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This study paves the way for the rational design of MOFs-based heterostructures towards efficient electrocatalytic oxygen evolution.Functional surfaces and coatings with excellent anticorrosion performances are of great significance for numerous engineering applications. However, developing waterborne coatings with long-term anticorrosion properties remains challenging. In this study, we developed a multifunctional nanocontainer for a waterborne coating matrix, using zeolitic imidazolate framework (ZIF)-derived layered double hydroxides (LDHs) as the gatekeepers for benzotriazole (BTA)-encapsulated mesoporous silica nanoparticles (MSNs-BTA). The LDHs outer layer and the ZIF intermediate layer endowed the MSNs-BTA@ZIF-LDHs nanocontainer with excellent compatibility, dispersion, and pH-responsive controllable release properties in the waterborne coating matrix. The waterborne epoxy composite coatings showed excellent passive and active anticorrosion performances, well-characterized by electrochemical impedance spectroscopy (EIS), permeation experiments, neutral salt spray (NSS) tests, and the scanning vibrating electrode technique (SVET). This excellent corrosion protection performance can be attributed to two factors before corrosion, the MSNs-BTA@ZIF-LDHs served as passive nanofillers against corrosive media, significantly improving the barrier properties of the composite coatings; after the occurrence of corrosion, the MSNs-BTA@ZIF-LDHs acted as pH-responsive nanocontainers and released pre-loaded BTA corrosion inhibitors, preventing further damage to the exposed metal substrate. This study provides new insights into the development of multifunctional anticorrosion surfaces and coatings for various engineering applications.

Endometriosis is an estrogen-dependent disease characterized by the presence of endometriotic tissue outside the uterine cavity, the condition that immunological factors play important roles in its pathogenesis. Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine that triggers dendritic cell-mediated T helper2 inflammatory responses. TSLP receptor, or cytokine receptor- like factor 2 (CRLF2), forms a functional heterodimeric complex with IL-7 receptor alpha (IL-7Rα) to bind with TSLP. The present study aimed to elucidate the expression and epigenetic alterations of TSLP gene parallel to TSLP receptor and IL-10 genes expression in endometrial tissues of patients with endometriosis compared to controls.

In this case-control study, 45 women with and without endometriosis was enrolled. The relative expression of TSLP, TSLPR and IL-10 genes were examined using qPCR. Chromatin Immunoprecipitation (ChIP) was also used to monitor epigenetic marks of methylation and acetylation on lysine 9 of hisigenetic changes were aligned with TSLP gene expression profile. These data collectively identify TSLP and TSLPR as candidate genes critically involved in development of endometriosis beyond their role in promoting Th2 immune responses. In addition, acetylation and methylation of H3K9 may have effective roles in TSLP dysregulation in endometriosis.Two experiments were undertaken to examine the spontaneous and intentional formation of interpersonal coordination patterns within dyads. In both experiments, each individual in a dyad was given a pre-set amplitude goal of tracing a 3 cm or 15 cm line to maintain over a trial. Smaller amplitudes were associated with faster movement frequencies compared to larger amplitudes in both experiments. All trials started with the partners in the dyads not seeing each other, and at the half-way point within a trial vision of the partner was provided. In experiment 1, each individual was told to watch their partners hand in the view segment, yet maintain the amplitude goal. The pre-set amplitude goals limited the emergence of spontaneous interpersonal coordination in the form of frequency-locking and phase-entrainment. In experiment 2, the individuals in the dyad were told to intentionally coordinate at either a defined in-phase or anti-phase pattern of coordination when entering the view segment of a trial. All dyads formed the required coordination patterns at a 11 frequency-locking across 90% of trials when entering the view segment. However, the pre-set amplitudes still influenced performance of individuals in terms of movement amplitude and frequency modulations when intentionally forming the required coordination patterns. The proposed hypotheses and the interpretation of the results are framed within the coordination dynamics theory of perception-action processes.When viewing objects depicted in a frame, observers prefer to view large objects like cars in larger sizes and smaller objects like cups in smaller sizes. That is, the visual size of an object that "looks best" is linked to its typical physical size in the world. Why is this the case? One intuitive possibility is that these preferences are driven by semantic knowledge For example, when we recognize a sofa, we access our knowledge about its real-world size, and this influences what size we prefer to view the sofa within a frame. However, might visual processing play a role in this phenomenon-that is, do visual features that are related to big and small objects look better at big and small visual sizes, respectively, even when observers do not have explicit access to semantic knowledge about the objects? To test this possibility, we used "texform" images, which are synthesized versions of recognizable objects, which critically retain local perceptual texture and coarse contour information, but are no longer explicitly recognizable. To test for visual size preferences, we first used a size adjustment task, and the results were equivocal. However, clear results were obtained using a two-interval forced choice task, in which each texform was presented at the preferred visual size of its corresponding