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Gastric contractions are, in part, coordinated by slow-waves. Functional motility disorders are correlated with abnormal slow-wave patterns. Gastric pacing has been attempted in a limited number of studies to correct gastric dysmotility. Integrated electrode arrays capable of pacing and recording slow-wave responses are required.

New flexible surface-contact pacing electrodes (SPE) that can be placed atraumatically to pace and simultaneously map the slow-wave activity in the surrounding area were developed. SPE were applied in pigs in-vivo for gastric pacing along with concurrent high-resolution slow wave mapping as validation. Histology was conducted to assess for tissue damage around the pacing site. SPE were compared against temporary cardiac pacing electrodes (CPE), and hook-shaped pacing electrodes (HPE), for entrainment rate, entrainment threshold, contact quality, and slow-wave propagation patterns.

Pacing with SPE (amplitude 2 mA, pulse width 100 ms) consistently achieved pacemaker initiation. Histological analysis illustrated no significant tissue damage. SPE resulted in a higher rate of entrainment (64%) than CPE (37%) and HPE (24%), with lower entrainment threshold (25% of CPE and 16% of HPE). High resolution mapping showed that there was no significant difference between the initiated slow-wave propagation speed for SPE and CPE (6.8±0.1 vs 6.8±0.2mm/s, P>0.05). However, SPE had higher loss of tissue lead contact quality than CPE (42±16 vs 13±10% over 20min).

Pacing with SPE induced a slow-wave pacemaker site without tissue damage.

SPE offered an atraumatic pacing electrode with a significant reduction of power consumption and placement time compared to impaled electrodes.

SPE offered an atraumatic pacing electrode with a significant reduction of power consumption and placement time compared to impaled electrodes.

Schizophrenia is a severe mental disorder associated with nerobiological deficits. Auditory oddball P300 have been found to be one of the most consistent markers of schizophrenia. The goal of this study is to find quantitative features that can objectively distinguish patients with schizophrenia (SCZs) from healthy controls (HCs) based on their recorded auditory odd-ball P300 electroencephalogram (EEG) data.

Using EEG dataset, we develop a machine learning (ML) algorithm to distinguish 57 SCZs from 66 HCs. The proposed ML algorithm has three steps. In the first step, a brain source localization (BSL) procedure using the linearly constrained minimum variance (LCMV) beamforming approach is employed on EEG signals to extract source waveforms from 30 specified brain regions. In the second step, a method for estimating effective connectivity, referred to as symbolic transfer entropy (STE), is applied to the source waveforms. In the third step the ML algorithm is applied to the STE connectivity matrix to determine whether a set of features can be found that successfully discriminate SCZ from HC.

The findings revealed that the SCZs have significantly higher effective connectivity compared to HCs and the selected STE features could achieve an accuracy of 92.68%, with a sensitivity of 92.98% and specificity of 92.42%.

The findings imply that the extracted features are from the regions that are mainly affected by SCZ and can be used to distinguish SCZs from HCs.

The proposed ML algorithm may prove to be a promising tool for the clinical diagnosis of schizophrenia.

The proposed ML algorithm may prove to be a promising tool for the clinical diagnosis of schizophrenia.

Veterans experience high levels of trauma, psychiatric, and medical conditions that may increase their risk for insomnia. To date, however, no known study has examined the prevalence, risk correlates, and comorbidities of insomnia in a nationally representative sample of veterans.

A nationally representative sample of 4,069 US military veterans completed a survey assessing insomnia severity; military, trauma, medical, and psychiatric histories; and health and psychosocial functioning. Multivariable analyses examined the association between insomnia severity, psychiatric and medical comorbidities, suicidality, and functioning.

A total of 11.4% of veterans screened positive for clinical insomnia and 26.0% for subthreshold insomnia. Greater age and retirement were associated with a lower likelihood of insomnia. Adverse childhood experiences, traumatic life events, lower education and income were associated with greater risk for insomnia. A "dose-response" association was observed for health comorbidities, as they transition from the military.

A variety of behavioral interventions have been shown to improve symptoms of non-rapid eye movement parasomnias. Prior reports have typically examined outcomes of a single behavioral intervention. Sunitinib purchase However, non-rapid eye movement parasomnias may benefit from a multipronged treatment approach similar to that used in the behavioral treatment of other sleep disorders. Through a series of 3 case reports, we demonstrate the utility of a case-conceptualization based, integrative approach to behavioral treatment of adult non-rapid eye movement parasomnias. For all patients (2 with disorders of arousal and 1 with sleep-related eating disorder), symptoms were satisfactorily reduced after 3-6 sessions. Treatment was tailored to each individual, but common elements included education, hypnosis, and identifying and reducing priming factors (eg, stress, insufficient sleep) and precipitating factors (eg, noise or touch from bed partners).

A variety of behavioral interventions have been shown to improve symptoms of non-rapid eye movement parasomnias. Prior reports have typically examined outcomes of a single behavioral intervention. However, non-rapid eye movement parasomnias may benefit from a multipronged treatment approach similar to that used in the behavioral treatment of other sleep disorders. Through a series of 3 case reports, we demonstrate the utility of a case-conceptualization based, integrative approach to behavioral treatment of adult non-rapid eye movement parasomnias. For all patients (2 with disorders of arousal and 1 with sleep-related eating disorder), symptoms were satisfactorily reduced after 3-6 sessions. Treatment was tailored to each individual, but common elements included education, hypnosis, and identifying and reducing priming factors (eg, stress, insufficient sleep) and precipitating factors (eg, noise or touch from bed partners).