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Vitamin D deficiency (VDD) is prevalent in polycystic ovary syndrome (PCOS) and the relationship between dyslipidemia and vitamin D status is close. This meta-analysis was to evaluate the effect of vitamin D (alone or with co-supplementation) on lipid profile in PCOS patients.

Medline, the Cochrane Library, PubMed, and Web of Science were searched, and randomized controlled trials (RCTs) published prior to January, 2020 were identified. The pooled estimates of standardized mean deviation (SMD) with 95% confidence intervals (CI) were calculated using a fixed effect model or random effect model.

A total of 954 identified studies were retrieved, and 11 RCTs involving 677 participants were ultimately included in the meta-analysis. The pooled results suggested an association between vitamin D supplementation and a reduction in total cholesterol (TC) concentrations (SMD -0.36 mg/dL, 95% CI -0.54 to -0.18 mg/dL, P<0.0001), triglycerides (TG) (SMD -0.50 mg/dL, 95% CI -0.68 to -0.32 mg/dL, P<0.00001), low-density lipoprotein cholesterol (LDL-C) (SMD -0.28 mg/dL, 95% CI -0.45 to -0.11 mg/dL, P=0.001), and very low-density lipoprotein cholesterol (VLDL-C) (SMD -0.54 mg/dL, 95% CI -0.74 to -0.35 mg/dL, P<0.00001), but no effect on high-density lipoprotein cholesterol (HDL-C) (SMD 0.01 mg/dL, 95% CI -0.16 to 0.18 mg/dL, P=0.89) was found. Subgroup analyses showed that the dosage of vitamin D used, the duration of intervention and the type of vitamin D supplementation (alone or with co-supplementation) might influence the effect of vitamin D on the lipid profile.

This meta-analysis demonstrated that PCOS patients with the therapy of vitamin D had a statistical improvement in TC, TG, LDL-C, and VLDL-C, but did not affect HDL-C concentrations.

This meta-analysis demonstrated that PCOS patients with the therapy of vitamin D had a statistical improvement in TC, TG, LDL-C, and VLDL-C, but did not affect HDL-C concentrations.

Alprostadil can effectively dilate blood vessels, improve cardiac microcirculation, and reduce cardiac load. Tanshinone IIa injection can protect against atherosclerosis and reduce myocardial oxygen consumption. However, the effects of alprostadil combined with tanshinone IIa injection on microcirculation disorder, outcomes, and cardiac function in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) are still not fully clear.

A total of 300 AMI patients who underwent PCI in our hospital from January 2013 to June 2018 were randomly selected and divided into group A, B, C by using the random number table method, with 100 patients in each group. selleck chemicals llc The group A was treated with alprostadil, the group B was treated with tanshinone IIa injection, and the group C was treated with alprostadil combined with tanshinone IIa injection. 7 days after treatment, the cardiac functions of all patients were observed by ultrasonic Doppler, as were the microcirculations by myocardial c as malignant arrhythmia, recurrent heart failure (HF), recurrent myocardial infarction, and death, in the group C were significantly lower than those in the group A and B (PP<0.05).

For AMI patients after PCI, alprostadil combined with tanshinone IIa injection can effectively improve microcirculation and ventricular remodeling, improve cardiac function and reduce the occurrence of MACEs. link2 This combination can be widely used in clinical practice.

For AMI patients after PCI, alprostadil combined with tanshinone IIa injection can effectively improve microcirculation and ventricular remodeling, improve cardiac function and reduce the occurrence of MACEs. This combination can be widely used in clinical practice.

To estimate the prevalence of polycystic ovarian syndrome (PCOS) in Chinese women comprehensively and to provide references to prevent PCOS.

China National Knowledge Infrastructure, Wanfang Data, China Science and Technology Journal Database, Chinese Biology Medicine, PubMed, Embase, Web of Science, CENTRAL, CINAHL were searched to collect studies on the prevalence of PCOS from database inception from March 31, 2020. Two reviewers independently screened literature according to the inclusion and exclusion criteria of the articles, extracted data, and tested the risk of bias of the included studies. Then Stata 15.1 software performed a meta-analysis. Begg's and Egger's method were used to assess the risk of publication bias.

A total of 69 studies were involved, including 154,599 participants, 12,845 patients developed PCOS. The prevalence of PCOS was 10.01% (95% CI 8.31% to 11.89%). Subgroup analysis showed that the prevalence of PCOS in different regions was as follows 13.35% in the west, 7.82% in the ea survey time, and prevalence of the surveyed population.

The prevalence rate of PCOS is high in Chinese women, and the prevalence of PCOS varies with different regions, occupation/identity, age, time of publication, diagnostic criteria, survey time, and prevalence of the surveyed population.

Elderly patients with painless colonoscopy often complain listlessness, fatigue when they left postanesthesia care unit (PACU). These patients also commonly occur hypotension during anesthesia. However, intravenous infusion and blood volume assessment are seldom performed in elderly patients. Therefore, we aimed to observe the effect of intravenous infusion and to explore the value of inferior vena cava diameter (IVCD) measurement by ultrasound in rapid recovery.

