Lynggaardallen2713

A goal of behavior-analytic interventions is to produce behavior that is maintained under naturalistic conditions. In this experiment, we studied the effects of a speaker immersion protocol (SIP) on the number of speaker responses (tacts and mands) emitted by 3 preschool students under naturalistic, not directly targeted, conditions. During the SIP, the researchers provided 100 daily opportunities for the participants to emit mands using the target mand form by contriving establishing operations (EOs) throughout the school day. The effects of the intervention were evaluated using a multiple-probe design by measuring target mands during EO probe sessions and the number of mands and tacts emitted during noninstructional-setting probe sessions. The researchers found that the SIP produced increases in both targeted and generalized verbal behavior.In the present study, experimenters evaluated the influence of lag schedules of reinforcement in combination with accurate and inaccurate (complete and incomplete) rules on the response variability of naming category items for typically developing preschoolers in a group format. Results showed that when lag schedules were introduced with 2 categories, response variability generalized to the third category. Furthermore, after participants experienced the lag schedule, variability persisted when the contingency no longer required variability. Participants continued to vary their responses unless the rule and contingency required them to repeat responses. We discuss potential clinical applications of using lag schedules in a group format and including rules during teaching, as well as directions for future research in this area.We sought to evaluate the efficacy of successive matching training for establishing generalized reflexive matching across 4 children with autism. In Experiment 1, differential reinforcement with delay fading was efficacious in establishing "yes" and "no" matching and nonmatching responses in 2 participants when 2 identical or nonidentical picture stimuli were presented. In addition, emergent visual-visual reflexive relational responses were observed using novel picture stimuli in a transfer test phase. In Experiment 2, differential reinforcement alone was efficacious in establishing matching and nonmatching responses in the other 2 participants when 2 identical or nonidentical objects were presented. Transfer to identical objects presented through touch (i.e., tactile discrimination) was additionally observed for both participants. Procedures in the study were adapted from the PEAK Relational Training System to aid in clinical replication, and the translational results have implications for language training with individuals with autism.Children who are diagnosed with autism spectrum disorder (ASD) often fail to show equivalence class formation. This may be related to their difficulty in learning the programmed baseline conditional discriminations. The present study investigated equivalence class formation after training visual identity-matching performance with auditory class-specific consequences in 6 individuals who were diagnosed with ASD and who achieved different levels (Levels 4, 5, and 6) on the Assessment of Basic Learning Abilities-Revised (ABLA-R). The potentially emergent relations were all arbitrary (relations between completely dissimilar stimuli) visual-visual (AB and BA) and auditory-visual (SA and SB). None of the participants who achieved ABLA-R Level 4 or 5 responded in accord with equivalence class formation. They did not present any emergent arbitrary conditional relations (either visual-visual relations or auditory-visual relations). Only participants who achieved ABLA-R Level 6 demonstrated equivalence class formation. Selleckchem NVP-CGM097 These findings are consistent with the predictive ability of the ABLA-R with regard to the acquisition of discriminations and to the emergence of the same type of conditional relations and the same hierarchy of complexity.We examined emergent tact control following stimulus pairing, using 2 different stimulus presentation arrangements. In the word-first condition, presentation of the auditory stimulus preceded the visual stimulus, and in the image-first condition, the visual stimulus preceded the auditory stimulus. Eight children (2-5 years old) participated. In Experiment 1, 4 children were exposed to 3 sessions in each condition with a new set of stimuli in each session. In Experiment 2, 2 of the same children received repeated exposure to the same stimulus sets. Experiment 3, with new participants, was identical to Experiment 1, except visual and auditory stimuli overlapped during the presentation. Postsession probes documented emergent stimulus control over 1 or more vocal responses for 7 of the 8 participants. Participants were more likely to make echoic responses with the visual stimulus present in the word-first condition; however, emergent tact control was unaffected by the order of the stimulus presentation. Additional research is needed on stimulus-pairing procedures and on the role of echoic responding in emergent tact control.A common practice in tact training is to include a supplemental verbal stimulus (e.g., "What is it?") in addition to the presentation of a nonverbal discriminative stimulus. Previous literature has suggested that this supplemental verbal stimulus can impede acquisition and generalization relative to the presentation of the object alone, as it may establish faulty stimulus control or decrease spontaneous tacting. Research has yet to compare these 2 training methods on the generalization of learned tacts to more naturalistic, play-based environments. The present study evaluated the use of "What is it?" compared to the presentation of only the nonverbal discriminative stimulus on tact acquisition among 3 children with autism spectrum disorder and the extent to which these training procedures led to tacting in a play-based setting following discrete-trial