Strongdean8356

Drug-free PHB-MNPs were not cytotoxic to the SKBR-3, and MCF-7 cells whereas the Gemcitabine loaded PHB-MNPs was about two-fold more cytotoxic with respect to free Gemcitabine. In vitro targeting ability of PHB-MNPs was shown under magnetic field. CONCLUSION Considering these facts, we may suggested that these nanoparticles can be a promising candidate for the development of a novel targeted drug delivery system for breast cancer. Other The targeting ability of PHB-MNPs under magnetic field was shown in in vitro conditions. Furthermore, it was shown that Gemcitabine loaded PHB-MNPs had two folds more cytotoxic effect on both SKBR and MCF-7 breast cancer cell lines with respect to free Gemcitabine. These results suggest that these Gem-PHB-MNPs can have the potential to be a promising candidate for the development of novel targeted drug delivery system for breast cancer. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.INTRODUCTION Hemorrhoidal disease is the most common proctologic condition in adults. Among the different surgical procedures, one of the greatest innovations is represented by the stapled hemorrhoidopexy. The history of this technique started with a single stapler use passing thorough a double stapler technique to resect the adequate amount of prolapse, finally arriving to the use of high volume devices. METHODS Nevertheless each device has its own specific feature, the stapler is basically made up with one or more circular lines of titanium staples whose height may be variable. The procedure is based on different steps Introduction of the CAD, evaluation of the prolapse, fashioning purse string or parachute suture, introduction of the stapler head beyond the suture, pull the wires through the window, close the stapler and keep pulled the wires of the suture held together with a forcep, fire using two hands, open the stapler and remove it and check the staple line and then check the specimen. One of the lateusception as a determining factor involved in the natural history of the disease. Stapled hemorrhoidopexy marked an era in which the surgeon may to offer to the patients a safe, effective treatment with less pain and fast recovery. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND The adoption of guideline recommendations of pharmacotherapy to improve the clinical course of Heart Failure(HF) remains below par. Our objective is to evaluate the impact of clinical audit on adherence to the Guideline-Directed Medical Therapy (GDMT)in patients admitted with acute heart failure with reduced ejection fraction (EF). METHOD A prospective interventional study was conducted over a period of 12 months from June 2018 to May 2019 in all patients admitted with acute heart failure with reduced ejection fraction. The discharge prescriptions of patients who met the inclusion criteria were audited for appropriateness in the usage of neurohormonal blockers and Ivabradine, by a clinical pharmacist on a monthly basis. Audit results were presented to the practicing physicians every month and feedback was given. RESULTS Discharge prescriptions of 716 patients who presented with HF were audited for the reasonable or unreasonable omission of neurohormonal blocking drugs. The first-month audit revealed that the unreasonable omission of Angiotensin Converting Enzyme Inhibitors/ Angiotensin Receptor Blockers/ Angiotensin Receptor Neprilisin Inhibitors ( ACEI/ARB/ARNI), Betablockers and Mineralocorticoid Receptor Antagonists (MRA) were 24.5%, 13.1%, and 9.09% respectively, which reduced to nil at the end of the study period (p=0.00). Initiation of Ivabradine before prescribing or achieving the target dose of Betablocker was noted in 38.18% of patients in the first month which was also reduced to nil (p=0.00) at the end of the study. CONCLUSION This study reveals that periodic clinical audit improves adherence to GDMT in patients admitted with heart failure with reduced ejection fraction. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND The cesarean section has shown an increase in the trends within the past few years. The use of appropriate and effective anesthesia for the procedure is important, not only to reduce the incidence of maternal and fetal morbidities but also to reduce the incidence of intraoperative awareness. OBJECTIVE The aim of this study is to evaluate the intraoperative and postoperative effects of adjuvant ketamine, when used in combination with general anesthesia. METHODS The study was conducted on the patients referred to Asali hospital for the cesarean section. 100 patients were assigned to two groups. Patients in Group A received thiopental (4 mg / kg) as an anesthetic agent for the surgery whereas; those in group B received thiopental along with 0.5 mg / kg of intravenous ketamine. The effects of ketamine such as, depth of anesthesia, intraoperative and postoperative awareness, vomiting and hallucination were recorded in the questionnaire and data were statistically analyzed using SPSS v25. RESULTS Of 100 patients in group A, 10 of them were not deeply unconscious. 40 patients in group A and 25 in group B had intraoperative awareness. 1 patient in group A and 3 in group B had vomiting and 1 patient in group B was presented with the hallucinations. CONCLUSION Overall use of ketamine is associated with better sedation and no significant side effects with low doses of ketamine, were seen in our study. Comparative studies using other analgesics, with larger sample size are therefore recommended. