Uptonlandry3298

Optimal constructs of oligosaccharides from the epidemiologically significant pneumococcal serotypes are presented that can be used for designing synthetic pneumococcal vaccines, as well as test systems for diagnosis of S. pneumoniae infections and monitoring of vaccination efficiency .Communication with family members about sex can protect teens from risky sexual behavior, but most research focuses on teens' communication with parents. Extended family members may also be a source of sexual socialization to support teens' health, but teens' perspectives on communication with extended family about sex have been little explored. The current study aims were to examine similarities and differences in the frequency and content of teens' communication with extended family and parents about sex and to assess whether the content of this communication differs based on teens' gender. This cross-sectional study used structural equation models (SEM) to analyze survey data from 952 11th and 12th graders (55% Female, 52% Latinx) in the United States. The study assessed three types of family talk about sex Communication about Risks of Sex addresses negative consequences of sex, communication about Protection involves ways teens can guard against pregnancy and sexually transmitted infections and Relational Sex communication addresses sex within the context of a close relationship. We found that teens were as likely to report talk with extended family members as parents about sex. Teens' conversations with parents were more focused on sexual risk and protection while conversations with extended family focused on relational sex topics. Girls were more likely to engage in protection and relational sex communication with extended family, while boys talked more often with parents about these topics. These findings highlight the potential of extended family to support teens' healthy development.Despite high rates of intimate partner violence (IPV) among teens who are pregnant or parenting, the field is lacking evidence-based prevention programs designed for this population. The purpose of this study was to comprehensively adapt the evidence-based Safe Dates IPV prevention program and conduct a pilot study of the adapted program with female teens who were pregnant or parenting. We completed formative research including a literature review, focus groups, and pre-testing of adapted content to inform the revised curriculum. We then conducted a randomized controlled trial with 32 teens (average age = 17) to compare the adapted program to the original program on implementation characteristics and outcomes, including IPV perpetration and victimization. Directions of effect favored the adapted program over the original program for 18 out of 21 implementation outcomes for which models could be estimated and for 11 of 12 participant outcomes. The strongest effects, all favoring the adapted program, were found for observer-reported adherence to the curriculum, participant ratings of the relevance of characters and scenarios, participant knowledge of ways to get help for abuse, and attitudes toward IPV. These findings demonstrate the feasibility and acceptability of the adapted program for this target population and suggest that the program may be efficacious when evaluated in a larger study.In this study we tested, via a randomized control study design, different enrollment options for a scaled city-wide text-based early learning program among 405 mothers who were receiving newborn home visiting services. We found that when automatically enrolled with a voluntary option to opt out, 88.7 percent of mothers in the experimental group stayed in the program and continued to receive the text-based content over the course of 26 weeks. In contrast, only 1 percent of mothers in the control group who heard about the text-based program through conventional recruitment flyers voluntarily enrolled in the program. Opt-out and opt-in patterns did not differ by characteristics typically considered as interfering with program participation low income status, first-time motherhood status, total number of children, maternal language, flagging for depressive symptoms, and household residential instability. Findings suggest that automatic enrollment might be an effective engagement strategy for text- and similar digitally-based early childhood programs.This study evaluated how patterns of mothers' depressive symptoms across their child's childhood relate to children's psychosocial adjustment at adolescence and young adulthood and to cognitive functioning at adolescence. Depressive symptoms were measured in 1,273 mothers when their children were 1, 5, 10, and 14.6 years of age. Children (53.5% male; n = 1,024) completed the Youth Self-Report at adolescence (M = 14.6y), and the Adult Self-Report in young adulthood (M = 20.5y; n = 817) to assess internalizing and externalizing symptoms. Adolescents also completed standardized cognitive tests to assess verbal and mathematical skills. Growth mixture modeling analyses identified four patterns of maternal depressive symptom trajectories infrequent (55%), increasing at adolescence (20%), decreasing at adolescence (14%), and chronic severe (11%). Results indicated that exposure to maternal depression of any duration, severity or time period during childhood portended higher levels of externalizing and attention problems at both adolescence and adulthood and higher levels of internalizing problems at adulthood. Adolescents whose mothers had chronic severe depressive symptoms had lower language, vocabulary, reading comprehension and mathematical test scores than youth whose mothers had stable infrequent depressive symptoms. find more Findings illustrate the significance and long-term ramifications of mothers' depressed mood for their children's mental and psychosocial health into adulthood. Findings also demonstrate that the lower cognitive abilities among children of severely depressed mothers persist beyond childhood and pertain to a broad range of cognitive abilities.Black female primary caregivers who receive Temporary Assistance for Needy Families (TANF) are burdened not only by economic pressure but also by a disproportionate prevalence of psychological disorders. This is particularly pernicious given that poverty and maternal mental health impact child outcomes and may decrease the economic mobility of families. Consequently, it is imperative to understand the mechanisms that explain the association between economic pressure and child outcomes. The current study addressed this gap by testing an application of the Family Stress Model (FSM), which describes how economic pressure results in parental psychological distress, particularly depression, and in turn impacts parenting quality and child outcomes. Additionally, social support was assessed as a potential culturally-salient protective factor within the model. Four hundred sixteen Black female primary caregivers who receive TANF were administered a series of measures assessing mental health and family wellbeing. Structural equation modeling was utilized to test a single model that incorporated all hypotheses.