Randomized, controlled, clinical trials, elderly patients (aged ≥60 years) with painless colonoscopy were randomly divided into two groups intravenous infusion versus no intravenous infusion was administered procedure. The primary outcome observed was the time required for complete recovery from anesthesia. Secondary outcomes included willingness to accept follow-up colonoscopy, discomfort symptoms, changes in the inferior vena cava (IVC)-related parameters. Hypotension was defined as a ≥20% decrease in systolic blood pressure (SBP) from baselineless colonoscopy. Measurement of the IVCDmax can help to guide intravenous infusion.

Intravenous infusion promotes the rapid recovery of elderly patients with painless colonoscopy. Measurement of the IVCDmax can help to guide intravenous infusion.Mesenchymal stromal cells (MSCs) have been isolated from numerous sources and are potentially therapeutic against various diseases. Umbilical cord-derived MSCs (UC-MSCs) are considered superior to other tissue-derived MSCs since they have a higher proliferation rate and can be procured using less invasive surgical procedures. However, it has been recently reported that 2D culture systems, using conventional cell culture flasks, limit the mass production of MSCs for cell therapy. link3 Therefore, the development of alternative technologies, including microcarrier-based cell culture in bioreactors, is required for the large-scale production and industrialization of MSC therapy. In this study, we aimed to optimize the culture conditions for UC-MSCs by using a good manufacturing practice (GMP)-compatible serum-free medium, developed in-house, and a small-scale (30 mL) bioreactor, which was later scaled up to 500 mL. UC-MSCs cultured in microcarrier-based bioreactors (MC-UC-MSCs) showed characteristics equivalent to those cultured statically in conventional cell culture flasks (ST-UC-MSCs), fulfilling the minimum International Society for Cellular Therapy criteria for MSCs. Additionally, we report, for the first time, the equivalent therapeutic effect of MC-UC-MSCs and ST-UC-MSCs in immunodeficient mice (graft-versus-host disease model). Lastly, we developed a semi-automated cell dispensing system, without bag-to-bag variation in the filled volume or cell concentration. In summary, our results show that the combination of our GMP-compatible serum-free and microcarrier-based culture systems is suitable for the mass production of MSCs at an industrial scale. Further improvements in this microcarrier-based cell culture system can contribute to lowering the cost of therapy and satisfying several unmet medical needs.Oftentimes, to understand the genetic relatedness and diversity of today's populations requires considering the ancient landscape on which those populations evolved. Nowhere is this clearer than along Earth's coastline, which has been in its present-day configuration for only about 6.5% of the past 800,000 years (Dolby et al., 2020; Miller et al., 2005). During ice ages when glaciers expanded in the Northern Hemisphere, they stored enough of the planet's water to drop global sea level by ~120 m below present levels ("lowstand", Figure 1a), and there have been at least eight of these 100,000-year cycles preceding today. When glaciers melted, ocean water reflooded shorelines, shifting and re-forming marginal marine habitats globally and shaping the relatedness of populations (Dolby et al., 2016). In a From the Cover article in this issue of Molecular Ecology, Stiller et al. (2020) integrate population genomic analysis of leafy seadragons in southern Australia with estimates of available seabed area to reveal that the expansion of habitat that accompanied this reflooding led to strong demographic expansions. With statistical models, they also show that western populations were eliminated and then recolonized because the continental shelf there is narrow, leaving little available habitat when sea level was low (Figure 1b). Their results document the dynamic and interrelated nature of a hidden, changing landscape and the evolution of species inhabiting it.

To understand factors associated with repeat non-attendance at screening for diabetes-related retinopathy.

Retrospective observational study using anonymised data from Diabetic Eye Screening Wales for people with a full history of screening invitations and attendances was linked with primary and secondary care records held in the Secure Anonymised Information Linkage Databank. Repeat non-attendance was defined as no record of attendance during any 36-month period despite three cycles of annual screening invitations. The associations between repeat non-attendance and potential risk factors were examined using multivariable logistic regression analysis, stratified according to type 1 and type 2 diabetes.

A total of 18% with type 1 diabetes (1146/6513) and 8% with type 2 diabetes (12,475/156,525) were repeat non-attenders. Participants attending their very first appointment were least likely to become repeat non-attenders [odds ratio (95% confidence interval)] type 1 diabetes 0.12 (0.09, 0.17) and type 2 diabetes 0.08 (0.07, 0.09). For both types of diabetes, those of a younger age, living in areas of higher deprivation and subject to multiple house moves were at greater risk of becoming repeat non-attenders.

A more tailored approach is needed for the younger population, those living in areas of higher deprivation and/or undergoing multiple residential relocation and to ensure attendance at their initial appointment to minimise future repeat non-attendance.

A more tailored approach is needed for the younger population, those living in areas of higher deprivation and/or undergoing multiple residential relocation and to ensure attendance at their initial appointment to minimise future repeat non-attendance.