Healystern0642

Conclusion, our data suggest that alterations in uILC composition may disrupt the balance of immune microenvironment after T. gondii infection and contribute to the adverse pregnancy outcomes caused by T. gondii infection.By utilizing the complementary information from multiple views, multi-view clustering (MVC) algorithms typically achieve much better clustering performance than conventional single-view methods. Although in this field, great progresses have been made in past few years, most existing multi-view clustering methods still suffer the following shortcomings (1) most MVC methods are non-convex and thus are easily stuck into suboptimal local minima; (2) the effectiveness of these methods is sensitive to the existence of noises or outliers; and (3) the qualities of different features and views are usually ignored, which can also influence the clustering result. To address these issues, we propose dual self-paced multi-view clustering (DSMVC) in this paper. Specifically, DSMVC takes advantage of self-paced learning to tackle the non-convex issue. By applying a soft-weighting scheme of self-paced learning for instances, the negative impact caused by noises and outliers can be significantly reduced. Moreover, to alleviate the feature and view quality issues, we develop a novel feature selection approach in a self-paced manner and a weighting term for views. Telaprevir chemical structure Experimental results on real-world data sets demonstrate the effectiveness of the proposed method.This study examines which management methods are the most recent and advanced in managing rejected brine generated from desalination plants. It also provides up-to-date information regarding the most adequate technologies that generate a minimum quantity of rejected brine via the use of minimization techniques and analyzes the method of direct disposal that has lately received noticeable improvements. It further discusses the reuse of discarded brine to recover valuable goods and sequestration of carbon dioxide. Sustainability is an important parameter that needs consideration to achieve uninterrupted operation of the discarded brine management to achieve the least environmental, social, and economic aftermath. To properly deal with any environmental issues related to brine disposal, different methods are implemented so that, in the end, higher water recovery is achievable from the desalination processes, namely brine minimization and rejection technologies (pressure retarded osmosis, microbial desalination com the discharged concentrated brine waste. Certainly, attaining marketable products from the discharged concentrated brine would offer an economic benefit and reducing the whole desalination costs. Ion imprinting polymers have potential applications in metal recovery from brine. Finding selective, more efficient, and less expensive imprinted polymers for extraction/pre-concentration of valuable ions is a vital and challenging task. Lastly, the brine should be seen as a resource and not as a waste to attain sustainability in its management approaches. Hybrid processes would be highly recommended to get the absolute transformation of the discarded brine from desalination processes to more valuable constituents.Partially substituting chemical fertilizer with organic fertilizer has substantially changed the stoichiometric imbalances of carbon (C), nitrogen (N) and phosphorus (P) between microbial communities and their available resources in agroecosystems. However, how organic substitution alters microbial nutrient limitation and then affects soil N cycle in intensive greenhouse vegetable ecosystem, remain unknown. Thus, we performed a three-year greenhouse vegetable field experiment in China with different fertilization strategies no N fertilization, chemical N fertilization, and substituting 20% (1M4N) or 50% (1M1N) of chemical N with organic fertilizer (organic substitutions). Our results demonstrated that the microbial communities presented N limitation, accompanying with a strong NP but a weak CN (or P) microbial homeostasis in response to high NP imbalance among all treatments. Organic substitutions at 1M1N and 1M4N significantly aggravated microbial N limitation and decreased the gene abundances of nitrification and denitrification by 4.7%-27.3% than that of chemical N fertilization. Microbial N limitation was strongly influenced by NP stoichiometric imbalance illustrated from regression analysis. The N-cycling gene abundances were not only dependent on the inorganic N pool and soil physicochemical properties (i.e. pH and electrical conductivity), but also affected by microbial nutrient limitation inferred from random forest analysis. Furthermore, the 1M1N treatment performed better than the 1M4N in terms of improved crop yield and less microbial N limitation. Overall, these results highlight the importance of ecological stoichiometry in regulating soil N cycle under different fertilization strategies for intensive greenhouse vegetable ecosystem.Environmental Information Disclosure (EID) is a new tool for environmental governance in the era of big data and information. Based on the Pollution Information Disclosure Index (PITI) of 120 cities in China from 2003 to 2019, spatial data exploratory analysis and dynamic spatial panel model were adopted to analyze the spatial-temporal evolution characteristics and influencing factors of EID in China. The results show that (1) great progress of China's EID has been made in legislation and practice and its ways and channels are gradually becoming diversified, while it is accompanied by the problem of inadequate and unbalanced development; (2) EID shows the "superposition effect" promoted by previous accumulation has the "peer effect" of mutual imitation and learning and presents "demonstration effect", which shows significant agglomeration distribution pattern of spatial "club", while the spillover effect within the region is significant while the radiation effect between regions is weak. (3) In a dynamic process, cities with better economic development, firm performance, environmental performance and regulation, disclosure more environmental information, while the role of government competition and public participation needs further discussion. (4) Negative factors have a great influence during the economic crisis, while positive factors play a significant role in promoting the disclosure of environmental information during the economic expansion after crises. Cities in the developed regions (coastal, east and large cities) disclosure more than developing regions (inland, west, and small cities), and the positive factors are more likely to take effect.Forest ecosystem conservation practice frequently sacrifices human livelihood, since there exists a structural conflict between both aspects in the degraded forest ecosystem. To reconcile the conflict has been widely viewed as a core issue, in which the payment of ecosystem service (PES) may play a critical role in solving this issue. In order to better understand the practical effectiveness of PES and explore the solution to reconcile the contradiction between conservation and livelihood, we investigated the decadal changes in the Sloping Land Conversion Program as a PES strategy in the Qilian Mountains, a degraded forest ecosystem of northwest China, and its effects on natural and social systems across the 10-year implementation period (2001-2011). The regional NDVI of study site was promoted from 46.24% to 61.28%, showing that vegetation cover had a massive increase during the whole implementation period. Also, the PES strategy had impelled more labor forces as migrant workers into the non-agricultural industries or urban areas. The migration dynamics in three industries demonstrated that the population of primary industry followed a gradually declining trend, and its percentage in total population was lowered from 33.44% to 19.82%. According to our household survey, local farmers reduced the economic investment in agriculture, and this enabled more labor forces to be released from agricultural industry. Interestingly, the attitudes towards the PES program for local inhabitants were gradually shifted from negative at initial stage to acceptable at middle stage, and finally to positive at late stage, as a consequence of PES application. In such case, the PES-led vegetation restoration strategy has been effectively implemented, which can reconcile the contradiction between conservation and livelihood, and ultimately achieve a win-win consequence. Our study provided a successful practical paradigm of coupled human and natural system (CHANS) in forest ecosystem restoration.

