Herndonmelendez6532
Hepatic lipid accumulation is an initiation factor in fatty liver disease, and promoting a reduction in hepatic lipid accumulation is an important treatment strategy. DEAD box RNA helicase 17 (DDX17) is a member of the DEAD-box family and a molecular chaperone. Previous studies have demonstrated that DDX17 is a transcriptional coregulator of tumorigenesis, inflammation, and macrophage cholesterol efflux. The liver is the main site for lipid metabolism, and metabolic (dysfunction)-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases. However, the impact of DDX17 on hepatic lipid accumulation has not been verified. In this study, we found, for the first time, that oleic acid/palmitic acid (OA/PA)-induced lipid accumulation was largely abrogated by DDX17 overexpression in both HepG2 (a human hepatocellular carcinoma line) and Hep1-6 (a murine hepatocellular carcinoma line) cells, and this effect was due to a marked reduction in cellular triglyceride (TG) content. Moreover, the overexpression of DDX17 was accompanied by a significant decrease in the expression of genes involved in de novo fatty acid synthesis (FAS, ACC, and SCD-1) in both HepG2 and Hep1-6 cells. In conclusion, DDX17 protected against OA/PA-induced lipid accumulation in hepatocytes through de novo lipogenesis inhibition.
One of the highlighted properties of Ti
C
T
MXene compared to other 2D nanomaterials is its hydrophilicity. However, the broad range of static contact angles of Ti
C
T
reported in the literature is misleading. To elucidate the experimental values of the static contact angles and get reproducible contact angle data, it is wiser to perform the advancing and receding contact angle measurements on smooth and compact Ti
C
T
layers and focus on deep understanding of the physical basis behind the wettability, which is provided by contact angle hysteresis.
Measurements of the advancing and receding contact angle on mono-, bi, and trilayer Ti
C
T
on two different substrates were performed. As substrates, UV-ozone treated silicon wafer and silicon wafer functionalized by (3-aminopropyl)triethoxysilane, were used.
The values of the advancing contact angle on Ti
C
T
on both substrates were proved to be independent of the number of Ti
C
T
layers, demonstrating a negligible effect of the background substrate wettability. In addition, a giant contact angle hysteresis (44-52 °) was observed on very smooth surface, most likely as a result of chemical heterogeneity arising from the diversity of surface terminal groups (F, O, and OH). The findings reported in this study provide a comprehensive understanding of the wettability of MXene.
The values of the advancing contact angle on Ti3C2Tx on both substrates were proved to be independent of the number of Ti3C2Tx layers, demonstrating a negligible effect of the background substrate wettability. In addition, a giant contact angle hysteresis (44-52 °) was observed on very smooth surface, most likely as a result of chemical heterogeneity arising from the diversity of surface terminal groups (F, O, and OH). The findings reported in this study provide a comprehensive understanding of the wettability of MXene.Antimony (Sb) has attracted considerable attention as an anode material for potassium ion batteries (PIBs) because of its high theoretical capacity. Nevertheless, owing to the large radius of K+, apparent volume expansion occurs during the reaction between Sb and K+, which will undermine the stability of the electrode. Accordingly, a dual-carbon confinement strategy is regarded as an effective method for handling this issue. Herein, Sb is firstly captured by mesoporous carbon sphere (MCS) to form a composite of Sb/MCS, and then reduced graphene oxide (rGO) is adopted as an outer layer to wrap the Sb/MCS to obtain the dual-carbon confinement material (Sb/MCS@rGO). Given the synergistic confinement effects of the MCS and rGO, the Sb/MCS@rGO electrode realizes an excellent rate capacity of 341.9 mAh g-1 at 1000 mA g-1 and prominent cycling stability with around 100% retention at 50 mA g-1 after 100 cycles. Besides, the discussion on galvanostatic charge-discharge test, cyclic voltammetry and ex-situ XRD illustrates the stepwise potassium storage mechanism of Sb. Benefiting from the dual-carbon confinement effects, the Sb/MCS@rGO electrode processes promising electrochemical reaction kinetics. Furthermore, the application of the Sb/MCS@rGO in full cells also demonstrates its superior rate capacity (212.3 mAh g-1 at 1000 mA g-1).Excessive conductivity of carbon-based materials led to poor impedance matching, hindering their electromagnetic absorbing application in aerospace and military fields. While, one-dimensional carbon materials are more favorable to build networks, satisfying impedance matching. One-dimensional carbon materials, such as carbon fibers, carbon nanotubes, carbon microtubes, etc., are recently limited by strict preparation and hard to industrialize. Inspired by the traditional handicraft of candied haw, ZnO/porous carbon micron tubes (ZnO/PCMT), are achieved by conducting a dip-coating and thermal etching process on recycling the abandoned Sycamore microtube. The prepared ZnO/PCMT exhibits higher specific surface area (1076m2g-1) and excellent microwave absorption performance. With a filler loading of only 6.7wt.