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Klebsiella pneumoniae is a common species in the gut of mammals and is widely distributed in the environment. However, the environmental source of hvKp that precedes gut colonization is unclear, but once that it reaches the gut there is a possible generalized spread y fecal-oral transmission especially in endemic areas. Liver abscess might develop when the bacteria, using its virulence factors, cross the intestinal barrier and invade the liver by the portal circulation. This syndrome, prevalent mostly in Asian countries, is increasingly reported in Western Countries and leaves open questions about the source of infection.

Here we describe for the first time in Italy, a case of pyogenic liver abscess caused by a hypervirulent Klebsiella pneumoniae (HvKp) complicated by endophthalmitis and other metastatic infections in lung and prostate in an immunocompetent Chinese healthy individual with no recent travel in Asia.

This case underlines the need for increased awareness of hypervirulent K. pneumoniae, even in settings where it occurs infrequently and where there are not evident epidemiological links.

This case underlines the need for increased awareness of hypervirulent K. pneumoniae, even in settings where it occurs infrequently and where there are not evident epidemiological links.

In people with sickle cell disease, sickled red blood cells cause the occlusion of small blood vessels, which presents as episodes of severe pain known as pain crises or vaso-occlusive crises. The pain can occur in the bones, chest, or other parts of the body, and may last several hours to days. Pain relief during crises includes both pharmacologic and non-pharmacologic treatments. The efficacy of inhaled nitric oxide in pain crises has been a subject of controversy; hypotheses have been made suggesting a beneficial response due to its vasodilator properties, yet no conclusive evidence has been presented. This review aimed to evaluate the available randomised controlled studies addressing this topic.

To capture the body of evidence evaluating the efficacy and safety of the use of inhaled nitric oxide in treating pain crises in people with sickle cell disease, and to assess the relevance, robustness, and validity of the treatment to better guide medical practice in the fields of haematology and palliative arms) of using inhaled nitric oxide to treat pain (vaso-occlusive) crises in people with sickle cell disease. Large-scale, long-term trials are needed to provide more robust data in this area. Patient-important outcomes (e.g. measures of pain and time to pain resolution and amounts of analgesics used), as well as use of healthcare services, should be measured and reported in a standardised manner.

The currently available evidence is insufficient to determine the effects (benefits or harms) of using inhaled nitric oxide to treat pain (vaso-occlusive) crises in people with sickle cell disease. Large-scale, long-term trials are needed to provide more robust data in this area. Patient-important outcomes (e.g. measures of pain and time to pain resolution and amounts of analgesics used), as well as use of healthcare services, should be measured and reported in a standardised manner.

In this study, it was aimed to evaluate the relationship of hedonic hunger with food addiction and obesity in university students.

The research sample consists of 275 university students between the ages of 19-28years. Body weight (kg), height (cm), waist and hip circumference (cm) were measured by applying a face-to-face questionnaire including descriptive characteristics of individuals, the Power of Food Scale (PFS), the Palatable Eating Motive Scale (PEMS) and the Modified Yale Food Addiction Scale (mYFAS) 2.0. Statistical analysis of the data was done with SPSS (Statistical Package for Social Sciences) 18.

In individuals, according to the mean PFS score the presence of food power-induced hedonic hunger was detected. While according to the mean PEMS score no motivational hedonic hunger was detected. According to the BMI classification the average scores of PFS (p = 0.002), PEMS (p = 0.009), and mYFAS 2.0 (p < 0.001) showed a gradual increase from underweight to obese. A weak positive correlation was found between BMI and PFS score (r = 0.238; p < 0.05) and PEMS score (r = 0.196; p < 0.05), respectively. The moderate positive correlation (r = 0.439 p < 0.001) was found between mYFAS 2.0 and the PEMS scores.

As a result, the presence of food-based hedonic hunger was determined in young individuals. https://www.selleckchem.com/products/Dihydromyricetin-Ampeloptin.html A relationship was determined between food addiction and hedonic hunger caused by the motivation to consume delicious foods. Accordingly, hedonic hunger is related to food addiction and obesity in university students.

V, cross-sectional descriptive study.

