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A linguistic resource with annotated medical entities on texts produced in Chilean hospitals was built and made available, working with annotators related to medicine. The iterative annotation approach allowed us to improve performance metrics. The corpus and annotation protocols will be released to the research community.

A linguistic resource with annotated medical entities on texts produced in Chilean hospitals was built and made available, working with annotators related to medicine. The iterative annotation approach allowed us to improve performance metrics. The corpus and annotation protocols will be released to the research community.

Suicide is a public health problem in the world. In Chile, suicide rates increased since 1990 with regional differences in rates.

To analyze the geographical distribution of deaths due to suicide that occurred in the Region of Araucanía between the years 2004-2015.

The geographic distribution of suicide in the Araucania Region at district level (2004-2015) was analyzed using death data available at the web page of the Ministry of Health. Socio-demographic variables of suicide were characterized. The spatial distribution of suicide rates was represented using cartography, and suicide spatial clusters were identified through spatial-temporal exploration.

There were 1,562 suicides, 86% in men, with a mean rate of 13.07 x105 inhabitants. The highest rates were registered in people aged over 70 years. Most individuals committing suicide were active workers. Hanging was the most common method to accomplish suicide. The territories from the coastal area in Cautín, and Nahuelbuta registered the highest suicide rates. Two statistically significant conglomerates with high incidence of suicide cases were identified.

The use of geographic methods and the disaggregation of suicide cases at district level, allowed the identification of territorial variability in the distribution of suicide rates within the Araucanía Region. Spatial patterns of areas with high suicide risk were found.

The use of geographic methods and the disaggregation of suicide cases at district level, allowed the identification of territorial variability in the distribution of suicide rates within the Araucanía Region. Spatial patterns of areas with high suicide risk were found.

Clinical ethics consultation services and their methods vary and they are seldom evaluated. Only one formal system of individual clinical ethics consultation has been reported in Chile, with a ten-year registry.

To evaluate the opinion of intensivist physicians about the contribution of clinical ethics consultation.

An anonymous and voluntary questionnaire consulting their opinion about clinical ethics consultations was sent to 38 intensivist physicians.

The questionnaire was answered by 28 professionals. Eighty four percent of respondents considered that ethics consultation contributed to improve patients' quality of care, 92% responded that this practice helps in decisions about limitation of treatments or life support, and 96% expressed that it also was a positive support for patients and their relatives. Seventy two percent of respondents considered that ethics consultations enhanced their ethical sensibility, 76% that they improved their understanding of clinical ethics topics, and 72% declared that it decreased their stress in complex decision-making.

Clinical ethics consultation provides a positive support for improvements in clinical decision-making and in the quality of patients' care.

Clinical ethics consultation provides a positive support for improvements in clinical decision-making and in the quality of patients' care.

The flipped classroom is an active method where information in delivered before class and the time allocated for it is dedicated to achieving more complex learning objectives. Diverse resources are used in each phase of the methodology. However, Web 2.0 or "Social Web" tools allow greater personal and remote interaction.

To describe the perception about flipped classroom methodology implemented using web 2.0 tools in 48 medical students from the University Mayor.

The students were invited to view four video-classes available on Edpuzzl. During the activity, questions about the topic were inserted to promote understanding, research, and teamwork, then the topic was discussed using Case-Based Learning through the Quizizz program. A survey composed of 12 closed items and an open question was applied to analyze the perceptions of students. Data were analyzed using the SPSS and Atlas-Ti programs.

A high satisfaction rate was observed about the way in which the content, discussion and communication of the information was presented. The methodology encouraged the development of generic competences, but it was not always positively perceived.

The flipped classroom methodology developed with Edpuzzle was very well evaluated by students. This teaching method may be particularly useful in the epidemiological context of COVID-19 and other situations which require distant learning.

The flipped classroom methodology developed with Edpuzzle was very well evaluated by students. This teaching method may be particularly useful in the epidemiological context of COVID-19 and other situations which require distant learning.

The coronavirus 2 pandemic (COVID-19) has caused intense changes in lifestyles, feeding, and nutrition habits.

To analyze food insecurity and eating habits during the period of quarantine in a group of Chilean individuals.

An online survey was conducted in 2,767 households with questions about the sociodemographic composition of the household, household food purchasing habits in the quarantine period for COVID-19, and perception of food insecurity.

More than 60% of households (p < 0.01) were worried about not having enough food, especially when children under 18 years of age lived in them. This perception increased in urban households (p < 0.01) and those located in the Central-Southern and Southern regions (p < 0.01). During the pandemic, the consumption of healthy products such as milk increased in 50% of households, legumes in 72%, eggs in 79%, fruits in 54%, vegetables in 67% and water in 81%. There was also a lower consumption of unhealthy and ultra-processed foods such as hot-dogs in 90% of households, sausages in 73%, sugary drinks in 79% and ice cream in 83%.