%, the ZnO/PCMT achieved a great electromagnetic wave absorbing performance. Such excellent ultralight absorption performance can be attributed to their distinct hollow tubular structure of Sycamore based carbon microtube, which can easily construct conductive networks, improving the impedance matching. This work expands a new direction for the development of one-dimensional natural Sycamore microtube as ultra-light and broadband high-performance microwave absorbing materials.The fundamental mechanistic understanding of the working principle of metal phthalocyanine (MPc) + H2O2 system, at molecular level, is in its nascent stage. In this paper, a green strategy was employed for the immobilization of sulfonated cobalt phthalocyanine (CoPc) onto reduced graphene with assistance of bio-synthesized nanocellulose, and the resulting graphene-supported-CoPc (CoPc&G) was applied for the catalytic degradation of phenol solution with H2O2 as oxidant. More than 90% of phenol can be removed within 75 min, and the existence of graphene clearly has a positive effect on the catalytic activity. Theoretical calculations were conducted to unveil the catalytic nature of CoPc&G. H2O2 was favorably chemisorbed onto CoPc&G in the form of OOH-, hydroxyl radicals were favorably formed by homolytic cleavage of OO bonds, and ΔG value for the formation of reactive species was decreased with the existence of graphene. Fludarabine research buy Density of states (DOS) analysis shows that graphene could effectively boost the electronic activity, reduce HOMO-LUMO gap, and strengthen the polarizability of the catalyst, thereby lower the free energy gap for the enhanced generation of reactive species. A detailed catalytic degradation route of phenol with CoPc&G + H2O2 system was established based on the combination of theoretical calculations and experimental results.In this work we study the electro-orientation (through electric birefringence experiments) of silver nanowires in polymer solutions eventually capable of forming gel networks. Information on the structure of the polymer solution is obtained by evaluating the electro-orientation of the nanowires. It is found that in presence of poly(ethylene oxide), Kerr's law (birefringence proportional to the square of the field) is fulfilled, and the randomization process after switching off the external field is purely diffusive, controlled by the viscosity of the Newtonian polymer solution. In the case of (gelating) sodium alginate solutions, measuring at larger distances from the bottom (where the source of cross-linking Ca2+ ions is deposited) means a smaller degree of cross-linking, and a less stiff gel. In fact, it is found that after a certain time the birefringence signal gets frozen at the bottom, indicating that a gel network is formed which hinders particle orientation. The viscosity deduced up to that point agrees well with rheological determinations, with increasing deviations found at longer times due to the inhomogeneous gel formation. This process has an interesting consequence on birefringence response Kerr's law fails to be fulfilled, appearing a "yield" applied electric field, larger the longer the time after preparation.The slow conversion of Fe(Ⅱ)/Fe(III) cycle was largely limited the degradation efficiency of many photo-Fenton systems. Herein, four Fe-MOFs nanorods (namely Fe-TCPP-1, Fe-TCPP-2, Fe-TCPP-3, Fe-TCPP-4) with decreasing length-diameter ratios were synthesized in a household microwave oven, using photosensitizer porphyrin and iron ions with Fenton activity as building blocks. Among them, the Fe-TCPP-3 exhibited high photogenerated electron-hole (e--h+) separation efficiency and largest pore structure, endowing Fe-TCPP-3 with superior photo-Fenton property. In addition, Fe-TCPP-3 based photo-Fenton system was applied to efficiently degrade antibiotic ciprofloxacin (CIP) under neutral condition, due to the continuously generated reactive species (h+, e-, OH·, O2·-, 1O2) in Fe-TCPP-3 under visible-light irradiation. With irradiation for 30 min, the degradation efficiency of the system could reach about 73 %, which was about 26-fold towards the system without light irradiation. This study paved a way to modulating the photo-Fenton activity of MOF-based catalysts.Polymeric carbon nitride (CN) has evoked considerable attention in photocatalysis, however, its π-deficiency conjugated frameworks engendering weak visible-light absorption and rapid charge recombination hinder the practical utilizations. Herein, a novel donor-acceptor (D-A) conjugated polymer based on triptycene incorporated carbon nitride (T-CN) has been facilely prepared by thermal copolymerization of melamine and 2,6,14-triaminotriptycene. Combined with the density functional theory (DFT) calculations, it is found that the formation of intramolecular charge transfer and the extended π-conjugative effect in the D-A structure contribute to a broadened light-harvesting spectral range, a higher charge separation/transfer efficiency and more active sites of T-CN for photoredox reactions. The T-CN catalyst accomplished superior visible-light photocatalytic performance in both hydrogen evolving and carbon dioxide reduction. The optimal T-CN catalyst exhibited the highest hydrogen evolution rate of 80.9 ± 1.3 μmol·h-1 and carbon monoxide production rate of 8.1 ± 0.2 μmol·h-1, which are ca. 8-fold and 20-fold of bulk CN, respectively. The convenient strategy of constructing D-A conjugated structure opens up a new intriguing avenue toward the rational creation of efficient polymeric nanomaterials for versatile applications of solar fuel production.Recently, g-C3N4 (CN) loaded N-doped carbon dots (NCDs) have been widely studied as promising metal-free photocatalysts due to their impressive performance in hydrogen production. However, deep understanding of the effect of nitrogen chemical states on photocatalytic activity is still lacked. In this work, NCDs doped with pyrrole nitrogen, graphite/pyrrole nitrogen, and pyrrole/pyridine nitrogen were prepared and hybridized with g-C3N4. The characterizations revealed that, incorporation of pyrrole N-doped CDs into g-C3N4 (CN/NCDs-en) effectively enhanced the visible light absorption, facilitated electron-hole separation, and promoted the participation of photoexcited electrons in H2 evolution reaction. Moreover, theoretical calculation showed that, compared with graphite N and pyridine N, pyrrole N has the most appropriate H adsorption ability, which is conducive to the H2 formation. Under visible light irradiation, the CN/NCDs-en exhibited the best hydrogen evolution of 3028 μmol h-1 g-1. These results shed a light on the design and optimization of N-doped metal-free photocatalysts for H2 evolution reaction.
