Anthonypalmer7625

Background Brotizolam is a sedative-hypnotic thienotriazolodiazepine that is a benzodiazepine analog used for debilitating insomnia. Anxiety, depression, and sleep disorders occur in about 15% of pregnant and lactating women; however, no studies have examined brotizolam transfer across the placenta or its excretion into breast milk. In this case report, we assessed brotizolam concentrations in maternal and neonatal blood, cord blood, and breast milk. Materials and Methods Brotizolam concentrations in maternal serum, breast milk, cord blood, and neonatal serum were measured while the mother was taking oral brotizolam 0.25 mg once daily. Case Report A 28-year-old woman diagnosed with bipolar II disorder received brotizolam during pregnancy (28-40 weeks' gestational age) and lactation, along with sertraline, alprazolam, and trazodone. A male infant weighing 3,412 g was born at 40 weeks of gestation. Neonatal abstinence syndrome manifested as fever, limb tremor, and central cyanosis, requiring oxygenation and intravenous phenobarbital administration for 4 days. No pulmonary dysfunction or birth defects were detected. Brotizolam concentrations in maternal serum at 7.0 and 14.0 hours after maternal dosing were 0.51 and 0.22 ng/mL, respectively. Brotizolam was not detected in cord blood or infant serum 9.2 hours after maternal dosing. The brotizolam concentration in breast milk collected 7.1 hours after maternal dosing was 0.12 ng/mL. The infant developed normally, with no drug-related adverse effects at the 1-, 3-, or 6-month postpartum checkups. Conclusion Brotizolam transfer into placenta and breast milk was negligible. Further studies should assess the safety of brotizolam in fetuses and breastfed infants.This corrects the article DOI 10.1103/PhysRevLett.125.048102.Yu-Shiba-Rusinov (YSR) bound states appear when a magnetic atom interacts with a superconductor. Here, we report on spin-resolved spectroscopic studies of YSR states related with Fe atoms deposited on the surface of the topological superconductor FeTe_0.55Se_0.45 using a spin-polarized scanning tunneling microscope. We clearly identify the spin signature of pairs of YSR bound states at finite energies within the superconducting gap having opposite spin polarization as theoretically predicted. In addition, we also observe zero-energy bound states for some of the adsorbed Fe atoms. In this case, a spin signature is found to be absent indicating the absence of Majorana bound states associated with Fe adatoms on FeTe_0.55Se_0.45.We used density functional theory calculations to investigate the physical origin of the mechanochemical response of material interfaces. Our results show that the mechanochemical response can be decomposed into the contribution from the interface itself (deformation of interfacial bonds) and a contribution from the underlying solid. The relative contributions depend on the stiffness of these regions and the contact geometry, which affects the stress distribution within the bulk region. We demonstrate that, contrary to what is commonly assumed, the contribution to the activation volume from the elastic deformation of the surrounding bulk is significant and, in some case, may be dominant. We also show that the activation volume and the mechanochemical response of interfaces should be finite due to the effects on the stiffness and stress distribution within the near-surface bulk region. Our results indicate that the large range of activation volumes measured in the previous experiments even for the same material system might originate from the different degrees of contributions probed from the bulk vs interface.Detector backaction can be completely evaded when the state of a one-electron quantum cyclotron is detected, but it nonetheless significantly broadens the quantum-jump resonance line shapes from which the cyclotron frequency can be deduced. This limits the accuracy with which the electron magnetic moment can be determined to test the standard model's most precise prediction. A steady-state solution to a master equation, the first quantum calculation for the open quantum cyclotron system, illustrates a method to circumvent the detection backaction upon the measured frequency.A recently developed formula for the Hall coefficient [A. Auerbach, Phys. Rev. Lett. 121, 066601 (2018)PRLTAO0031-900710.1103/PhysRevLett.121.066601] is applied to nodal line and Weyl semimetals (including graphene) and to spin-orbit split semiconductor bands in two and three dimensions. The calculation reduces to a ratio of two equilibrium susceptibilities, where corrections are negligible at weak disorder. Defactinib price Deviations from Drude's inverse carrier density are associated with band degeneracies, Fermi surface topology, and interband currents. Experiments which can measure these deviations are proposed.The Heisenberg scaling, which scales as N^-1 in terms of the number of particles or T^-1 in terms of the evolution time, serves as a fundamental limit in quantum metrology. Better scalings, dubbed as "super-Heisenberg scaling," however, can also arise when the generator of the parameter involves many-body interactions or when it is time dependent. All these different scalings can actually be seen as manifestations of the Heisenberg uncertainty relations. While there is only one best scaling in the single-parameter quantum metrology, different scalings can coexist for the estimation of multiple parameters, which can be characterized by multiple Heisenberg uncertainty relations. We demonstrate the coexistence of two different scalings via the simultaneous estimation of the magnitude and frequency of a field where the best precisions, characterized by two Heisenberg uncertainty relations, scale as T^-1 and T^-2, respectively (in terms of the standard