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Objective To investigate the clinicopathological characteristics and molecular genetics of atypical renal cysts. Methods Six cases of atypical renal cysts were collected from Zhejiang Provincial People's Hospital, Hangzhou, China, between February 2014 and February 2019. The clinicopathological characteristics and disease progression were analyzed. The 3p deletion and trisomy of chromosomes 7 and 17 were detected using fluorescence in situ hybridization (FISH). Results All of the 6 patients were male, aged 43-63 years (median 52 years). Preoperative Bosniak classification showed 4 cases of grade Ⅱ, 1 case of grade Ⅰ and 1 of grade Ⅲ. Histologically, atypical renal cysts appeared as unilocular or multilocular cysts, lined by multilayered flattened or cuboidal-shaped clear or eosinophilic cells. They often showed short papillary projections, and lacked solid or nodular growth of the lesional cells within the wall or septa of the cysts. Histologically, these cysts could be classified into three categories acquir of currently known renal cell carcinomas. Extensively sampling and careful observation of the histological characteristics of the cyst wall are important for distinguishing atypical renal cysts from extensively cystic renal cell carcinomas.Objective To investigate the clinicopathological characteristics of eosionphilic Chromophobe renal cell carcinoma (eChRCC), and differences in morphology, immunophenotype and clinical prognosis betweeneChRCC, renal oncocytoma(RO) and classic Chromophobe renal cell carcinoma (cChRCC). Methods The clinicopathologic data of 17 patients diagnosed as eChRCC from the Affiliated Hospital of Qingdao University (13 cases) and 971 Hospital of PLA Navy (4 cases) from October 2006 to February 2019 were collected. Immunohistochemical analysis was carried out to compare the immunophenotypes between 17 cases with ChRCC, 27 cases with RO and 30 cases with cChRCC. Resuls Among the 17 patients, seven were males and ten were females, and the age ranged from 40 to 75 years (median 54 years). Clinically, 15 cases of 17 were found accidentally by physical examination. The tumor size ranged from 1.8 cm to 10.0 cm (average 5.7 cm) and the cut surface of 15 cases were solid, one case was solicl and cystic, and one was cystic. Most shtive expression of cyclin D1, S100A1 are helpful to the diagnosis and differential diagnosis of eChRCC. The prognosis of eChRCC after complete surgical resection is excellent and few cases may have long-term metastasis. There is no significant difference in prognosis between eChRCC and cChRCC, but eChRCC shows better outcome than RO.Ancient medical books have the names of drugs such as "xinghe" (, apricot pit), but there is only the name "xingren" (, almond) in modern medical books. On the basis of checking Chinese dictionary, exegetical books and ancient literature, it is believed that the ancients could clearly distinguish the difference between "he" (, pit) and "ren" (, nut) in actual use, and realized that the pit and the nut are different parts. This article takes almonds as the center to explore the similarities and differences of concepts and essences between the "he" (, pit) and "ren" (, nut) in ancient prescriptions. By investigating the usage of ancient medical literature, it can be seen that the actual medicinal part of the medicine "xinghe" (, apricot pit) means still almonds. Tofacitinib And due to the imperfect market of ancient medicinal materials, there is no perfect medicinal materials processing industry, and it is necessary for doctors to remove part of the non-medicinal parts after obtaining the medicinal materials. Therefore, in ancient times, the "xinghe" (, apricot pit) and "xingren" (, almond) are actually different names for the same medicinal part.Yi Zang Shu Mu(, The List of Medicine Books), written by Yin Zhongchun, is China's earliest medical bibliographer. The years of birth and death of Yin Zhongchun was unknown. By text research, it is confirmed that Yin Zhongchun was born in the 20th Year of Jiajing in Ming Dynasty (1541) and died in the First Year of Tianqi(1621). The only currently existing block-printed edition of Yi Zang Shu Mu is the Fan Xingzhun Qi Fen Shi edition in the library of China Academy of Chinese Medical Sciences. The copies in Japan lack the words " Proofread by Yun Jian Chen Jiru Meigong" , but have an extra preface written by Chen Yidian. This fact indicates that the original of the Japanese copy might be different from the Chinese edition.Yi Lüe Zheng Wu Gai Lun(, Introduction of Corrections to Summaries on Medicine) was written around 1545, the 24th year during Emperor Jiajing's reign in the Ming Dynasty, now it has the only copy extant. Some errors and mistakes happened about this book name and its author in some history books and bibliographies some reference books describe Yi Lüe Zheng Wu Gai Lun and Yi Lüe Zheng Wu (, Corrections to Summaries on Medicine) as two different books, with their own writer Li Xiang and Li Hanyi respectively. In fact, there is only one book, Yi Lüe Zheng Wu Gai Lun and Yi Lüe Zheng Wu is same book. The author is Li Xiang, but Hanyi is his courtesy name that misunderstood as a different person.Some features in the medical prescriptions of western Han dynasty on the wooden slips unearthed in Hujia Pasture were interpreted, and the words were annotated and translated. The study found that this recipe with male magpie excrement treatment epileptic disease is the first moxibustion combined with drugs to treat epilepsy. This is the earliest recorded treatment. The drug is still administered to lactate children by applying it to the mother's nipple and making the child to suck, and it is the earliest recorded of its kind.Rugao and Haian belonging to First Branch of Su-Wan Liberated Area found fulminant cholera in 1946. The fulminant cholera spread throughout the Su-Wan Liberated Area in a short period of time. Thus, local mass and military led by CPC actively launched the Movement of Epidemic Prevention. They took some actions to clear up the circumstance, eliminate the pathogen, prevent the food contamination and cut off the route of transmission. Vaccination was carried out on a large scale. As a result of these measure, the fulminant cholera was efficiently controlled.

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