original image, and a visual size slightly bigger or smaller. Observers consistently selected the texform presented at the canonical visual size as the more aesthetically pleasing one. An additional control experiment ruled out alternative explanations related to size priming effects. These results suggest that the preferred visual size of an object depends not only on explicit knowledge of its real-world size, but also can be evoked by mid-level visual features that systematically covary with an object's real-world size.Traumatic brain injury can have devastating consequences for patients and extended hospital stays and recovery course. Recent data indicate that the initial insult causes profound changes to the immune system and leads to a pro-inflammatory state. This alteration in homeostasis predisposes patients to an increased risk of infection and underlying autoimmune conditions. Increased emphasis has been placed on understanding this process both in the clinical and preclinical literature. This review highlights the intrinsic inflammatory conditions that can occur within the initial hospital stay, discusses long-term immune consequences, highlights emerging treatment options, and delves into important pathways currently being investigated with preclinical models.The present work investigated Hastatella radians Erlanger, 1890 (type species), and H. aesculacantha Jarocki & Jakubowska, 1927, isolated from Chongming Island, Shanghai, China, based on light microscopy observations of live individuals, silver staining and molecular phylogeny methods. Hastatella radians is characterized by its size (about 30-75 μm long, 25-70 μm wide), two girdles of ectoplasmic processes, infundibular polykinety 3 (P3) composed of two rows of unequal length and terminating beyond adstomal end of P2, 8-22 transverse silverlines between peristome and trochal band, and 5-9 between trochal band and scopula. The infraciliature of H. aesculacantha is described for the first time, and we improved its diagnosis cell size about 25-52 × 20-41 μm in vivo; four girdles of ectoplasmic processes; P3 two-rowed, outer row much shorter than inner one; 5-7 silverlines between peristome and trochal band and four or five between trochal band and scopula. Phylogenetic analyses based on SSU rDNA sequences revealed that Hastatella is monophyletic and has a close relationship to Astylozoon enriquesi.The association of body fluids/cell types and donors in mixed biological traces is an important, but challenging task required to evaluate the value of evidence given forensic propositions concerning the source of the DNA. The linking of a DNA profile with evidence from presumptive tests or RNA analysis is not straightforward. Coding region SNPs (cSNPs) are a novel type of evidential markers that are both cell type specific and individual specific. They thereby provide a direct link between a donor and a body fluid in mixed biological stains. In this proof-of-concept paper we consider the evaluation of cSNP profiles given source level propositions and explore the use of the open-source software EuroForMix to compute likelihood ratios. The discrimination power of the cSNPs for various body fluids is investigated with simulations. We provide case examples where the type of biological material is questioned and where cSNP profiles can be used to assign a donor to a body fluid, and discuss how the results can be reported in court.The North American cheetah (Acinonyx jubatus) population serves as both an insurance population for their rapidly decreasing wild cohorts as well as a research population to understand the unique biology of this species. This review focus on the complexity of the female cheetah reproductive system and the recent advances that have been made towards understanding basic biology and reproductive function, and application of assisted breeding technologies to enhance reproduction and maintain genetic diversity of this species in human care. Cheetah females are non-seasonal breeders that exhibit lengthy periods of anestrus that are not associated with age, environment, or reproductive potential. It is possible to collect good quality oocytes, that support fertilisation and successful early embryonic development, regardless of female age (from 2 to 12 yr old). MS1943 However, the prevalence of uterine pathologies increases with age and prevents middle to advanced age females from establishing pregnancy. Pregnancy can be diagnosed in non-sedated cheetah females via ultrasonography (first month), steroid hormone analysis (second/third month) or radiography (third month). Fecal biomarkers, such as Immunoglobulin J, show great promise for diagnosing pregnancy at an early stage as well as other physiological states. Several decades of basic research have led to efficient management of natural breeding and recent successes in assisted reproduction.Personal goals are important for the construction and organization of episodic future thought. This study examines the impact of two future thinking perspectives on qualities of mental goal representations. Here, 142 participants (Mage = 21.9 years) reported on the content and characteristics of five life goals either retrospectively, imagining goals from the perspective of their 100-year-old self, or prospectively from the perspective of their current self. Results indicate that retrospectively reported life goals relied more on schematized knowledge, were dated to occur later in life, and were perceived as more self-concordant with increasing distance from the present. Independent of condition, more distant goals were rated as more difficult, less likely to occur, and were associated with lower self-efficacy. This study provides the first evidence that the point in life from which you consider your own future affects the qualities of mental goal representations, suggesting that retrospective future thinking serves as a form of psychological distancing.