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28-.68, large; P = .060-.001); percentage decrease in RPOs after prior accumulated work was the only parameter differentiating U23 and PRO HIGHR, with PRO declining less in relative RPO-1min, RPO-5min, and RPO-20min after 20 to 50kJ·kg-1 (ηp2=.28-.68, large; P = .090-.001).

Superior absolute and relative RPOs characterize HIGHR JUN climbing specialists. Superior fatigue resistance differentiates HIGHR U23 and PRO climbers compared with low ranked, as well as PRO versus U23 climbers.

Superior absolute and relative RPOs characterize HIGHR JUN climbing specialists. Superior fatigue resistance differentiates HIGHR U23 and PRO climbers compared with low ranked, as well as PRO versus U23 climbers.Older adults could experience split falls or feet-forward falls following an unexpected slip in gait due to different neuromuscular vulnerabilities, and different intervention strategies would be required for each type of faller. Thus, this study aimed to investigate the key factors affecting the fall types based on regular gait pattern. A total of 105 healthy older adults who experienced a laboratory-induced slip and fall were included. Their natural walking trial immediately prior to the novel slip trial was analyzed. To identify the factors related to fall type, gait characteristics and demographic factors were determined using univariate logistic regression, and then stepwise logistic regression was conducted to assess the slip-induced fall type based on these factors. The best fall-type prediction model involves gait speed and recovery foot angular velocity, which could predict 70.5% of feet-forward falls and 86.9% of split falls. Body mass index was also a crucial fall-type prediction with an overall prediction accuracy of 70.5%. Along with gait parameters, 84.1% of feet-forward falls and 78.7% of split falls could be predicted. The findings in this study revealed the determinators related to fall types, which enhances our knowledge of the mechanism associated to slip-induced fall and would be helpful for the development of tailored interventions for slip-induced fall prevention.The aim of this study was to classify and identify young swimmers' performance, and biomechanical determinant factors, and understand if both sexes can be clustered together. Thirty-eight swimmers of national level (22 boys 15.92 ± 0.75 years and 16 girls 14.99 ± 1.06 years) were assessed. Performance (swim speed at front crawl stroke) and a set of kinematic, efficiency, kinetic, and hydrodynamic variables were measured. Variables related to kinetics and efficiency (p less then .001) were the ones that better discriminated the clusters. All three clusters included girls. Based on the interaction of these determinant factors, there are girls who can train together with boys. These findings indicate that not understanding the importance of the interplay between such determinants may lead to performance suppression in girls.

This study aimed to evaluate the predictive value of lymph node yield (LNY) for survival outcomes according to tumor response after preoperative chemoradiotherapy (PCRT) in patients with rectal cancer.

This study was a retrospective study conducted in a tertiary center. A total of 1,240 patients with clinical stage II or III rectal cancer who underwent curative resection after PCRT between 2007 and 2016 were included. selleck chemicals Patients were categorized into the good response group (tumor regression grade [TRG], 0-1) or poor response group (TRG, 2-3). Propensity score matching was performed for age, sex, and pathologic stage between LNY of ≥12 and LNY of <12 within tumor response group. The primary outcome was 5-year disease-free survival (DFS) and overall survival (OS).

LNY and positive lymph nodes were inversely correlated with TRG. In good responders, 5-year DFS and 5-year OS of patients with LNY of <12 were better than those with LNY of ≥12, but there was no statistical significance. In poor responders, the LNY of <12 group had worse survival outcomes than the LNY of ≥12 group, but there was also no statistical significance. LNY of ≥12 was not associated with DFS and OS in multivariate analysis.

LNY of <12 showed contrasting outcomes between the good and poor responders in 5-year DFS and OS. LNY of 12 may not imply adequate oncologic surgery or proper staging in rectal cancer patients treated by PCRT. Furthermore, a decrease in LNY should be comprehended differently according to tumor response.

