Franckneumann7716

To evaluate clinical and demographic characteristics and the results of cytotoxic treatments of



,



, and next-generation sequencing (NGS) panel negative patients.

NGS data of 1264 patients with non-small cell lung cancer were retrospectively evaluated. Among these patients, the mutation distributions of 1081 patients with metastatic lung adenocarcinoma were analyzed. A total of 150 patients with negative NGS panel or mutant

followed up in our clinic were included. Clinical features, overall survival, first-line chemotherapy responses, and progression-free survival of NGS panel negative,



, and



groups were compared.

In 1081 patients who underwent NGS from tumor tissue with the diagnosis of metastatic lung adenocarcinoma, 296 (27%) NGS panel negative and 276 (26%)

mutant patients were detected. Among these patients, 150 patients whose data were available were 71 (47.3%) NGS panel negative, 54 (36%)



, and 25 (16.7%)



. Clinical features, brain metastasis, and first-line chemotherapy response were similar among groups. Bone metastases were detected more often in the NGS panel negative group (

= 0.03). The median follow-up was 8.4 months. Overall, 107 deaths had occurred at the time of analysis. There was no difference in overall survival (

= 0.56) or progression-free survival (

= 0.71) among NGS panel negative,



, and



patients.

There is no difference in overall survival, first-line chemotherapy response, or progression-free survival among patients with NGS panel negative,



, or



metastatic lung adenocarcinoma. Bone metastases were observed more frequently in the NGS panel negative group.

There is no difference in overall survival, first-line chemotherapy response, or progression-free survival among patients with NGS panel negative, KRASG12C, or KRASother metastatic lung adenocarcinoma. Bone metastases were observed more frequently in the NGS panel negative group.This work aims to provide the first holistic and deep bibliometric mapping and analysis of the management of plastic waste. Data from the last five years were obtained from a Scopus database search. Z-YVAD-FMK purchase Relevant information on scientific production, contributions by country and institutions, sources, reference authors, and topic trends were obtained, being analysed using the VOSviewer and Bibliometrix R-package software programs. The results clearly have shown a significant increase in the number of publications over the years, depicting the great influence of the People's Republic of China, since the most relevant authors, publications, and institutes are Chinese. Regarding the topic trends, there is a massive concern about plastic pollution, especially related to plastic in water bodies (mainly microplastics), and the socio-environmental problems which plastic may cause/aggravate, with recycling and the circular economy emerging as possible solutions.The mass immigration of Ethiopian Jews to Israel began in the 1980s. For most of these immigrants this was a time of sharp transition from a village life with very basic living conditions, in most cases without a regular supply of water, electricity, or healthcare services, to a modern Western urban society. The aim of this review was to search the medical literature on the characteristics of infectious diseases that are typical in Ethiopian immigrants (EI), using relevant keywords. There has been success in coping with diseases among EI, that are rare although recognized in Israel, in terms of screening and early identification. TB was common in Ethiopia over all the years of immigration to Israel. In contrast, HIV appeared in EI from 1999 when they had long stayovers in transition camps in Gondar and Addis Ababa where there was a high risk of infection with sexually transmitted diseases. There were often delays in diagnosing 'exotic' diseases that are endemic in Africa, but not well known in Israel, such as Onchocerciasis, Schistosomiasis, Strongyloidiasis, and Bartonella endocarditis, which cause severe morbidity and mortality among EI. We describe the effect on general morbidity in Israel, and how the healthcare services coped with these diseases, including obstacles, and failures and successes. In light of the ongoing immigration of African refugees to the United States and Europe, the Israeli experience can be of value to healthcare policy makers in developing strategies for the effective management by medical staff treating these immigrants.1. The objective of this study was to determine the effects of two mixed LED light spectra on duck production, stress and fear responses. Pekin ducks were reared under either white/red (WR) or white/blue (WB) LED light.2. No differences were observed in feed conversion ratio (P = 0.690) or d 35 body weight (P = 0.919). Furthermore, no differences were observed in plasma interleukin-12 concentrations (P = 0.449), anti-keyhole limpet haemocyanin IgG titre (P = 0.503) or composite physical asymmetry score (P = 0.839). WR caused lower heterophil to lymphocyte ratios (0.40 ± 0.03, P = 0.029) and plasma corticosterone concentrations (4498 ± 534 pg/ml, P = 0.038) than WB (0.58 ± 0.08; 6518 ± 795 pg/ml, respectively). No differences were found in the number of attempts to induce tonic immobility (TI) or in inversion intensity. A shorter latency to first head movement during TI (9.44 ± 1.22 s, P = 0.06) and an overall shorter latency to right from TI (25.66 ± 2.99 s, P less then 0.001) was observed for birds under WR compared to WB (20.91 ± 6.01 s; 58.76 ± 8.86 s). The duration of time spent in the second stage of TI, where birds observed their environment using head movements while still remaining immobile on their backs, was shorter in WR (16.23 ± 1.73 s, P = 0.001) compared to WB (37.85 ± 6.38 s).3. The results indicated that rearing ducks under WR caused less stress susceptibility and fear responses compared to ducks under WB. Pekin duck welfare may be compromised by blue LED light exposure, even at supplemental levels utilised in commercial poultry lighting.1. Uniformity in animal products is an important aspect of the production system. Several studies have reported estimates of genetics on residual variance in different species, indicating that it could be exploited to improve uniformity by selection. Nevertheless, there are no reports about the possibilities of such a selection strategy in meat quail.2. Records of hatching weight (HW) and body weight at 42 days (W42) of female and male birds from two meat quail lines (UFV1 and UFV2) were analysed. A three-step genetic evaluation was used to investigate the effect of genetic variation on residual variance of HW and W42 in both lines. In Step 1, a single-trait model was fitted to the data. In Step 2, log-transformed squared estimated residuals (ln(ê2)) were evaluated for these traits. In Step 3, a multi-trait analysis was performed to estimate the genetic correlation between the additive genetic effects for HW, W42, and their respective ln(ê2).3. The heritability estimates ranged from 0.12 to 0.23 for HW and from 0.22 to 0.35 for W42. The estimated heritabilities for the residual part were low and ranged from 0.0003 to 0.02 for both traits, and the genetic coefficient of variation residual variance estimates ranged from 0.31 to 0.42 for HW and from 0.09 to 0.25 for W42. Genetic correlations between the means (HW and W42) and ln(ê2) values were both positive and did not differ from zero, indicating no association between mean and ln(ê2).4. In conclusion, the uniformity of HW and W42 could be improved by selecting for lower residual variance in both meat quail lines, but the accuracy of selection may be low due to low heritability for uniformity, mainly for W42.

