Mccartystrauss5741

To develop and test an internationally applicable mapping function for converting WHODAS-2.0 scores to disability weights, thereby enabling WHODAS-2.0 to be used in cost-utility analyses and sectoral decision-making.

Data from 14 countries were used from the WHO Multi-Country Survey Study on Health and Responsiveness, administered among nationally representative samples of respondents aged 18+ years who were non-institutionalized and living in private households. For the combined total of 92,006 respondents, available WHODAS-2.0 items (for both 36-item and 12-item versions) were mapped onto disability weight estimates using a machine learning approach, whereby data were split into separate training and test sets; cross-validation was used to compare the performance of different regression and penalized regression models. Sensitivity analyses considered different imputation strategies and compared overall model performance with that of country-specific models.

Mapping functions converted WHODAS-2.0 scores into disability weights; R-squared values of 0.700-0.754 were obtained for the test data set. Penalized regression models reached comparable performance to standard regression models but with fewer predictors. Imputation had little impact on model performance. Model performance of the generic model on country-specific test sets was comparable to model performance of country-specific models.

Disability weights can be generated with good accuracy using WHODAS 2.0 scores, including in national settings where health state valuations are not directly available, which signifies the utility of WHODAS as an outcome measure in evaluative studies that express intervention benefits in terms of QALYs gained.

Disability weights can be generated with good accuracy using WHODAS 2.0 scores, including in national settings where health state valuations are not directly available, which signifies the utility of WHODAS as an outcome measure in evaluative studies that express intervention benefits in terms of QALYs gained.The de Winter electrocardiograph (ECG) pattern in patients with chest pain is associated with occlusion of the proximal left anterior descending (LAD) artery. These patterns were once considered stable conditions, without dynamic evolution of ECG. Recently, several case reports have indicated that this ECG pattern may evolve into ST-elevation myocardial infarction (STEMI) or may follow the ECG manifestations of STEMI. However, our case report reveals a dynamic evolution from the de Winter pattern to STEMI and then to a normal ECG pattern.

The clinical course and therapeutic strategies in the congenital long QT syndrome (LQTS) are genotype-specific. However, accurate estimation of LQTS genotype is often difficult from the standard 12-lead ECG.

This study aims to evaluate the utility of QT/RR slope analysis by the 24-hour Holter monitoring for differential diagnosis of LQTS genotype between LQT1 and LQT2.

This cross-sectional study enrolled 54 genetically identified LQTS patients (29 LQT1 and 25 LQT2) recruited from three medical institutions. The QT-apex (QTa) interval and the QT-end (QTe) interval at each 15-second were plotted against the RR intervals, and the linear regression (QTa/RR and QTe/RR slopes, respectively) was calculated from the entire 24-hour and separately during the day or night-time periods of the Holter recordings.

The QTe/RR and QTa/RR slopes at the entire 24-hour were significantly steeper in LQT2 compared to those in LQT1 patients (0.262±0.063 vs. 0.204±0.055, p=.0007; 0.233±0.052 vs. 0.181±0.040, p=.0002, respectively). The QTe interval was significantly longer, and QTe/RR and QTa/RR slopes at daytime were significantly steeper in LQT2 than in LQT1 patients. The receiver operating curve analysis revealed that the QTa/RR slope of 0.211 at the entire 24-hour Holter was the best cutoff value for differential diagnosis between LQT1 and LQT2 (sensitivity 80.0%, specificity 75.0%, and area under curve 0.804 [95%CI=0.68-0.93]).

The continuous 24-hour QT/RR analysis using the Holter monitoring may be useful to predict the genotype of congenital LQTS, particularly for LQT1 and LQT2.

