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Among numerous viruses that infect honey bees (Apis mellifera), Israeli acute paralysis virus (IAPV) can be linked to severe honey bee health problems. Breeding for virus resistance may improve honey bee health. To evaluate the potential for this approach, we compared the survival of IAPV infection among stocks from the U.S. We complemented the survival analysis with a survey of existing viruses in these stocks and assessing constitutive and induced expression of immune genes. Worker offspring from selected queens in a common apiary were inoculated with IAPV by topical applications after emergence to assess subsequent survival. Differences among stocks were small compared to variation within stocks, indicating the potential for improving honey bee survival of virus infections in all stocks. A positive relation between worker survival and virus load among stocks further suggested that honey bees may be able to adapt to better cope with viruses, while our molecular studies indicate that toll-6 may be related to survival differences among virus-infected worker bees. Together, these findings highlight the importance of viruses in queen breeding operations and provide a promising starting point for the quest to improve honey bee health by selectively breeding stock to be better able to survive virus infections.The cigarette beetle, Lasioderma serricorne F. (Coleoptera Anobiidae) is an important food storage pest affecting the tobacco industry and is increasingly impacting museums and herbaria. Monitoring methods make use of pheromone traps which can be implemented using chili fruit powder. The objective of this study was to assess the response of L. serricorne to the volatile organic compounds (VOCs) from different chili powders in order to identify the main semiochemicals involved in this attraction. Volatiles emitted by Capsicum annuum, C. frutescens, and C. chinense dried fruit powders were tested in an olfactometer and collected and analyzed using SPME and GC-MS. Results indicated that C. annuum and C. frutescens VOCs elicit attraction toward L. serricorne adults in olfactometer, while C. chinense VOCs elicit no attraction. Chemicals analysis showed a higher presence of polar compounds in the VOCs of C. annuum and C. frutescens compared to C. chinense, with α-ionone and β-ionone being more abundant in the attractive species. Further olfactometer bioassays indicated that both α-ionone and β-ionone elicit attraction, suggesting that these compounds are candidates as synergistic attractants in pheromone monitoring traps for L. serricorne.Dilated cardiomyopathy (DCM) is the leading indication for heart transplantation. TTN gene truncating mutations account for about 25% of familial DCM cases and for 18% of sporadic DCM cases. The clinical relevance of specific variants in TTN has been difficult to determine because of the sheer size of the protein for which TTN encodes, as well as existing extensive genetic variation. Clinicians should communicate novel clinically-relevant variants and genotype-phenotype associations, so that animal studies evaluating the molecular mechanisms are always conducted with a focus on clinical significance. In the present study, we report for the first time the novel truncating heterozygous variant NM_001256850.1c.72777_72783del (p.Phe24259Leufs*51) in the TTN gene and its association with DCM in a family with sudden death. This variant occurs in the A-band region of the sarcomere, in a known mutational hotspot of the gene. Truncating titin variants that occur in this region are the most common cause of DCM and have been rarely reported in asymptomatic individuals, differently from other pathogenic TTN gene variants. Further studies are warranted to better understand this particular clinically-relevant variant.In this review, we address the interaction between abscisic acid (ABA) and gibberellins (GAs) in regulating non-climacteric fruit development and maturation at the molecular level. selleck products We review the interplay of both plant growth regulators in regulating these processes in several fruit of economic importance such as grape berries, strawberry, and citrus, and show how understanding this interaction has resulted in useful agronomic management techniques. We then relate the interplay of both hormones with ethylene and other endogenous factors, such as sugar signaling. We finally review the growing knowledge related to abscisic acid, gibberellins, and the genus Citrus. We illustrate why this woody genus can be considered as an emerging model plant for understanding hormonal circuits in regulating different processes, as most of the finest work on this matter in recent years has been performed by using different Citrus species.In this article, a compact concentric structured monopole patch antenna for super wideband (SWB) application is proposed and investigated. The essential characteristics of the designed antenna are (i) to attain super-wide bandwidth characteristics, the proposed antenna is emerged from a traditional circular monopole antenna and has obtained an impedance bandwidth of 38.91 (ii) another important characteristic of the presented antenna is its larger bandwidth dimension ratio (BDR) value of 6596 that is accomplished by augmenting the electrical length of the patch. The electrical dimension of the proposed antenna is 0.18λ×0.16λ (λ corresponds to the lower end operating frequency). The designed antenna achieves a frequency range from 1.22 to 47.5 GHz with a fractional bandwidth of 190% and exhibiting S11 less then -10 dB in simulation. For validating the simulated outcomes, the antenna model is fabricated and measured. Good conformity is established between measured and simulated results. Measured frequency ranges from 1.25 to 40 GHz with a fractional bandwidth of 188%, BDR of 6523 and S11 less then -10 dB. Even though the presented antenna operates properly over the frequency range from 1.22 to 47.5 GHz, the results of the experiment are measured till 40 GHz because of the high-frequency constraint of the existing Vector Network Analyzer (VNA). The designed SWB antenna has the benefit of good gain, concise dimension, and wide bandwidth above the formerly reported antenna structures. Simulated gain varies from 0.5 to 10.3 dBi and measured gain varies from 0.2 to 9.7 dBi. Frequency domain, as well as time-domain characterization, has been realized to guide the relevance of the proposed antenna in SWB wireless applications. Furthermore, an equivalent circuit model of the proposed antenna is developed, and the response of the circuit is obtained. The presented antenna can be employed in L, S, C, X, Ka, K, Ku, and Q band wireless communication systems.

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