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8% (ΔR2 = .32, p less then .001). Self-control did not predict consumption, and no interaction effects were found on the intention-behaviour relationship.Conclusion Reflective and automatic processes were both important predictors of consumption. Intention, habit, and environmental cues may be suitable intervention targets to reduce consumption.Objectives Yttrium-90 transarterial radioembolization (TARE) is a safe, effective modality of locoregional therapy for intermediate and advanced-stage hepatocellular carcinoma (HCC). We aim to identify novel predictors of important outcomes of TARE therapy. Methods A single-center retrospective study of 166 patients treated with TARE for HCC at Mayo Clinic Rochester between 2005-2015 and followed until December 2017. Multivariate logistic and stepwise regression analysis models were used to identify variables associated with overall survival (OS) and progression-free survival (PFS). Results The median OS and the median PFS were12.9 (95% CI 11.0-17.3), and 8 months (95% CI 6-11), respectively. Macrovascular invasion (HR 1.9 [1.3-2.8]), Child-Pugh score (CPS) B or C vs. A (HR 1.8 [1.2-2.7]), Eastern Cooperative Oncology Group Performance status (ECOG-PS) 2 or 1 vs. 0 (HR 1.6 [1.1-2.4]) and activity (A) of administered radiation dose (HR 1.005[1.00-1.010), independently correlated with poorer OS. Infiltrative HCC (HR 2.4 [1.3-4.5), macrovascular invasion (HR 1.6 [1.1-2.7]), and high activity of administered radiation dose (HR 1.005 [1.00-1.010) were associated with worse PFS. Conclusion In HCC patients treated with TARE; macrovascular invasion, the activity of radiation dose, CPS, ECOG-PS, and infiltrative HCC predict OS and PFS.Background - Brugada syndrome (BrS) is an oligogenic arrhythmic disease with increased risk of sudden cardiac arrest (SCA). Several BrS or ECG traits-related single nucleotide polymorphisms (SNPs) were identified through previous genome-wide association studies in Caucasian patients. We aimed to validate these SNPs in BrS patients in the Taiwanese population, assessing the cumulative effect of risk alleles and the BrS polygenic risk score (BrS-PRS) in predicting cardiac events. Methods - We genotyped 190 unrelated BrS patients using the TWB Array, and Taiwan Biobank was used as controls. SNPs not included in the array were imputed by IMPUTE2. Cox's proportional hazards model was utilized to evaluate the associations between each particular SNP, the collective BrS-PRS, and clinical outcomes. Results - Of the 88 previously reported SNPs, 22 were validated in Taiwanese BrS patients (P less then 0.05). Of the 22 SNPs, 2 (rs10428132, rs9388451) were linked with susceptibility to BrS, 10 were SNPs previously reaching genome-wide significance, and 10 were SNPs associated with electrocardiogram traits. For the 3 most commonly reported SNPs, disease risk increased consistently with the number of risk alleles (OR 3.54, Ptrend = 1.38 * 10-9 for 5 risk alleles versus 1). Similar patterns were observed in both SCN5A mutation+ (OR 3.66, Ptrend = 0.049) and SCN5A mutation- (OR 3.75, Ptrend = 8.54 * 10-9) subgroups. Furthermore, BrS patients without SCN5A mutations had more risk alleles than BrS patients with SCN5A mutations regardless of the range of PRS. Three SNPs (rs4687718, rs7784776, rs2968863) showed significant associations with the composite outcome (SCA plus syncope, HR 2.13, 1.48, 0.41; P=0.02, 0.006, 0.008, respectively). Conclusions - Our findings suggested that some SNPs associated with BrS or electrocardiogram traits exist across multiple populations. The cumulative risk of the BrS-related SNPs is similar to that in Caucasian BrS patients, but it appears to correlate with the absence of SCN5A mutations.The world has been under the negative effect of the COVID-19 pandemic for the last few months. While people may take many preventive behaviours to minimize the risk, very little is known about the factors that can increase preventive behaviours during the COVID-19 pandemic. This study examined the effects of vulnerability, perceived risk, and fear on preventive behaviours of COVID-19. The study used a sample of 4,536 Turkish adults (M = 30.33 ± 10.95 years) recruited from 17 March through 1 April 2020. Vulnerability, perceived risk, fear, and preventive behaviours were measured with self-rating scales. Participants mostly engaged in avoidance of public transportation and frequent handwashing as preventive behaviours. Women had a significantly higher vulnerability to, perceived risk, and fear of new coronavirus compared to men. Correlation results indicated that age, gender, education level, vulnerability, perceived risk, and fear were related to preventive behaviours. Regression results demonstrated that vulnerability, perceived risk, and fear accounted for a significant amount of variance in preventive behaviours over and above the effects of demographic variables. Cyclopamine price The results suggest that vulnerability, perceived risk, and fear can significantly increase engagement in preventive behaviours during the novel coronavirus pandemic. The results have important implications for research and practice.Aim Establishing an optimal diagnostic policy for patients with respiratory tract infections, at the emergency department (ED) of a university hospital in The Netherlands. Methods Adult patients were sampled at admission, during the respiratory season (2014-2015). The FilmArray-RP was implemented at the clinical virology laboratory. Diagnostics were provided from 8 am to 10 pm, weekends included. Results 436/492 (89%) results were available while patients were still at the ED. Median TAT from admission to test result was 165 min (IQR138-214). No antibiotics were prescribed in 94/207 (45%) patients who tested positive for a virus. 185/330 (56%) hospitalized patients did not need admission with isolation measures. The value-based measure, expressed in euro-hour (€hr), increased to tenfold compared with previous policy. Conclusion An optimal policy is essential for patient management, by providing timely, reliable diagnostics.To explore the influence of sexuality-related factors on recent two-week morbidity and annual hospitalization in female migrant workers, 880 Chinese rural-to-urban female migrant workers aged 16-57 years were studied. Clustered logistic regression analyses revealed that women who never or seldom experienced lubrication difficulties had a lower risk of recent two-week morbidity (adjusted odds ratio [OR] = 0.32, 95% confidence interval [CI] = 0.17-0.60, P less then 0.001; adjusted OR = 0.35, 95% CI = 0.18-0.69, P= 0.003) than those who always experienced lubrication difficulties; women who never felt a lack of sexual interest had a significantly lower risk of annual hospitalization (adjusted OR = 0.40, 95% CI = 0.20-0.79, P= 0.009) than those who always or seldom lacked sexual interest, and women who never felt sexual satisfaction had a higher risk of annual hospitalization (adjusted OR = 3.08, 95% CI = 1.75-5.42, P less then 0.001) than those who always or seldom experienced sexual satisfaction. The independent contributions of sexuality-related factors to the risk of recent two-week morbidity and annual hospitalization were 5.