Templetonsheridan2904

The 1-year and 3-year DFS rates were 75.00% and 70.83% in group A1, 70.59% and 58.82% in group A2, 46.67% and 40.00% in group A3, with significant difference(P less then 0.05). The 1-year and 3-year OS rates were 83.33% and 75.00% in group A1, 73.53% and 50.00% in group A2, 46.67% and 40.00% in group A3 , with significant difference(P less then 0.05). In group A3, there were 4 cases (13.33%) of low-risk TP53 mutation (LR), 12 cases (40.00%) of high-risk TP53 mutation (HR), 4 cases(13.33%) of wild-type TP53 mutation (Wt), and 10 cases(33.33%) of other mutations. HR mutation and other mutations occurred more frequently than other types(P less then 0.05). Smoking, primary lesion size, wild type/low risk and high risk/others were correlated with ECS(P less then 0.05). CONCLUSIONS ECS is an important marker of DFS and OS in OSCC patients, and high-risk mutations were common in ECS, indicating a certain correlation between high-risk mutations of TP53 and ECS in OSCC.PURPOSE To evaluate the treatment effect of topical doxycycline on avulsed permanent teeth compared with normal saline. METHODS A total of 44 avulsed teeth from 38 patients (22 boys and 16 girls, aged 7-14 years) were recruited. Twenty-one teeth in group A were treated with doxycycline for 5 min before replantation while 23 teeth in group B were treated with saline solution. All participants were followed up for at least 12 months. GSH nmr The clinical outcome differences between 2 groups was evaluated by Mann-Whitney U test. RESULTS In group A, 18 teeth were found pulp necrosis, 3 with infection-related resorption, 13 with ankylosis-related resorption and 6 were extracted. In group B, 16 were diagnosed with pulp necrosis, 4 with infection-related resorption, 12 with ankylosis-related resorption and 7 were extracted. No significant differences were found between the two groups on pulp survival and periodontal healing. CONCLUSIONS Compared with treatment with normal saline, avulsed permanent teeth treated with doxycycline did not show a better clinical outcome.PURPOSE To evaluate the clinical effects of periodontal therapy for combined periodontal-pulpal lesions. METHODS One hundred and nine patients with periodontal-pulpal lesions were included in this study, with total 120 teeth. All the teeth were treated by perfect root canal therapy, and than divided into group A and B. Group A was treated with periodontal therapy (60 teeth). After 2 weeks of root canal therapy, basic periodontal therapy was performed. After 6 weeks, patients with more than 5 mm periodontal pockets and bleeding after probe were treated with valvuloplasty. Group B underwent non-periodontal treatment (60 teeth), root canal therapy and supragingival scaling alone. The patients were followed up for 3, 6, 12 and 24 months after operation. SPSS 22.0 software package was used to analyze the indexes at initial diagnosis and 24 months after operation. RESULTS In group A, the depth of periodontal pockets was significantly reduced before and after PD, from(5.966±1.877) mm to(5.133±1.935) mm. The periodontal pocket depth of group B was significantly increased before and after operation, from(5.533±1.856) mm to (6.167±1.927) mm. The degree of tooth mobility (TM) before operation was similar between the two groups (P>0.05). Two years after operation, the degree of TM in group A was significantly lower than that in group B (P0.05). The alveolar bone resorption in group B changed significantly before and after operation (P less then 0.05). CONCLUSIONS Root canal therapy combined with periodontal therapy for combined periodontal-pulpal lesions can achieve good results. It can be widely used in clinic.PURPOSE To observe the effects of immediate implantation combined with high-speed turbine minimally invasive technology and traditional technology on postoperative analgesia, mouth opening and alveolar bone resorption after removal of complex impacted teeth. METHODS Eighty patients with impacted teeth treated in our hospital from January 2014 to December 2018 were randomly divided into 2 groups experimental group and control group with 40 cases in each group. Patients in the experimental group were treated with high-speed turbine minimally invasive surgery combined with immediate implantation, while patients in the control group were treated with traditional surgery combined with immediate implantation. Differences in alveolar bone resorption, pain, swelling, limited mouth opening, intact extraction socket and complications were compared between the two groups. SPSS 19.0 software package was used to perform statistical analysis. RESULTS Three months after operation, the implant height of the maxillary anterior teeth, maxillary molar, mandibular anterior teeth and mandibular molar areas in the experimental group was significantly lower than that in the control group. One day after operation, the VAS score of the experimental group was significantly lower than that of the control group (P0.05); but intact extraction socket, swelling degree and mouth opening limitation of the experimental group were significantly lower than those of the control group. The root fracture, adjacent teeth loosening, gingival tear, lingual bone plate fracture of the experimental group were significantly lower than those of the control group. CONCLUSIONS High-speed turbine minimally invasive treatment combined with immediate implantation after extraction of complex impacted teeth can significantly increase alveolar bone resorption, relieve swelling and preserve intact extraction socket, reduce pain and complications after operation. It is recommended to be popularized in clinic.PURPOSE This study was aimed to use Q methodology to find out why parents of cleft lip and/or palate (CLP) patients want their children to undergo orthodontic treatment. METHODS Q methodology involved five phases.①concourse, collecting all viewpoints from CLP patients' parents on seeking orthodontic treatment. ②Q sample, Selecting 36 items from the concourse. ③P sample, forty varieties of parents whose children were CLP patients and want to have braces. ④Q sort, participant- ranked statements (Q sample) in order of relative significance using an enforced distribution grid (Q grid). ⑤analysis using PQMehtod 2.35 vision to analyze the data. RESTULTS Three factors were identified as representing the most widespread views of the majority of the parents. Group 1 consisted of parents of 13 CLP patients marked as factor 1 responsibility as parents. The parents of 8 participants made up group 2 designated as factor 2 parents' anxiety for their children's wellbeing. Group 3 was made up of parents of 9 CLP patients marked as factor 3 oral function.