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eated according to the SIOP protocol. selleck products Systematic LN sampling to reduce the rate of false negatives is still strongly recommended.
Our cohort presented with a relatively low LNY compared to standard recommendations. Our EFS, however, remained acceptable. Multivariate analysis would be necessary to determine the actual role of LN sampling as an isolated prognostic factor in unilateral WT.
Our cohort presented with a relatively low LNY compared to standard recommendations. Our EFS, however, remained acceptable. Multivariate analysis would be necessary to determine the actual role of LN sampling as an isolated prognostic factor in unilateral WT.
Little has been reported to date on the instillation of antimicrobials directly into the bladder in children. Children with complex urinary tract anomalies struggle frequently with recurrent urinary tract infections (UTI), with frequent emergence of antibiotic resistance. Gentamicin bladder instillation to treat and prevent UTI was described in children since 2006.
We adopted gentamicin bladder instillation in 2016 and evaluate herein our intermediate-term experience with it.
This study is a retrospective review of a prospectively initiated database and a clinical audit of our practice. The gentamicin bladder instillation was employed in 24 cases. A treatment regime was initiated for symptomatic documented UTI when resistance patterns precluded an oral alternative (14 cases), avoiding hospitalisation for parenteral antibiotics. A prophylaxis regime (19 cases-including 9 of the 14 who received an initial treatment regime) followed at least one breakthrough UTI while receiving oral prophylactic antibioticx lower urinary tract abnormalities (see Summary Figure). Concerns regarding systemic absorption, nephrotoxicity or ototoxicity were investigated and safety ensured. Limitations include being a small series of non-identical pathologies, albeit categorically similar and being a single-arm study, however, statistical significance was proven descriptively and analytically.
In selected cases and with the appropriate specialist support and logistics, intravesical gentamicin instillation is well-tolerated and safe to treat and/or prevent urinary tract infections in pateints with complex bladder conditions and lower urinary tract pathologies.
In selected cases and with the appropriate specialist support and logistics, intravesical gentamicin instillation is well-tolerated and safe to treat and/or prevent urinary tract infections in pateints with complex bladder conditions and lower urinary tract pathologies.
Vesicoureteral reflux is a common pediatric urologic condition that often has several reasonable treatment options depending on condition severity. In order to choose the best treatment for their child, parents are expected to make judgements that weigh attributes such as treatment cost, effectiveness, and complication rate. Prior research has shown that factors such as treating hospital and surgeon also influence patient treatment choice.
This study evaluates parental preferences for reflux treatment using profile case best-worst scaling, an emerging technique in both urologic and health care preference estimation. The study also uses latent class analysis (LCA) to identify parental sub-classes with different preferences.
Data were collected from a community sample of parents via a multimedia best-worst scaling survey instrument published to Amazon's Mechanical Turk online community. After extensive review of the literature, reflux attributes and attribute levels were selected to correspond with availabutes to parents, though parents likely have heterogenous treatment preference structures. Shared parent-physician decision-making that incorporates parental preferences will likely allow more effective, targeted decision-making in the future.
In this community-based sample, high treatment effectiveness and low complication rate were the most desirable treatment attributes to parents, though parents likely have heterogenous treatment preference structures. Shared parent-physician decision-making that incorporates parental preferences will likely allow more effective, targeted decision-making in the future.This research evaluated acute and subacute toxicity of aqueous and methanolic extract from stem bark of Garcinia huillensis Baker, a plant used in Congolese traditional medicine against urogenital schistosomiasis. The acute toxicity is evaluated on guinea pigs by single oral administration of 1500, 2000, 2500, 3000 and 3500mg/kg of body weight of extracts based on the method described by protocol 423 of the Organization for Cooperation and Economic Development. Subacute toxicity is assessed after 28 days after daily administration of 4.5, 45, 450 and 1500mg/kg of body weight of extracts. Weight evolution, hematological and biochemical parameters of the guinea pigs that survived were analyzed and compared with those of the controls. Acute oral toxicity data were used to calculate the LD50 of 2717.39 and 2625.00mg/kg bw for the aqueous and methanolic extract, respectively. Some signs of intoxication were noted, and certain haematological and biochemical parameters analyzed in the treated guinea pigs sometimes presented statistically significant differences compared to those of the controls. The minimum tolerated dose (1652.17mg/kg bw) found for the aqueous extract is far greater than the therapeutic dose administered by traditional therapists (4.5mg). Thus, the study shows that the stem bark of G. huillensis would be moderately toxic and would present a good margin of safety under the conditions of our experimentation, which would justify the non-toxic use of the plant under the traditional conditions of preparation and oral administration.
Ethics are at the heart of pharmacy practice.
This is a literature review. The main objective is to carry out a review of studies relating on the evaluation of ethics in pharmacy practice. Documentary research on Pubmed was carried out from 1990 to 2020. All studies relating to pharmaceutical ethics that may be applied to the pharmacy practice in pharmacies or in health establishments and that conducted a qualitative or quantitative evaluation of pharmaceutical ethics (e.g. surveying pharmacists or pharmacy students, using a measurement tool, quantifying or qualifying a perception or behavior) were included.
The studies come mainly from Anglo-Saxon countries (29/38). Studies related to pharmacy practice mainly target pharmacists (n = 27) and pharmacy students (n = 16) and more often have a quantitative component of (n = 28). The main ethical dilemmas observed dealt with emergency oral contraception (EOC), voluntary termination of pregnancy with drugs, euthanasia, commercial practices of the pharmaceutical industry, refusal to dispense a prescription in a broader context and plagiarism or dishonesty in academic settings.