LNY of less then 12 showed contrasting outcomes between the good and poor responders in 5-year DFS and OS. LNY of 12 may not imply adequate oncologic surgery or proper staging in rectal cancer patients treated by PCRT. Furthermore, a decrease in LNY should be comprehended differently according to tumor response.The mechanism of nasal airflow perception remains little known. It is currently believed that the main mechanism for perceiving nasal patency is to activate transient receptor potential melastatin subtype 8. Computer fluent dynamics show that increased airflow and heat flux are associated with higher subjective scores. Similarly, physical measurements of the nasal cavity using a temperature probe show a correlation between the lower nasal mucosa temperature and better results. Trigeminal function detection also indirectly confirms this. This literature review aimed to explore the role of nasal mucosal temperature change in the subjective perception of nasal patency and the secondary aim was to appraise the relevant evidence about the mechanism.The main causes of hypoparathyroidism are unintentional parathyroidectomy and/or impaired blood supply. Therefore, accurate identification and preservation of parathyroid glands in situ during thyroid or parathyroid surgery has become one of the problems that plague endocrine surgeons. In recent years, near-infrared autofluorescence imaging technology has gradually attracted more and more attention from surgeons because of its simplicity, safety, accuracy, real-time, no-contrast agent, and non-invasiveness. This article reviews the development history, clinical application, and application prospects of the parathyroid gland autofluorescence imaging technology in recent years.With the incidence of head and neck squamous cell carcinoma increasing year by year and the epidemiological trend changes, the research on risk factors of head and neck squamous cell carcinoma and its primary prevention has attracted more and more attention. At present, many risk factors of head and neck squamous cell carcinoma have been studied, which can be divided into genetic factors and non-genetic factors. Among the non-genetic factors, viral infection （HPV virus, Epstein-Barr virus）, lifestyle （smoking, drinking, diet, chewing betel nut）, social behavior factors, immunosuppression, occupational exposure, and other factors are closely related to HNSCC incidence. In this paper, the research progress of HNSCC related risk factors is reviewed to provide evidence for the identification of the risk of head and neck squamous cell carcinoma and reduce the risk behaviors to reduce the incidence of head and neck squamous cell carcinoma.Trichoepithelioma is a kind of rare benign tumor of the skin that occurs in direct sunlight and is usually small. Large solitary trichoepithelioma behind the ear is rare. The pathological result of this patient was fibroproliferative trichoepithelioma. This type of tumor is rare and has no specific tumor markers. Diagnosis can be decided based on its histological characteristics. Combined with the appearance and histological characteristics of other types of trichoepithelioma, it can be concluded that this tumor is a special type of connective tissue hyperplastic trichoepithelioma.A clinical case of ectopic thyroid carcinoma in front of hyoid bone was reported in this paper. The patient, a 17-year-old female, presented with an enlarging neck mass of 1-week history. Physical examination revealed a 3 cm×2 cm neck mass in front of the hyoid bone. Ultrasonographic depicted as a cystic solid mixed echogenic mass with punctate strong echogenicity. CT scan showed a cystic-solid mass in front of the hyoid bone with punctate calcifications. The patient was misdiagnosed as a thyroglossal duct cyst and underwent surgery. The final pathological diagnosis was papillary thyroid carcinoma with cyst formation.ObjectiveTo investigate the expression of Vitamin C in adult patients with chronic rhinosinusitis（CRS） and its correlation with immune function. MethodsA total of 315 patients who underwent nasal endoscopic surgery at the Department of Otolaryngology Head and Neck Surgery and undergoing nasal endoscopic surgery were collected from Renmin Hospital of Wuhan University from May 2018 to June 2020, including 207 CRS patients, who were divided into CRS without nasal polyps（CRSsNP） group（110 cases） and CRS with nasal polyps（CRSwNP） group（97 cases）; 108 patients with nasal septum correction were selected as the control group. All patients underwent serum Vitamin A, C, D, and E tests. Among them, 107 patients（39 in the control group, 35 in the CRSsNP group, and 33 in the CRSwNP group） were treated with serum IL-2, TNF-α, IFN-γ, IL-4, IL-5, IL-6, IL-10, etc. Detection of cytokines and immune protein levels such as IgA, IgM, IgG, C3, and C4. ResultsThe serum levels of Vitamin C and IL-10 in the CRSwNP group were significantly lower than those in the control group（P less then 0.05）, and the serum C4 level was significantly higher（P less then 0.05）; the serum Vitamin C level decreased with the level of IL-10, the decline is positively correlated, while negatively correlated with C4 levels; CRSsNP patients also had lower Vitamin C levels and higher C3 and C4 levels. ConclusionThe Vitamin C level in adult patients with CRS is lower than that in the normal population, and the level of C4 is higher; the level of IL-10 in patients with CRSwNP is lower; Vitamin C affects the immune balance and antioxidant level of patients, and in the pathogenesis of CRS and nasal polyps play a certain role.ObjectiveThrough analysis of the sound energy absorbance of wideband acoustic immittance to provide a basis for differential diagnosis of adult acquired secondary cholesteatoma of the middle ear and patients with chronic suppurative otitis media（CSOM）. Methods38 cases of cholesteatoma and 40 cases of CSOM admitted to the Department of Otolaryngology, Affiliated Hospital of Xuzhou Medical University from September 2020 to December 2021 were selected as the research group, and 30 cases （60 ears） of normal adults were selected as the control group. A total of 16 frequency points were selected, and the energy absorbance of wideband acoustic immittance was taken as the research parameter. The characteristics of energy absorbance under ambient pressure among the three are compared. Then the ROC in the cholesteatoma group was drawn, and by calculating the AUC, the Cut-off values and the corresponding sensitivity and specificity were found. ResultsThe energy absorbance in CSOM group at 1100-5700 Hz and the cholesteatoma group at 560-5700 Hz was lower than that in the control group, and the difference in some frequency bands was statistically significant. The energy absorbance in the cholesteatoma group at 226-7100 Hz was lower than that in the CSOM group, and the difference between the two groups in many frequency points was statistically significant. The ROC in the research group was drawn and it was found that the AUC in the 560, 710, 890, and 4500 bands was > 0.5, and in the other bands was > 0.7（P less then 0.05）. The AUC in the 2800 Hz was the largest （0.78）, the Cut-off value was 0.31, the corresponding sensitivity was 78.38%, specificity was 73.33%. ConclusionWideband acoustic immittance can be used as an auxiliary method for the differential diagnosis of adult-acquired secondary cholesteatoma of the middle ear and chronic suppurative otitis media in adults.