training. Overall, participants learned to tact stimuli under both conditions, and all participants demonstrated generalization of tacts in a play-based setting. Recommendations for the development and evaluation of naturalistic posttraining assessment are discussed.Lag reinforcement schedules have been shown in previous research to be an effective intervention for teaching verbal and nonverbal response variability to individuals with developmental disabilities. In more recent research, variability itself has been considered a reinforceable behavior in its own right (Susa & Schlinger, The Analysis of Verbal Behavior, 18, 125-130, 2012). Lag x schedules of reinforcement can be used to teach variability by using contingencies that require responses to differ from previous responses. The present study extended Susa and Schlinger's, The Analysis of Verbal Behavior, 18, 125-130, (2012) research by using 3 social questions instead of 1 in a random rotation and included probes to test for generality. A changing-criterion design was used to evaluate the results with one 11-year-old female participant diagnosed with autism. During baseline, the participant provided little variability, with rote responses. During the Lag 1 and Lag 2 phases, appropriate variable verbal responding increased with the use of echoic prompts, visual aids, and an error correction procedure. Further, the results also showed that the participant learned to vary her responses by demonstrating the ability to emit 11 novel prompted responses and 13 spontaneous responses. In addition, the participant was able to retain the skills learned in a maintenance probe conducted 4 weeks postintervention.An electrochemically driven nicotinamide recycling system, referred to as the 'electrochemical leaf' has unique attributes that may suit it to the small-scale industrial synthesis of high-value chemicals. A complete enzyme cascade can be immobilized within the channels of a nanoporous electrode, allowing complex reactions to be energized, controlled and monitored continuously in real time. The electrode is easily prepared by depositing commercially available indium tin oxide (ITO) nanoparticles on a Ti support, resulting in a network of nanopores into which enzymes enter and bind. One of the enzymes is the photosynthetic flavoenzyme, ferredoxin NADP+ reductase (FNR), which catalyzes the quasi-reversible electrochemical recycling of NADP(H) and serves as the transducer. The second enzyme is any NADP(H)-dependent dehydrogenase of choice, and further enzymes can be added to build elaborate cascades that are driven in either oxidation or reduction directions through the rapid recycling of NADP(H) within the pores. In this Article, we describe the measurement of key enzyme/cofactor parameters and an essentially linear scale-up from an analytical scale 4 mL reactor with a 14 cm2 electrode to a 500 mL reactor with a 500 cm2 electrode. We discuss the advantages (energization, continuous monitoring that can be linked to a computer, natural enzyme immobilization, low costs of electrodes and low cofactor requirements) and challenges to be addressed (optimizing minimal use of enzyme applied to the electrode).Background  Sinonasal adenocarcinoma (SNAC) is a rare malignancy arising from mucus-secreting glandular tissue. Limited large-scale studies are available due to its rarity. We evaluated SNAC in the National Cancer Database (NCDB), a source that affords multi-institutional, population studies of rare cancers and their outcomes. Methods  The NCDB was queried for adenocarcinoma in the sinonasal tract. Multivariate analyses were performed to evaluate for factors contributing to overall survival (OS). Results  A total of 553 patients were identified. The cohort was composed of 59.3% males. The nasal cavity was the most common primary site, representing 44.1% of cases. About 5.7% of patients presented with nodal disease, while 3.3% had distant metastases. About 40.6% of cases presented with stage IV disease. About 73.5% of patients underwent surgery, 54.2% received radiation therapy, and 27.7% had chemotherapy. Median OS was 71.7 months, while OS at 1, 2, and 5 years was 82, 73.0, and 52%, respectively. On multivariate analysis, advanced age (hazard ratio [HR] 1.04; 95% confidence interval [CI] 1.02-1.05), Charlson-Deyo score of 1 (HR 1.99; 95% CI 1.20-3.30), advanced tumor grade (HR 2.73; 95% CI 1.39-5.34), and advanced tumor stage (HR 2.71; 95% CI 1.33-5.50) were associated with worse OS, whereas surgery (HR 0.34; 95% CI 0.20-0.60) and radiation therapy (HR 0.55; 95% CI 0.33-0.91), but not chemotherapy (HR 1.16; 95% CI 0.66-2.05), predicted improved OS. Conclusions  SNAC is a rare malignancy with 5-year survival approximating 50%. Surgery and radiation therapy, but not chemotherapy, are associated with improved survival, and likely play a critical role in the interdisciplinary management of SNAC.Objective  To investigate on the feasibility and safety of a new approach which consists of delaying instrumentation after destabilizing craniovertebral junction (CVJ) chordoma surgery, allowing proton beam radiotherapy to be performed in a metal-free tumoral cavity. Design  This is a retrospective series of a prospectively maintained database. Participants  Five consecutive patients operated on for a CVJ chordomas for which instrumentation after tumor resection was deferred to after radiotherapy treatment. Main Outcome Measures  The main outcome consisted of measurements of the following parameters C0-C2 angle, atlanto-dens interval (ADI), condylar gap, and the position of the dens relative to McGregor's line and coronal inclination, performed at 3 different times for all patients before tumor surgery (baseline), before instrumentation surgery, and after instrumentation surgery. Results  For all patients, CVJ parameters deteriorated during the delay period, but stayed within normal limits for most. Because of radiological instability, one patient necessitated instrumentation before receiving radiotherapy.