Mcfarlandphillips3760

Nonreciprocity, the defining characteristic of isolators, circulators, and a wealth of other applications in radio/microwave communications technologies, is generally difficult to achieve as most physical systems incorporate symmetries that prevent the effect. In particular, acoustic waves are an important medium for information transport, but they are inherently symmetric in time. In this work, we report giant nonreciprocity in the transmission of surface acoustic waves (SAWs) on lithium niobate substrate coated with ferromagnet/insulator/ferromagnet (FeGaB/Al2O3/FeGaB) multilayer structure. We exploit this structure with a unique asymmetric band diagram and expand on magnetoelastic coupling theory to show how the magnetic bands couple with acoustic waves only in a single direction. We measure 48.4-dB (power ratio of 169,200) isolation that outperforms current state-of-the-art microwave isolator devices in a previously unidentified acoustic wave system that facilitates unprecedented size, weight, and power reduction. In addition, these results offer a promising platform to study nonreciprocal SAW devices.The biophysical and biochemical properties of live tissues are important in the context of development and disease. SB290157 antagonist Methods for evaluating these properties typically involve destroying the tissue or require specialized technology and complicated analyses. Here, we present a novel, noninvasive methodology for determining the spatial distribution of tissue features within embryos, making use of nondirectionally migrating cells and software we termed "Landscape," which performs automatized high-throughput three-dimensional image registration. Using the live migrating cells as bioprobes, we identified structures within the zebrafish embryo that affect the distribution of the cells and studied one such structure constituting a physical barrier, which, in turn, influences amoeboid cell polarity. Overall, this work provides a unique approach for detecting tissue properties without interfering with animal's development. In addition, Landscape allows for integrating data from multiple samples, providing detailed and reliable quantitative evaluation of variable biological phenotypes in different organisms.Here, we selectively target pancreatic ductal adenocarcinoma (PDAC) cells harboring a hemizygous gene essential for cell growth. MYB binding protein 1A (MYBBP1A), encoding a chromatin-bound protein, is hemizygous in most of the PDAC due to a chromosome 17p deletion that also spans TP53 We find that hemizygous MYBBP1A loss in isogenic PDAC cells promotes tumorigenesis but, paradoxically, homozygous MYBBP1A loss is associated with impaired cell growth and decreased tumorigenesis. Poly-adenosine 5'-diphosphate-ribose polymerase 1 (PARP1) interacts with MYBBP1A and displaces it from chromatin. Small molecules, such as olaparib, that trap PARP1 to chromatin are able to evict the minimal pool of chromatin-bound MYBBP1A protein in MYBBP1A hemizygous cells and impair cell growth, greater than its impact on wild-type cells. Our findings reveal how a cell essential gene with one allele lost in cancer cells can be preferentially susceptible to a specific molecular therapy, when compared to wild-type cells.Seasonal fluctuations in food prices reflect interactions between climate and society, measuring the degree to which predictable patterns of crop growth and harvest are offset by storage and trade. Previous research on seasonality in food systems has focused on specific commodities. This study accounts for substitution between items to meet nutritional needs, computing seasonal variation in local food environments using monthly retail prices for 191 items across Ethiopia, Malawi, and Tanzania from 2002 through 2016. We computed over 25,000 least-cost diets meeting nutrient requirements at each market every month and then measured the magnitude and timing of seasonality in diet costs. We found significant intensity in Malawi, Tanzania, and Ethiopia (10.0, 6.3, and 4.0%, respectively), driven primarily by synchronized price rises for nutrient-dense foods. Results provide a metric to map nutritional security, pointing to opportunities for more targeted investments to improve the year-round delivery of nutrients.Chiral spin textures are of considerable interest for applications in spintronics. It has recently been shown that magnetic materials with D2d symmetry can sustain several distinct spin textures. Here, we show, using Lorentz transmission electron microscopy, that single and double chains of antiskyrmions can be generated at room temperature in nanostripes less than 0.5 μm in width formed from the D2d Heusler compound Mn1.4Pt0.9Pd0.1Sn. Typically, truncated helical spin textures are formed in low magnetic fields, whose edges are terminated by half antiskyrmions. These evolve into chains of antiskyrmions with increasing magnetic field. Single chains of these objects are located in the middle of the nanostripes even when the stripes are much wider than the antiskyrmions. Moreover, the chains can even include elliptical Bloch skyrmions depending on details of the applied magnetic field history. These findings make D2d materials special and highly interesting for applications such as magnetic racetrack memory storage devices.Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are early events in Alzheimer's disease (AD) that lead to cognitive deficits; however, the underlying mechanism remains unknown. Here, we find that mature OLs in both AD patients and an AD mouse model undergo NLR family pyrin domain containing 3 (NLRP3)-dependent Gasdermin D-associated inflammatory injury, concomitant with demyelination and axonal degeneration. The mature OL-specific knockdown of dynamin-related protein 1 (Drp1; a mitochondrial fission guanosine triphosphatase) abolishes NLRP3 inflammasome activation, corrects myelin loss, and improves cognitive ability in AD mice. Drp1 hyperactivation in mature OLs induces a glycolytic defect in AD models by inhibiting hexokinase 1 (HK1; a mitochondrial enzyme that initiates glycolysis), which triggers NLRP3-associated inflammation. These findings suggest that OL glycolytic deficiency plays a causal role in AD development. The Drp1-HK1-NLRP3 signaling axis may be a key mechanism and therapeutic target for white matter degeneration in AD.