The continuous 24-hour QT/RR analysis using the Holter monitoring may be useful to predict the genotype of congenital LQTS, particularly for LQT1 and LQT2.This study investigates under what conditions older spouses receive personal care from their spouse. Whether spousal care is provided is determined by individual and societal factors related to informal and formal care provision. Individual factors concern the need for care (the care recipient's health status), the spouse's ability to provide care (the spouse's health status) and the quality of the marital bond. Societal factors reflect changing policies on long-term care (indicated by the year in which care started) and gender role socialisation (gender). From the Longitudinal Aging Study Amsterdam, which completed eight observations between 1996 and 2016, we selected 221 independently living married respondents, aged 59-93, who received personal care for the first time and had at least one previous measurement without care use. The results show that if an older adult received personal care, the likelihood of receiving that care from the spouse decreased over the years from 80% in 1996 to 50% in 2016. A husband or wife was less likely to receive spousal care when the spouse was unable to provide care or the quality of the relationship was low. No gender differences were found in either the prevalence of spousal care use or in the factors associated with that use. Thus, individual factors and the societal context seem to determine whether one receives personal care from their spouse. The decline in the likelihood of personal care provision from a spouse over the years may indicate a crumbling of family solidarity, an unmeasured and growing inability of the older spouse to provide care or an increasing complexity of care needs that requires the use of formal care. As care-giving can be a chronic stressor and most spouses provide care without assistance from others, attention from policy makers is needed to sustain the well-being of older couples.While demand for care-giving is increasing rapidly among older adults in Korea, there are large unmet care needs. In the face of an elder care crisis, older adults feel uncertain about how and by whom they will be cared for. This study examines the relationship between expectations of receiving care in the future and all-cause mortality among Korean older adults. We explore whether mortality risk differs by sources of care (non-family vs. family caregivers), and further disaggregate different sources of care by family member type (spouse, sons and daughters). Using data from the Korean Longitudinal Study of Ageing (N = 3,111 participants aged 65 or older), we estimate Cox proportional hazards regression models predicting all-cause mortality. Expecting to receive care from either non-family or family members is significantly associated with lower mortality risk. Expecting care from a spouse and/or daughter was associated with lower mortality risk, but expecting care from sons was not. After adjusting for covariates, expecting future care from a spouse and/or daughter predicted lower mortality risk (HR = 0.83; 95% CI = 0.71-0.97 [spouse], HR = 0.79; 95% CI = 0.67-0.94 [daughter]), and the coefficient for expectations of formal care from non-family members became statistically insignificant. After controlling for family structure, only the association between expecting care from daughters and mortality remained statistically significant (HR = 0.78; 95% CI = 0.66-0.94). These effects are more pronounced among women than men. Initiatives to support and maintain high-quality family relationships across the life course and remove barriers that obstruct family members from providing care to their elders would improve older adults' longevity.In the present study, we report the complete genome sequencing of Haloterrigena daqingensis species. 680C91 molecular weight The genome of H. daqingensis JX313T consisted of a circular chromosome with three plasmids. The genome size and G+C content were estimated to be 3835796 bp and 61.7%, respectively. A total of 4158 genes were predicted with six rRNAs and 45 tRNAs. Metabolic pathway analysis suggests that H. daqingensis JX313T codes for all the necessary genes responsible to sustain its life at saline environment. The pan-genome analysis suggests that the number of singleton-gene between H. daqingensis and other Haloterrigena species varied. The study not only helps us understand H. daqingensis strategy for dealing with high stress, but it also provides an overview of its genomic makeup.Metal-organic frameworks (MOFs) have attracted tremendous attention for several novel applications. However, functional MOFs with light-responsive circularly polarized luminescence (CPL) are not examined in detail. Therefore, a dual CPL switch exhibiting both upconversion (UC) and downshifting (DS) CPL in the solid state is constructed by loading a luminescent diarylethene derivative (DAEC) and UC nanoparticles (UCNPs) into chiral MOFs. The chiral MOF⊃DAEC composites exhibit both photoswitchable luminescence and DS-CPL properties under alternating UV and visible light irradiation. Additionally, a reversible UC-CPL switch is realized using near-infrared (NIR) and visible light irradiation by introducing energy-level-matched UCNPs and DAEC into the chiral MOFs. The dissymmetry factor (glum ) of UC-CPL is noted to be significantly amplified through energy transfer compared to that of DS-CPL, which indicates that the information on circular polarization can be manipulated by altering the incident light. A chiroptical logic circuit with a 2D information output is designed with UV, visible, and NIR light as inputs by setting a rational threshold.

The purpose of this study was to investigate the association between the maternal experience of intimate partner violence (IPV) and children's behavioral problems.

The secondary data of the National Survey on Women's Health and Life Experience, which included 980 Cambodian children aged 6-12years whose mothers responded to questions, were analyzed.

IPV was measured as any experience of physical or sexual violence against a woman by her husband. The children's behavioral problems were indicated by nightmares, bed-wetting, timidity, and aggressive behavior as reported by their mothers.

The children of the women who had experienced sexual violence had a higher prevalence of nightmares (adjusted OR (aOR)=2.22, 95% CI 1.421-3.470), bed-wetting (aOR=2.15, 95% CI 1.398-3.308), and timidity (aOR=1.80, 95% CI 1.075-3.019) than those without reported IPV. The children of mothers who had experienced physical violence had a higher rate of aggression (OR=2.19, 95% CI 1.321-3.630).

The Cambodian children exposed to IPV against their mothers experienced more behavioral problems. This study presents evidence to support changes in current policy to prevent violence and alleviate behavioral problems.

The Cambodian children exposed to IPV against their mothers experienced more behavioral problems. This study presents evidence to support changes in current policy to prevent violence and alleviate behavioral problems.