' external 3 × 3 game load and their performance level did not seem to affect muscular contractility after a single 3 × 3 game or a complete 3 × 3 tournament within this investigation. This might indicate that elite athletes can resist external load without relevant local muscular fatigue. With respect to the course of the tournament, it can therefore be concluded that the breaks between games seem to be sufficient to return to the initial level of muscle contractility.
The loss of limbal stem cells owing to either corneal burn or inflammation leads to the repopulation of opaque skin over the raw surface of the cornea. It has been proposed that reconstitution of oral mucosal stem cells over this raw surface will mimic the limbal stem cells and restore vision. The efficacy and safety of applying a sheet of cultivated oral mucosal cells as an autologous graft for corneal replacement were evaluated.
The study was conducted during 2014-2015 and involved a total of six patients, of whom three had suffered a chemical burn and three had Stevens-Johnson Syndrome (SJS). Oral mucosal tissue was dissected from each patient, seeded onto irradiated J2 fibroblast feeder cells for 14 days, and analyzed for quality and safety 1 day before being transplanted onto the cornea of the affected eyes. After transplantation, topical antibiotic and anti-inflammatory eye drops were instilled four times daily, and the patients wore contact lenses. Subjects were clinically followed for visual acuitretrospectively 4 Apr 2015 ( https//clinicaltrials.gov/ct2/show/NCT02415218 ).
Long-term follow-up studies of adults with well-characterized asthma are sparse. We aimed to explore static lung volumes and diffusion capacity after 30 + years with asthma.
A total of 125 adults with an objectively verified diagnosis of asthma between 1974-1990 at a Danish respiratory outpatient clinic completed a follow-up visit 2017-19. All participants (age range 44-88years) completed a comprehensive workup and were, based on these assessments, classified as having either active asthma or being in complete remission. The examination program included measurements of static lung volumes and diffusion capacity.
Participants with active asthma were hyperinflated (residual volume/total lung capacity ratio 0.43, 95% CI 0.41-0.45) (RV/TLC ratio) compared with those in remission (RV/TLC ratio 0.38, 95% CI 0.36-0.41) (p < 0.03). A tendency towards higher diffusion capacity per liter lung volume was seen in participants with active asthma (KCO 100% predicted, 95% CI 97-104) compared with those in remission (KCO 94% pred., 95% CI 89-99) (P = 0.10). Longer asthma duration was associated with a higher KCO 0.47% pred./year (95% CI 0.14-0.80), adjusted for age and smoking. Patients on GINA step 4 and 5 treatment were more hyperinflated ([Formula see text] RV 14% pred., 95% CI 3-27) and had higher airway resistance (mean 53% pred., 95% CI 9-97) than participants on lower GINA steps. Patients with uncontrolled disease had substantially higher airway resistance (72% pred. 95% CI 20-124) than well-controlled patients.
Thirty years after a confirmed diagnosis of asthma, those continuing to have active asthma and those having severe asthma, have higher diffusion capacity and more hyperinflation than patients in remission.
Thirty years after a confirmed diagnosis of asthma, those continuing to have active asthma and those having severe asthma, have higher diffusion capacity and more hyperinflation than patients in remission.
The COVID-19 pandemic introduced a global need to explore the potential and challenges of online education.
To evaluate the presence of depression and anxiety in university students and their level of satisfaction with online learning during the period of social isolation caused by the COVID-19 pandemic.
A cross-sectional design was used to evaluate 152 online learning students from six different university courses Medicine, Psychology, Law, Engineering, Physiotherapy, and Business. The evaluation of the participants was carried out through an online survey in Rio de Janeiro, Brazil. Also, the Hospital Anxiety and Depression Scale was used to assess participants mental health.
Most of the participants reported emotional impact, followed by learning impact, financial impact, social impact, and technological impact, with a significant difference in the presence of depressive symptoms, but no significant difference in anxiety. The participants presented moderate anxiety levels, with no significant differences between genders, and mild levels of depressive symptoms with significant differences between genders. Also, younger students were more anxious than older students. In addition, female students with less social contact presented more depressive symtoms.
From a clinical perspective, the findings provide insights into mental health among university students during the COVID-19 pandemic. These findings may help in the development of effective screening strategies and in the formulation of interventions that improve the mental health of students.
From a clinical perspective, the findings provide insights into mental health among university students during the COVID-19 pandemic. These findings may help in the development of effective screening strategies and in the formulation of interventions that improve the mental health of students.
Little is known about the feasibility of progressive shoulder exercises (PSE) for patients with glenohumeral osteoarthritis (OA) or rotator cuff tear arthropathy (CTA). The aim of this study was to investigate whether 12 weeks of PSE is feasible in patients with glenohumeral OA or CTA eligible for shoulder arthroplasty. Moreover, to report changes in shoulder function and range of motion (ROM) following the exercise program.
Twenty patients were included. Eighteen patients (11 women, 15 with OA), mean age 70 years (range 57-80), performed 12 weeks of PSE with one weekly physiotherapist-supervised and two weekly home-based sessions. Feasibility was measured by dropout rate, adverse events, pain, and adherence to PSE. At baseline and end of intervention, patients completed the Western Ontario Osteoarthritis of the Shoulder (WOOS) score and Disabilities of the Arm, Shoulder and Hand (DASH). Data to assess feasibility were analyzed using descriptive statistics.
Two patients dropped out and no adverse events were observed.