deviation). We show that the simultaneous saturation of two Heisenberg uncertainty relations can be achieved by the optimal protocol, which prepares the optimal probe state, implements the optimal control, and performs the optimal measurement. The optimal protocol is experimentally implemented on an optical platform that demonstrates the saturation of the two Heisenberg uncertainty relations simultaneously, with up to five controls. As the first demonstration of simultaneously achieving two different Heisenberg scalings, our study deepens the understanding on the connection between the precision limit and the uncertainty relations, which has wide implications in practical applications of multiparameter quantum estimation.We study an active matter system comprised of magnetic microswimmers confined in a microfluidic channel and show that it exhibits a new type of self-organized behavior. Combining analytical techniques and Brownian dynamics simulations, we demonstrate how the interplay of nonequilibrium activity, external driving, and magnetic interactions leads to the condensation of swimmers at the center of the channel via a nonequilibrium phase transition that is formally akin to Bose-Einstein condensation. We find that the effective dynamics of the microswimmers can be mapped onto a diffusivity-edge problem, and use the mapping to build a generalized thermodynamic framework, which is verified by a parameter-free comparison with our simulations. Our work reveals how driven active matter has the potential to generate exotic classical nonequilibrium phases of matter with traits that are analogous to those observed in quantum systems.Gene expression is a stochastic process. Despite the increase of protein numbers in growing cells, the protein concentrations are often found to be confined within small ranges throughout the cell cycle. Generally, the noise in protein concentration can be decomposed into an intrinsic and an extrinsic component, where the former vanishes for high expression levels. Considering the time trajectory of protein concentration as a random walker in the concentration space, an effective restoring force (with a corresponding "spring constant") must exist to prevent the divergence of concentration due to random fluctuations. In this work, we prove that the magnitude of the effective spring constant is directly related to the fraction of intrinsic noise in the total protein concentration noise. We show that one can infer the magnitude of intrinsic, extrinsic, and measurement noises of gene expression solely based on time-resolved data of protein concentration, without any a priori knowledge of the underlying gene expression dynamics. We apply this method to experimental data of single-cell bacterial gene expression. The results allow us to estimate the average copy numbers and the translation burst parameters of the studied proteins.We investigate the impact of phonon excitations on the photoexcited carrier dynamics in a lead-halide perovskite CH_3NH_3PbI_3, which hosts unique low-energy phonons that can be directly excited by terahertz pulses. Our time-resolved photoluminescence measurements reveal that strong terahertz excitation prolongs the cooling time of hot carriers, providing direct evidence for the hot-phonon bottleneck effect. In contrast to the previous studies where phonons are treated as a passive heat bath, our results demonstrate that phonon excitation can significantly perturb the carrier relaxation dynamics in halide perovskites through the coupling between transverse- and longitudinal-optical phonons.We experimentally study the thermoelectrical signature of individual skyrmions in chiral Pt/Co/Ru multilayers. Using a combination of controlled nucleation, single skyrmion annihilation, and magnetic field dependent measurements the thermoelectric signature of individual skyrmions is characterized. The observed signature is explained by the anomalous Nernst effect of the skyrmion's spin structure. Possible topological contributions to the observed thermoelectrical signature are discussed. Such thermoelectrical characterization allows for noninvasive detection and counting of skyrmions and enables fundamental studies of topological thermoelectric effects on the nanoscale.We establish the appearance of a qualitatively new type of spin liquid with emergent exceptional points when coupling to the environment. We consider an open system of the Kitaev honeycomb model generically coupled to an external environment. In extended parameter regimes, the Dirac points of the emergent Majorana fermions from the original model are split into exceptional points with Fermi arcs connecting them. In glaring contrast to the original gapless phase of the honeycomb model that requires time-reversal symmetry, this new phase is stable against all perturbations. The system also displays a large sensitivity to boundary conditions resulting from the non-Hermitian skin effect with telltale experimental consequences. Our results point to the emergence of new classes of spin liquids in open systems that might be generically realized due to unavoidable couplings with the environment.We calculate the axion emission rate from reactions involving thermal pions in matter encountered in supernovae and neutron star mergers, identify unique spectral features, and explore their implications for astrophysics and particle physics. We find that it is about 2-5 times larger than nucleon-nucleon bremsstrahlung, which in past studies was considered to be the dominant process. The axion spectrum is also found be much harder. Together, the larger rates and higher axion energies imply a stronger bound on the mass of the QCD axion and better prospects for direct detection in a large underground neutrino detector from a nearby galactic supernova.