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.AIMS Development of novel anti-breast cancer agents. BACKGROUND Breast cancer, caused by the development of malignant cells in the breast, is the most common invasive cancer and the second leading cause of cancer death in women after lung cancer. One in eight women worldwide develop breast cancer during their lifetime, and the International Agency for Research on Cancer estimated that breast cancer resulted in 2.1 million new cases and 627,000 deaths in 2018. Anticancer agents are critical for the treatment of breast cancer, but the cost is pretty high mean per patient per month costs of breast cancer were to be $2,896 (median $1,940). Moreover, the increasing emergency of drug-resistant breast cancers and the toxic side effects of the drugs have already put heavy burden on the effective control and eradication of breast cancers. OBJECTIVE The primary objective of this study was to evaluate the potential of bis-isatin scaffolds with alkyl/ether linkers between the two isatin moieties against different human breast cancer cell lines including MCF-7, AU565, MDA-MB-231, MDA-MB-435 and MDA-MB-468 cells. METHOD The bis-isatin scaffolds 4, 8 along with the references Doxorubicin and Cisplatin were evaluated for their in vitro activity against MCF-7, AU565, MDA-MB-231, MDA-MB-435, and MDA-MB-468 human breast cancer cell lines by MTT assay. RESULT The bis-isatin scaffolds 4 and 8 were sensitive to MCF-7, AU565, MDA-MB-231, MDA-MB-435, and MDA-MB-468 human breast cancer cell lines, and the most active compound 4e was no inferior to that of Cisplatin, highlighting the significance of exploring the bis-isatin scaffolds to fight against breast cancers. CONCLUSION The bis-isatin scaffolds are useful templates for the development of novel anticancer agents Other The enriched SAR may set up the direction for the rational design and development of novel bis-isatin scaffolds with higher efficiency. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.AIMS To develop novel anticancer candidates which are sensitive to both drug-sensitive and drug-resistant cancers, a series of 1-[(1R, 2S)-2-fluorocyclopropyl]ciprofloxacin-(4-methyl/phenyl/benzyl-3-aryl)-1,2,4-triazole-5(4H)-thione hybrids were designed, synthesized and evaluated for their anticancer activity. BACKGROUND Chemotherapy is an essential tool for the treatment of cancers, and numerous anticancer agents have been launched for this purpose. However, the clinical outcomes of chemotherapy are usually far from satisfactory due to the side effects and resistance to chemotherapeutic drugs. Thus, it is urgent to develop novel anticancer agents. OBJECTIVE To enrich the anticancer SAR of 1-[(1R, 2S)-2-fluorocyclopropyl]ciprofloxacin-(4-methyl/phenyl/benzyl-3-aryl)-1,2,4-triazole-5(4H)-thione hybrids and develop these hybrids as dual-acting mechanism anticancer agents. METHOD 1-[(1R, 2S)-2-fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H)-thione hybrids were designed, synthesized, and evaluated for in vitro anticancer activity against drug-sensitive lung (A549), breast (MCF-7) cancer cell lines and their drug-resistant counterparts A549/CDDP (cisplatin-resistant), MCF-7/ADM (doxorubicin-resistant) cells. The most active hybrid 7k was selected for further evaluation of its inhibitory activity against topoisomerase II and EGFR. RESULT These hybrids possess equally activity against both drug-sensitive cancer cells and their drug-resistant counterparts, and the majority of them were no inferior to the reference Vorinostat. The mechanistic study revealed that these hybrids could inhibit both topoisomerase II and EGFR, so these hybrids can be developed as dual-acting mechanism anticancer agents. CONCLUSION These hybrids could serve as dual-acting mechanism anticancer candidates to fight against both drug-sensitive and drug-resistant cancers. Other These hybrids could act as lead compounds for further investigations. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo anticancer activity. Hybrid molecules have the potential to enhance efficiency, overcome drug resistance and reduce side effects, and many hybrid molecules are under different phase clinical trials, so hybridization of 1,3,5-triazine with azole may provide valuable therapeutic intervention for the treatment of cancer. Substantial efforts have been made to develop azole-containing 1,3,5-triazine hybrids as novel anticancer agents, and some of them exhibited excellent activity. This review emphasizes azole-containing 1,3,5-triazine hybrids with potential anticancer activity, and the structure-activity relationships as well as the mechanisms of action are also discussed to provide a low-height flying bird's eye view for a comprehensive and target oriented information for the development of this kind of anticancer drugs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Heterocyclic compounds play significant role in various biological processes of human body and many of them are in clinical use due to their diverse, chemical and biological properties. Among these, indole is one of most promising pharmacologically active molecules. Due to its chemical reactivity, indole has been willingly modified to obtain a variety of new lead molecules, which has been successfully utilized to obtained novel drug candidates for the treatment of different pharmacological diseases. Indole-based compounds such as vincristine (Anticancer), reserpine (Antihypertensive), amedalin (Antidepressant) and many more describe the medicinal and pharmacological importance of the indole in uplifting human life. In this review, we compiled various reports on indole derivatives from 2015 onwards and their biological significance including antifungal, antiprotozoal, antiplatelet, anti-Alzheimer's, anti-Parkinson's, antioxidant and anticancer potential. selleck kinase inhibitor In addition, structure activity relationship studies of the different derivatives have been included.