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Simulation has been key to the successful implementation of many of these strategies.

COVID-19 has pushed PEDs to rapidly adapt to evolving clinical and societal needs, with both resultant challenges and positive advances. Further experience and research will guide how in the face of a global pandemic we can further optimize the clinical and operational care of children and youth, ensure robust educational training programs, and maintain provider safety and wellness.

COVID-19 has pushed PEDs to rapidly adapt to evolving clinical and societal needs, with both resultant challenges and positive advances. Further experience and research will guide how in the face of a global pandemic we can further optimize the clinical and operational care of children and youth, ensure robust educational training programs, and maintain provider safety and wellness.

Acute respiratory distress syndrome (ARDS) is a common manifestation of severe COVID-19. Prone positioning has been used successfully in adult patients with ARDS and has been shown to decrease mortality. The efficacy of prone positioning in pediatric ARDS is less clear. In this review, we discuss the physiologic principles and literature on prone positioning in adults and children relative to COVID-19.

There are limited published data on prone positioning in respiratory failure because of COVID-19. The use of proning in nonintubated patients with COVID-19 may improve oxygenation and dyspnea but has not been associated with improved outcomes. Initial adult cohort studies of intubated patients undergoing prone positioning in severe ARDS related to COVID-19 have shown an improvement in mortality. Although the use of proning in children with severe COVID-19 is recommended, data supporting its use is scarce.

Additional studies to evaluate the efficacy of prone positioning in pediatric ARDS are needed to provide evidence for or against this treatment strategy in children. Given the unknown evolution of this pandemic, collaborative research efforts across pediatric centers provides the greatest opportunity to develop a data driven-approach to make use of this potential therapy.

Additional studies to evaluate the efficacy of prone positioning in pediatric ARDS are needed to provide evidence for or against this treatment strategy in children. Given the unknown evolution of this pandemic, collaborative research efforts across pediatric centers provides the greatest opportunity to develop a data driven-approach to make use of this potential therapy.

HIV is perceived as a taboo topic in Iranian culture. This study examined HIV-related stigma among Iranian people living with HIV (PLWH). This cross-sectional study was conducted among 123 PLWH in 2019. HIV-related stigma was assessed by a standardized questionnaire adapted into Persian for this study. Vafidemstat solubility dmso The range of the stigma scores for each of the subscales (personalized stigma, negative self-image, disclosure concerns, and concerns about public attitudes) was 3-12, whereas the range for the total stigma score was 12-48. The highest and lowest mean scores were observed in concerns about public attitudes (10.07) and negative self-image (7.39). The total mean stigma score was 37.03, indicating a high level of stigma. The most important factors determining HIV-related stigma were socioeconomic status, transmission method, duration of disease, and education level. This study suggests the need for more effective interventions to reduce HIV-related stigma among Iranian PLWH.

HIV is perceived as a taboo topic in Iranian culture. This study examined HIV-related stigma among Iranian people living with HIV (PLWH). This cross-sectional study was conducted among 123 PLWH in 2019. HIV-related stigma was assessed by a standardized questionnaire adapted into Persian for this study. The range of the stigma scores for each of the subscales (personalized stigma, negative self-image, disclosure concerns, and concerns about public attitudes) was 3-12, whereas the range for the total stigma score was 12-48. The highest and lowest mean scores were observed in concerns about public attitudes (10.07) and negative self-image (7.39). The total mean stigma score was 37.03, indicating a high level of stigma. The most important factors determining HIV-related stigma were socioeconomic status, transmission method, duration of disease, and education level. This study suggests the need for more effective interventions to reduce HIV-related stigma among Iranian PLWH.

African Americans are disproportionally affected by HIV/AIDS compared with other races/ethnicities, yet few studies have examined the cultural and/or attitudinal precursors that can make African American women vulnerable to HIV-related stigma in the rural South. This study qualitatively explored the meaning and perceptions of HIV-related stigma among African American women in Florida. Thirteen semi-structured interviews were conducted using an empirical phenomenological approach. Five observer perspectives and 26 participant perspectives emerged. Participants described stigma through self-conceptualizations (e.g., ignorance), experiences (e.g., judgments), psychological dysfunction (e.g., mental health), intersectionality (e.g., race, disability), and overcoming stigma (e.g., advocacy). Our findings reveal that HIV-related stigma is unpleasant for African American women. However, over time, women in this study developed strategies to combat stigma. Elements of stigma reduction described in this study may be, women in this study developed strategies to combat stigma. Elements of stigma reduction described in this study may be an important starting point for designing a culturally targeted intervention for African American women living with HIV.The separation of malignant mesothelioma from non-small cell lung carcinomas can be a difficult problem. Sex-determining region Y box 6 (SOX6) and disabled homolog 2 (DAB2) have recently been proposed as sensitive/specific markers of mesothelial lineage, but have not yet been independently tested for utility in mesothelioma diagnosis. Using tissue microarrays containing mesotheliomas (epithelioid n=40, sarcomatoid n=23) and non-small cell lung carcinomas (adenocarcinoma n=52, squamous cell carcinoma n=57, large cell carcinoma n=12) we evaluated the performance of SOX6 and DAB2 by themselves, in conjunction with other established mesothelioma markers (calretinin, WT1, D2-40, CK5/6, HEG1) and combined with 3 broad-spectrum established carcinoma markers claudin-4, MOC31, and BerEP4. For epithelioid mesothelioma, SOX6 and DAB2 had sensitivities of 85% and 98%, respectively. For sarcomatoid mesothelioma, SOX6 had a sensitivity of 13% and DAB2 could not be assessed due to background stromal staining. For SOX6 alone, specificity for mesothelioma versus adenocarcinoma, squamous cell carcinoma, and large cell carcinoma was 94%, 79%, and 92%, respectively, while for DAB2 specificity was 77%, 86%, and 67%.