The COVID-19 pandemic in Chile increased the perception of food insecurity in households with vulnerable conditions. However, the consumption of healthier foods increased.

The COVID-19 pandemic in Chile increased the perception of food insecurity in households with vulnerable conditions. However, the consumption of healthier foods increased.

Timely eye fundus examinations are essential to prevent the consequences of retinopathy among patients with type 2 diabetes mellitus.

To assess the coverage rate (CR) of eye fundus examination in the Chilean diabetic population, between 2011 and 2019.

Analysis of monthly statistical summaries of the Cardiovascular Health Program published online by the Chilean Ministry of Health. The number of patients aged 15 years or more with a diagnosis of Type 2 diabetes mellitus and the number of those who had an eye fundus examination within the same year, were obtained. Data was analyzed at a national and regional level.

The national eye fundus examination CR was 19.1% in 2011. In 2016, the figures became significantly higher, reaching 32.5%. In 2019, the highest value of 36.5% was recoded although not significantly different from 2016. The highest average annual CR was observed in Ñuble Health Service (49.5%), and the lowest in Central Metropolitan Service (15%). The highest CR positive absolute and relative variation between 2011 and 2019 was observed in Viña del Mar Quillota Health Service (38.9 and 489% respectively), and the lowest negative variation was observed in Araucania Norte Health Service (-8.42 and -24.21% respectively).

There is a low eye fundus examination CR in Chile, with important differences between regional health services.

There is a low eye fundus examination CR in Chile, with important differences between regional health services.

The worldwide incidence of acute pancreatitis (AP) is increasing.

To determine the national incidence of AP between 2013 and 2018.

Analysis of hospital discharge records available at the web page of the Statistical and Information Service of the Chilean Ministry of Health. We recorded the number of patients discharged with a diagnosis of AP, excluding chronic pancreatitis and pancreatic cancer, between 2013 and 2018. We also recorded length of hospital stay, age, etiology, and lethality. Rates of raw and age-adjusted incidence were calculated.

During the study period, 46,420 patients with AP were discharged, with an incidence rate ranging between 39 and 43.7/100,000 inhabitants, and a non-significant increase along time of 8.6%. There are important differences between the average adjusted rates of Northern (Arica to Metropolitan) and Southern regions (O'Higgins to Magallanes), with rates of 36.9 and 53.6/100,000 inhabitants respectively (p < 0.01). The average hospital stay was 11 days. Two thirds of cases were aged between 20 and 64 years. The case fatality was 4.2%, with no decrease between 2013 and 2018. The mortality rate was 1.6/100,000 inhabitants.

The annual incidence of AP is 42.6/100,000 inhabitants, with geographical differences from North to South, which can be associated with the high frequency of biliary tract disease in aboriginal ethnic groups. The age distribution and length hospital stay were stable over time.

The annual incidence of AP is 42.6/100,000 inhabitants, with geographical differences from North to South, which can be associated with the high frequency of biliary tract disease in aboriginal ethnic groups. The age distribution and length hospital stay were stable over time.Parkinson's disease (PD) is a neurodegenerative disorder characterized by nigrostriatal degeneration and the spreading of aggregated forms of the presynaptic protein α-synuclein (aSyn) throughout the brain. PD patients are currently only treated with symptomatic therapies, and strategies to slow or stop the progressive neurodegeneration underlying the disease's motor and cognitive symptoms are greatly needed. selleck chemicals The time between the first neurobiochemical alterations and the initial presentation of symptoms is thought to span several years, and early neuroprotective dietary interventions could delay the disease onset or slow PD progression. In this study, we characterized the neuroprotective effects of isoflavones, a class of dietary polyphenols found in soy products and in the medicinal plant red clover (Trifolium pratense). We found that isoflavone-rich extracts and individual isoflavones rescued the loss of dopaminergic neurons and the shortening of neurites in primary mesencephalic cultures exposed to two PD-related insults, the environmental toxin rotenone and an adenovirus encoding the A53T aSyn mutant. The extracts and individual isoflavones also activated the Nrf2-mediated antioxidant response in astrocytes via a mechanism involving inhibition of the ubiquitin-proteasome system, and they alleviated deficits in mitochondrial respiration. Furthermore, an isoflavone-enriched soy extract reduced motor dysfunction exhibited by rats lesioned with the PD-related neurotoxin 6-OHDA. These findings suggest that plant-derived isoflavones could serve as dietary supplements to delay PD onset in at-risk individuals and mitigate neurodegeneration in the brains of patients.

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