V, cross-sectional descriptive study.Lactic and formic acid are two commonly found monocarboxylic organic acids. Lactic acid is discharged into the water bodies as acidic industrial effluent from the food, cosmetic, chemical, and pharmaceutical industries, whereas formic acid is discharged from various paper, leather tanning, and textile processing industries. The present study investigated the toxicity of both organic acids upon the benthic oligochaete worm Tubifex tubifex. The 96-h median lethal concentration (LC50) values for lactic and formic acid are determined as 143.81 mg/l and 57.99 mg/l respectively. The effects of two sublethal concentrations (10% and 30% of 96 h LC50) of these acids on differential expression of oxidative stress enzymes are investigated. The comparative analysis of acute toxicity demonstrates that formic acid exposure is more detrimental to T. tubifex than lactic acid. The in silico structural analysis predicts that formic acid can interact with cytochrome c oxidase of the electron transport system and thereby inhibits its functionality and induces reactive oxygen species production. Integrated biomarker response (IBR) analysis illustrates that overall oxidative stress of formic acid to T. tubifex is significantly higher than that of lactic acid, which supports the structural analysis. It is concluded from this study that toxicokinetic-toxicodynamic and species sensitivity distributions studies are helpful for ecological risk management of environmental toxicants.Topiramate has multiple pharmacological mechanisms that are efficient in treating epilepsy and migraine. Ginger has been established to have gingerols and shogaols that cause migraine relief. Moreover, Topiramate has many off-label uses. Thus, it was necessary to explore the possible neurotoxicity of Topiramate and the role of ginger oil in attenuating the Topiramate neurotoxicity. Male albino mice were orally gavaged with Topiramate, ginger oil (400 mg/kg), and Topiramate plus ginger oil with the same pattern for 28 days. Oxidative stress markers, acetylcholinesterase (AchE), gamma-aminobutyric acid (GABA), and tumor necrosis factor-alpha (TNF-α) were examined. Histopathological examination, immunohistochemical glial fibrillary acidic protein (GFAP), and Bax expression analysis were detected. The GABAAR subunits, Gabra1, Gabra3, and Gabra5 expression, were assessed by RT-qPCR. The investigation showed that Topiramate raised oxidative stress markers levels, neurotransmitters, TNF-α, and diminished glutathione (GSH). In addition, Topiramate exhibited various neuropathological alterations, strong Bax, and GFAP immune-reactivity in the cerebral cortex. At the same time, the results indicated that ginger oil had no neurotoxicity. The effect of Topiramate plus ginger oil alleviated the changes induced by Topiramate in the tested parameters. Both Topiramate and ginger oil upregulated the mRNA expression of gabra1 and gabra3, while their interaction markedly downregulated them. Therefore, it could be concluded that the Topiramate overdose could cause neurotoxicity, but the interaction with ginger oil may reduce Topiramate-induced neurotoxicity and should be taken in parallel.Schemes to protect the geological environment and reclaim land are core requirements for an application for mining rights and complying with mining regulations. Mining enterprises must be supervised to ensure they fulfill their obligations. To guide oversight of such schemes and to provide references for their compilation and review, this study evaluates land reclamation schemes in mining areas using a multi-attribute group decision-making method. First, linguistic intuitionistic fuzzy numbers are used to describe the evaluation information. Considering the authority and preferences of experts, methods for determining expert weights in four cases are established. Max-min deviation then determines the attribute weights, and a method for linguistic intuitionistic fuzzy group decision-making is proposed. Finally, the practicability of this method is verified through a comparative analysis of land reclamation schemes for four mining areas in Sichuan Province, China. The results show the proposed method to give simple and effective evaluation, making it reasonably applicable to the compilation and review of land reclamation schemes.Harmful cyanobacterial blooms are increasing in frequency and severity, which makes their toxic secondary metabolites of microcystins (MCs) have been widely studied, especially in their distribution and influence factors in different habitats. However, the distribution of MCs on the early growth stage of harmful cyanobacteria and its influence factors and risks are still largely unknown. Thus, in the present study, two reservoirs (Lutian Reservoir and Lake Haitang) with different trophic status in China have been studied weekly from March to May in 2018, when the cyanobacteria communities were just in the early growth stage, to investigate the variation of MCs concentration and the relationships between MCs and environmental parameters. During the investigation, Lutian Reservoir and Lake Haitang were found to be mesotrophic and light eutrophic, respectively. In Lutian Reservoir, the concentration of EMCs (extracellular MCs) was obviously higher than that of IMCs (intracellular MCs) with a mean value of 0.323 on, the coexistence of the dominant species of Pseudoanabaena sp., which can produce a taste-and-odor compound of 2-methylisoborneol (2-MIB), might have a significant impact on the concentration and toxicity of MCs. Our results suggested that the risks posed by MCs at the early growth stage of cyanobacteria should also deserve our attention, especially in mesotrophic water bodies.Strategic valorization of readily available sugarcane bagasse (SB) is very important for waste management and sustainable biorefinery. Conventional SB pretreatment methods are ineffective to meet the requirement for industrial adaptation. Several past studies have highlighted different pretreatment procedures which are lacking environmentally benign characteristics and effective SB bioconversion. This article provides an in-depth review of a variety of environmentally acceptable thermochemical and biological pretreatment techniques for SB. Advancements in the conversion processes such as pyrolysis, liquefaction, gasification, cogeneration, lignin conversion, and cellulose conversion via fermentation processes are critically reviewed for the formation of an extensive array of industrially relevant products such as biofuels, bioelectricity, bioplastics, bio adsorbents, and organic acids. This article would provide comprehensive insights into several crucial aspects of thermochemical and biological conversion processes, including systematic perceptions and scientific developments for value-added products from SB valorization.