The high rate of comorbidity between alcohol use and emotional disorders is well demonstrated, but the mechanisms underlying their relationship remain largely unidentified. One possibility is maladaptive responding to negative affect, such as worry and rumination. The present study sought to examine worry and rumination as putative mediators explaining the link between emotional disorders and alcohol use disorders. Methods Mediational analyses were conducted using a sample (n=232) derived from a larger late adolescence/early adulthood longitudinal dataset (Youth Emotion Project; Zinbarg et al., 2010). Results A significant indirect effect was observed for emotional disorder severity on alcohol use disorder severity via rumination, but not via worry or the shared variance between worry and rumination. Conclusions These findings suggest that rumination may specifically confer risk for the development of alcohol use disorder for individuals with emotional disorders. Further, ruminative thinking may serve as a uals with emotional disorders. Further, ruminative thinking may serve as a specific treatment target to reduce vulnerability to alcohol use disorder.

Prostate specific membrane antigen (PSMA) is a type II membrane protein widely expressed on the surface of prostate cancer cells. One of its functions is to act as a receptor mediating the ligand internalization. This PSMA property is employed in the diagnostics and therapy of prostate cancer. Over the years, small molecules with high affinity for PSMA have been developed and labelled with positron emitters (e.g.

Ga,

F,

C,

Cu, or

Y). One of these radiolabelled ligands, [

Ga] PSMA-11, is one of the most widespread tracers for PET imaging of the prostate cancer. Many techniques have been proposed and tested for the

Ga labelling of PSMA-11. The aim of our work was to design a labelling method of PSMA-11 that minimizes number of the used chemicals and steps, providing quantitative labelling yield at laboratory temperature and may be easily automated.

A

Ge/

Ga generator eluate in 0.1M HCl was loaded on an activated Oasis MCX cartridge, and the cartridge was then thoroughly washed with water. Thed, developed and tested. The results demonstrated that it is rapid, simple, reproducible and easy to automate.

A new method of labelling PSMA-11 ligand with 68Ga in 0.1 M NaHCO3 using Oasis MCX cartridges was proposed, developed and tested. The results demonstrated that it is rapid, simple, reproducible and easy to automate.As a product of the shared economy, online car-hailing platforms can be used effectively to help maximize resources and alleviate traffic congestion. The driver's behavior is characterized by his or her driving style and plays an important role in traffic safety. This paper proposes a novel framework to classify driving styles (defined as aggressive, normal, and cautious) based on online car-hailing data to investigate the distinct characteristics of drivers when performing various driving tasks (defined as cruising, ride requests, and drop-off) and undergoing certain maneuvers (defined as turning, acceleration, and deceleration). The proposed model is constructed based on the detection and classification of driving maneuvers using a threshold-based endpoint detection approach, principal component analysis, and k-means clustering. The driving styles that the driver exhibits for the different driving tasks are compared and analyzed based on the classified maneuvers. The empirical results for Nanjing, China demonstrate that the proposed framework can detect driving maneuvers and classify driving styles accurately.