We examined cancer survivor worries about treatment, infection, and finances early in the U.S. COVID-19 pandemic.

Closed- and open-ended online survey questions were collected from adult cancer survivors (N = 972).

Logistic regression identified factors associated with treatment, infection, and financial worry. Thematic qualitative analysis generated information around participants' experiences and worries related to COVID-19 and healthcare.

Characteristics including marital status, race/ethnicity, cancer type, time since last treatment, education, and age were associated with health and healthcare worry outcomes. Survivors commonly expressed uncertainty about future care, fears about in-person appointments, rationed COVID-19 care, recurrence due to care delays, and distress about untreated symptoms, including mental health issues.

Early in the pandemic, survivors worried about and experienced cancer care delays, COVID infection, and how the pandemic would affect their prognosis.

Healthcare professionals need to be aware of cancer survivors' concerns and uncertainties to provide appropriate care.

Healthcare professionals need to be aware of cancer survivors' concerns and uncertainties to provide appropriate care.We aimed to compare the efficacy of two different starting doses of recombinant follicle stimulating hormone (rFSH), 37.5 vs. 75 international units (IU) for intrauterine insemination (IUI) cycles in non-obese women with polycystic ovary syndrome (PCOS). A total of 109 women who underwent first rFSH stimulated IUI cycle were included in this retrospective cohort study. The primary outcome measure was the clinical pregnancy rate. No significant difference was found in terms of clinical pregnancy rate between the two groups (22% for the 37.5-IU group and 24% for the 75-IU group, respectively, p = .808). There was no significant difference in monofollicular development rate among the groups (p = .354). The total rFSH consumption was lower in the 37.5-IU group compared to the 75-IU group (p less then .001). There was no statistically significant difference in pregnancy rates between the 37.5-IU and 75-IU groups in both normal weight (BMI 19-24.9 kg/m2) and overweight (BMI 25-29.9 kg/m2) women (p = .889 and .518, respectively). These results suggest that the starting doses of 37.5 and 75 IU of rFSH do not show significant difference in clinical pregnancy rates in non-obese PCOS women undergoing IUI cycles.Impact StatementWhat is already known on this subject? Low-dose gonadotropin treatment is advised for women with polycystic ovary syndrome (PCOS). However, there are few comparative data on the efficacy of different starting doses of recombinant follicle stimulating hormone (rFSH) for intrauterine insemination (IUI) cycles in PCOS women.What the results of this study add? There was no statistically significant difference in pregnancy rates of non-obese patients with PCOS having IUI whether rFSH was started at 37.5 or 75 international units (IU).What the implications are of these findings for clinical practice and/or further research? A starting dose of 37.5 IU of rFSH may be a reasonable approach for IUI cycles in non-obese PCOS women.Two new compounds, an isoquinoline (1) and caloneuramide (2), a ceramide were isolated from the stem bark of Discoglypremna caloneura together with seven known compounds namely aurantiamide acetate (3), acetylaleuritolic acid (4), 3α-hydroxylaleuritolic acid 2α-p-hydroxybenzoate (5), mixture of stigmasterol (6) and β-sitosterol (7), mixture of 7-oxo-stigmasterol (8) and 7-oxo-β-sitosterol (9). Their structures were determined based on data from literature and spectroscopic methods. Derivatization reactions on the isoquinoline led to two new compounds, the methylated (10) and acetylated (11) derivatives. Some compounds and extracts were evaluated for their cytotoxic and antiproteinase activity. Antiproteinase effect of compounds 1, 10 and 11 exhibited IC50 values of 10.77, 1.19 and 3.61 μg/mL respectively; significantly low compared to the standard drug, acetyl salicylic acid (IC50 = 20.28 μg/mL). Ethyl acetate and methanol extract exhibited moderate cytotoxicity activity on Chang liver cells with CC50 values of 167.